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AFIBROTIC

Atrial Fibrillation, Fibrosis and Rotors: New Insights from Imaging and Computational Modeling

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 AFIBROTIC project word cloud

Explore the words cloud of the AFIBROTIC project. It provides you a very rough idea of what is the project "AFIBROTIC" about.

experimental    vivo    relationship    silico    operator    electrophysiology    environment    atrium    data    network    measured    expertise    fibrillation    fibrosis    medical    patient    lack    interventional    modeling    initiate    enlarged    instrumentation    implied    af    transfer    fibrillating    catheter    debated    ablation    incompletely    mechanistic    nonetheless    personalized    procedure    rates    dependent    responsiveness    connecting    synergy    acquired    explaining    connection    showing    treatment    planning    substantial    engineering    first    benefit    rotors    correlates    model    solid    fundaments    principally    deprives    sustain    atrial    grant    mechanisms    career    computational    biomedical    complementary    amount    reentries    rigorous    outcomes    electrical    mortality    causes    maintained    promise    framework    morbidity    host    clinical    imaging    improves    tool    patients    suppression    unfortunately    basis    pathophysiology    arrhythmia   

Project "AFIBROTIC" data sheet

The following table provides information about the project.

Coordinator
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA 

Organization address
address: VIA ZAMBONI 33
city: BOLOGNA
postcode: 40126
website: www.unibo.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.biomig.dei.unibo.it/FA.html
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) coordinator 168˙277.00

Map

 Project objective

Atrial fibrillation (AF) is the most common type of arrhythmia and causes substantial morbidity and mortality. AF is principally treated with catheter ablation. Unfortunately, the mechanisms that initiate and sustain the arrhythmia are still incompletely understood and, as such, ablation remains a highly operator-dependent procedure with low success rates. Two recent studies promise to lead to better ablation outcomes, showing that a) the amount of atrial fibrosis directly correlates with the non-responsiveness to ablation and that b) AF is maintained by electrical rotors and targeting their suppression improves the success rates. Nonetheless, the lack of a rigorous mechanistic framework of AF pathophysiology deprives those studies of solid fundaments so that their effective value is still debated.

This project aims therefore to provide such a framework by exploiting advanced biomedical engineering concepts. The focus will be on explaining and connecting recent experimental findings about fibrosis and rotors. The relationship will be first analyzed in vivo from AF patient data acquired with state-of-the-art instrumentation in the field of interventional electrophysiology. Measured data will be then integrated within a multi-scale personalized computational model of the fibrillating atrium that will determine, on a patient-specific basis, the mechanistic connection between fibrosis and reentries. Furthermore, the tool will provide an in silico environment for personalized ablation planning. Key in the project will be the synergy between complementary state-of-the-art expertise in the fields of medical imaging and computational modeling provided by applicant and host institutions. All partners will strongly benefit from the implied two way knowledge transfer, in terms of career advancement (the applicant) and enlarged network/grant proposal opportunities. The study will foster more focused clinical research aiming at better treatment for the AF patients.

 Publications

year authors and title journal last update
List of publications.
2017 Maddalena Valinoti, Francesca Berto, Martino Alessandrini, Roberto Mantovan, Axel Loewe, Olaf Doessel, Stefano Severi, Cristiana Corsi
Phase Analysis of Endoatrial Electrograms for 3D Rotor Detection in Atrial Fibrillation,
published pages: , ISSN: , DOI:
Computing in Cardiology, Rennes, FR 2019-06-17
2017 Masci A, Martino Alessandrini, Davide Forti, Filippo Menghini, Luca Dedé, Corrado Tommasi, Alfio Quarteroni, and Cristiana Corsi
A Patient-Specific Computational FluidDynamics Model of the Left Atrium in AtrialFibrillation: Development and Initial Evaluation
published pages: , ISSN: , DOI:
Proc. of Functional Imaging and Modeling of the Heart (FIMH), Toronto, CA 2019-06-17
2018 Claudio Fabbri, Maddalena Valinoti, Cristiana Corsi, Martino Alessandrini
Segmentation of cardiac structures
published pages: , ISSN: , DOI:
Cardiovascular Computing: Methodologies and Clinical Applications. Editors: Spyretta Golemati and Konstantina S. Nikita 2019-06-17
2017 Carolina Vallecilla, Martino Alessandrini, Claudio Fabbri, Corrado Tomasi, Cristiana Corsi, Stefano Severi
Preliminary Computational Framework to Map MRI Derived Markers to Predict Response to Cardiac Resynchronization Therapy
published pages: , ISSN: , DOI:
Computing in Cardiology 2017, Rennes, FR 2019-06-17
2017 Martino Alessandrini, Maddalena Valinoti, Axel Loewe, Tobias Oesterlein, Olaf Doessel, Cristiana Corsi, Stefano Severi
A Computational Framework to Benchmark Basket Catheter Guided Ablation (IN PRESS)
published pages: , ISSN: , DOI:
Computing in Cardiology 2017, Rennes, FR 2019-06-17
2016 M. Alessandrini, M. Valinoti, A. Pasini, R. Mantovan, S. Severi and C. Corsi
An automatic framework for the non-rigid alignment of electroanatomical maps and preoperative anatomical scans in atrial fibrillation
published pages: , ISSN: , DOI:
Proc. of Computing in Cardiology 2016, Vancouver, CA 2019-06-17
2018 M. Alessandrini
Combined techniques of filtering and speckle tracking
published pages: , ISSN: , DOI:
Handbook of Speckle Filtering and Tracking in Cardiovascular Ultrasound Imaging and Video. Editors: Christos Loizou, Constantinos Pattichis and Jan D’hooge 2019-06-17
2018 Martino Alessandrini, B. Chakraborty, B. Heyde, O. Bernard, M. De Craene, M Sermesant, J. D’hooge
Realistic Vendor Specific Sythetic Ultrasound Data for Quality Assurance of 2D Speckle Tracking Echocardiography: Simulation pipeline and Open Access Database. ACCEPTED FOR PUBLICATION.
published pages: , ISSN: 0885-3010, DOI:
IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 2019-06-17
2017 Alessandro Masci, Martino Alessandrini, Luca Dedè, Davide, Forti, Filippo Menghini, Corrado Tomasi, Alfio Quarteroni, Cristiana Corsi
Development of a Computational Fluid Dynamics Model of the Left Atrium in Atrial Fibrillation on a Patient Specific Basis
published pages: , ISSN: , DOI:
Computing in Cardiology 2017, Rennes, FR 2019-06-17

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