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ChiralCatLnCoils SIGNED

De novo design of Lanthanide coiled coils for asymmetric catalysis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
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ChiralCatLnCoils project word cloud

Explore the words cloud of the ChiralCatLnCoils project. It provides you a very rough idea of what is the project "ChiralCatLnCoils" about.

advantages chemistry de realise peptide lccs complexes interface training scratch coupled dr combination kinetics edge anbu lcc coiled ligands supervisor herein first hard unlocking lanthanide biology strategy conjunction catalytic metalloenzymes rapid protein class peacock chirality ligand designed time bioinorganic lewis acidity inorganic water previously unexplored fold chiral catalysis ing full residues science combining complementary secondments perform metallopeptide coils attractive exchange cutting exquisite lnn sphere novo expertise

Project "ChiralCatLnCoils" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.birmingham.ac.uk/staff/profiles/chemistry/peacock-anna.aspx
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2017-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	coordinator	195˙454.00

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Project objective

Herein, we propose to design de novo (“from scratch”), a new class of lanthanide coiled coils (LCC) for chiral catalysis in water. The attractive features of Lnn complexes (strong and hard Lewis acidity, high coordination numbers and rapid ligand-exchange kinetics), will for the first time be coupled with de novo designed coiled coils, which offer the advantages of the protein ligand in metalloenzymes, for applications in catalysis.The resulting novel LCCs will exploit the peptide fold, chirality and second sphere residues, in order to perform exquisite chiral catalysis in water. This programme of work will provide a new strategy for unlocking the full potential of science at the interface of biology and inorganic chemistry, by combining previously unexplored ligands with traditional inorganic complexes, for applications beyond those offered by biology. The complementary expertise of Dr Anbu (bioinorganic catalysis) and the supervisor Dr Peacock (metallopeptide design) offer the unique combination to realise the full catalytic potential of LCCs, and will, in conjunction with two planned short secondments, provide Dr Anbu with new and cutting-edge research training.

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The information about "CHIRALCATLNCOILS" are provided by the European Opendata Portal: CORDIS opendata.