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PULVAD TERMINATED

Pressure Unloading LVAD: An Explantable and Cost-Effective Bridge to Recovery in Heart Failure

Total Cost €

EC-Contrib. €

Partnership

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PULVAD project word cloud

Explore the words cloud of the PULVAD project. It provides you a very rough idea of what is the project "PULVAD" about.

socioeconomic burden life exploited paired lvads recover cardiac animal randomized designed failing assist validated biopsies acute ease histological model lvad feasibility cellular human engineered mechanoenergetics perform first unloading hemodynamics safety mechanical remodeling myocardial bridge molecular ventricular mechanisms reverse efficacy translational investigation systemic left quality recovery sustained fill pulvad innovative void post heart chronic insufficiently underlying pressure pivotal

Project "PULVAD" data sheet

The following table provides information about the project.

Coordinator	ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Organization address address: 6 CHRISTOU LADA STR city: ATHINA postcode: 10561 website: www.elke.uoa.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Total cost	164˙653 €
EC max contribution	164˙653 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-10-31 to 2017-10-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Organization address address: 6 CHRISTOU LADA STR city: ATHINA postcode: 10561 website: www.elke.uoa.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	coordinator	164˙653.00

Map

Project objective

The ability of the failing human heart to recover after mechanical unloading with left ventricular assist devices (LVADs) has been insufficiently exploited. To fill this void, we engineered the Pressure Unloading LVAD (PULVAD) system, designed to promote myocardial recovery. The overall objective of the proposed translational investigation is to evaluate the feasibility, safety and efficacy of this innovative pressure unloading approach as a bridge to recovery from heart failure. We will first investigate the effects of short-term PULVAD support on systemic hemodynamics and left ventricular mechanoenergetics in a large animal model of acute heart failure. We will then perform a pivotal randomized controlled study to investigate the safety and efficacy of long-term PULVAD support in promoting sustained cardiac recovery in a large animal model of chronic heart failure. If validated, this new technology has the potential to improve quality of life and ease the socioeconomic burden of advanced heart failure. In addition, histological, cellular and molecular analysis of paired myocardial biopsies obtained pre/post-PULVAD unloading will provide insight into mechanisms underlying cardiac reverse remodeling and myocardial recovery.

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The information about "PULVAD" are provided by the European Opendata Portal: CORDIS opendata.