Explore the words cloud of the NOVEL project. It provides you a very rough idea of what is the project "NOVEL" about.
The following table provides information about the project.
Coordinator |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Organization address contact info |
Coordinator Country | France [FR] |
Project website | http://vincentcastric.weebly.com |
Total cost | 1˙760˙880 € |
EC max contribution | 1˙760˙880 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2014-CoG |
Funding Scheme | ERC-COG |
Starting year | 2015 |
Duration (year-month-day) | from 2015-10-01 to 2020-09-30 |
Take a look of project's partnership.
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1 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | coordinator | 1˙760˙880.00 |
The emerging field of systems biology is revealing the intricate nature of biological organisms, whereby a large fraction of their individual components (genes, proteins, regulatory elements) interact with several others. The co-evolutionary processes that this entails raises the question of how phenotypic novelty may arise in the course of evolution, since all parts of the system have to evolve in a coordinated manner if the phenotype is to remain functional. For most biological systems, however, we are lacking even basic insight into the fine-scale mechanistic constraints and the underlying ecological context. In this project, we will focus on the sporophytic self-incompatibility system in outcrossing Arabidopsis species, a model biological system in which two distinct co-evolutionary processes are becoming well-understood: 1) between the male and female reproductive proteins allowing self-pollen recognition and rejection and 2) between small non-coding RNAs and their target sites that jointly control the dominance/recessivity interactions between self-incompatibility alleles. By studying these two model systems, we will aim to catch the emergence of functional and regulatory novelty in flagrante delicto. We will take a multidisciplinary approach combining theoretical and empirical population genetics, evolutionary genomics and ancestral protein resurrection using transgenic plants. Our goal is threefold: 1) decrypt the molecular alphabet of the interaction between co-evolving nucleotide sequences, 2) predict and evaluate the fitness landscapes upon which the two co-evolutionary processes are taking place and 3) exploit natural variation in closely related species to unveil the kind of co-evolutionary process in natural populations. Our combination of various powerful approaches in a tractable model system should provide insight on diversification, a poorly understood but fundamental evolutionary process that is taking place at all levels of organization.
year | authors and title | journal | last update |
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2017 |
Pierre Saumitou-Laprade, Philippe Vernet, Xavier Vekemans, Vincent Castric, Gianni Barcaccia, Bouchaïb Khadari, Luciana Baldoni Controlling for genetic identity of varieties, pollen contamination and stigma receptivity is essential to characterize the self-incompatibility system of Olea europaea L. published pages: 860-866, ISSN: 1752-4571, DOI: 10.1111/eva.12498 |
Evolutionary Applications 10/9 | 2020-04-23 |
2017 |
Sier-Ching Chantha, Adam C. Herman, Vincent Castric, Xavier Vekemans, William Marande, Daniel J. Schoen The unusual S locus of Leavenworthia is composed of two sets of paralogous loci published pages: 1247-1255, ISSN: 0028-646X, DOI: 10.1111/nph.14764 |
New Phytologist 216/4 | 2020-04-23 |
2017 |
Takashi Tsuchimatsu, Pauline M. Goubet, Sophie Gallina, Anne-Catherine Holl, Isabelle Fobis-Loisy, Hélène Bergès, William Marande, Elisa Prat, Dazhe Meng, Quan Long, Alexander Platzer, Magnus Nordborg, Xavier Vekemans, Vincent Castric Patterns of Polymorphism at the Self-Incompatibility Locus in 1,083 Arabidopsis thaliana Genomes published pages: , ISSN: 0737-4038, DOI: 10.1093/molbev/msx122 |
Molecular Biology and Evolution | 2020-04-23 |
2017 |
Polina Yu. Novikova, Takashi Tsuchimatsu, Samson Simon, Viktoria Nizhynska, Viktor Voronin, Robin Burns, Olga M. Fedorenko, Svante Holm, Torbjörn Säll, Elisa Prat, William Marande, Vincent Castric, Magnus Nordborg Genome sequencing reveals the origin of the allotetraploid Arabidopsis suecica published pages: msw299, ISSN: 0737-4038, DOI: 10.1093/molbev/msw299 |
Molecular Biology and Evolution | 2020-04-23 |
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