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HYPOXFLU

[18F]Fluorination of alkylCF3 and alkylCF2CF3 chains-Application to hypoxia biomarkers for PET imaging.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

HYPOXFLU project word cloud

Explore the words cloud of the HYPOXFLU project. It provides you a very rough idea of what is the project "HYPOXFLU" about.

species perform ef5 fluoride biomarker boronic automated trifluoromethylated synthesis hypoxia alkyl clinical radiolabelled fluorination direct fmiso 18f solution protocol cf2 copper cf3 radiochemistry counterparts biomarkers chains labelling imaging pet ef3 mediated challenged first perfluorinated

Project "HYPOXFLU" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://users.ox.ac.uk/
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-03-16 to 2017-03-15

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	coordinator	195˙454.00

Map

Project objective

The first objective of this proposal is to provide a solution to a well recognized problem in 18F-radiochemistry: the direct [18F]fluorination of trifluoromethylated and perfluorinated (CF2-CF3) alkyl chains. We propose to investigate a copper-mediated fluorination of alkyl boronic species using [18F]fluoride. The value of this new radiochemistry will be challenged with the synthesis and the labelling of two well-known and promising biomarkers for hypoxia, EF3 and EF5. We propose to develop an automated protocol for the production of their radiolabelled counterparts, and to perform a pre-clinical comparative study of [18F]EF3 and [18F]EF5 with [18F]FMISO, the current hypoxia biomarker used for PET imaging.

Publications

List of publications.
year	authors and title	journal	last update
2015	Miriam Oâ€™Duill, Emmanuelle Dubost, Lukas Pfeifer, and Veronique Gouverneur Cross-Coupling of [2-Aryl-1,1,2,2-tetrafluoroethyl](trimethyl)silaneswith Aryl Halides published pages: , ISSN: 1523-7060, DOI: 10.1021/acs.orglett.5b01510	Organic letters	2019-07-24

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The information about "HYPOXFLU" are provided by the European Opendata Portal: CORDIS opendata.