FATarget SIGNED
Drugs targets in sympathetic neurons controlling adiposity.
Total Cost €
0EC-Contrib. €
0Partnership
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0FATarget project word cloud
Explore the words cloud of the FATarget project. It provides you a very rough idea of what is the project "FATarget" about.
Project "FATarget" data sheet
The following table provides information about the project.
| Coordinator |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 183˙454 € |
| EC max contribution | 183˙454 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2017 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-06-03 to 2021-06-02 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | coordinator | 183˙454.00 |
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Project objective
Obesity is a metabolic disorder with unmet medical need for which a pharmacotherapy is urgently needed. The Domingos lab has recently discovered that sympathetic (SNS) neuro-adipose junctions mediate lipolysis and fat mass reduction (Pirzgalska, R.M., Cell, 2015).Thus direct and targeted activation of sympathetic inputs to adipose tissues could represent a new strategy for the induction of fat loss. Our main objective is to identify drug targets in SNS neurons innervating fat, which are suitable for an anti-obesity therapy. To achieve this, we will use technologies such as Translational Ribosome Affinity Purification (TRAP) for translational profiling of neurons innervating fat. We will differentially screen for molecular targets that are enriched in SNS neurons in fat. We will validate target expression in human SNS tissues. This project will identify neuro-excitatory drug targets in sympathetic inputs to adipose tissues, and may lead the development of pharmacotherapies which would circumvent side effects.
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The information about "FATARGET" are provided by the European Opendata Portal: CORDIS opendata.