#	Pagina
attuale pagina	/open-h2020/projects/195723/index.html

Opendata, web and dolomites

AND

Antibacterial (Nano)medicines Development

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

AND project word cloud

Explore the words cloud of the AND project. It provides you a very rough idea of what is the project "AND" about.

discovery catalytic kinase resistance intrinsic hk strains atp inexorable histidine mutant biding mutations putative euros transposon spectrum domain medicines individual despite drug ca antibiotics billions bacterial mechanism insertion inhibitors investment libraries tn decline last strategy mdr decades nano sensitivity fellowship antibacterial broad resistant

Project "AND" data sheet

The following table provides information about the project.

Coordinator	WAGENINGEN UNIVERSITY Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB website: http://www.wageningenur.nl/nl.htm contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.wur.nl/en/project/Antibacterial-Nanomedicines-Development.htm
Total cost	165˙598 €
EC max contribution	165˙598 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-04-01 to 2017-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	WAGENINGEN UNIVERSITY WAGENINGEN UNIVERSITY Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB website: http://www.wageningenur.nl/nl.htm contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (WAGENINGEN)	coordinator	165˙598.00

Map

Project objective

Despite the investment of billions of euros, there has been an inexorable decline in the discovery of new antibiotics over the last decades. In this individual fellowship (IF) application we propose a strategy to develop bacterial histidine-kinase (HK) inhibitors targeted at the catalytic and ATP-biding domain (CA) as novel broad-spectrum antibacterial (nano)medicines. Furthermore, putative mechanism of resistance to HK inhibitors and known antibiotics will be studied and novel antibacterial drug targets will be identified by using transposon insertion mutant libraries (Tn-libraries) to identify mutations involved in intrinsic resistance to antibiotics and/or leading to increased sensitivity to existing antibiotics in multi-drug resistant (MDR) strains.

Publications

List of publications.
year	authors and title	journal	last update
2016	Nadya Velikova, Kevin Kavanagh, Jerry M. Wells Evaluation of Galleria mellonella larvae for studying the virulence of Streptococcus suis published pages: , ISSN: 1471-2180, DOI: 10.1186/s12866-016-0905-2	BMC Microbiology 16/1	2019-07-24
2016	Nadya Velikova, Nuria Mas, Laura Miguel-Romero, Lorena Polo Aguado, Ellen Stolte, Edoardo Zaccaria, Rui Cao, Nico Taverne, JosÃ© RamÃ³n MurguÃa, Ramon Martinez-Manez, Alberto Marina, Jerry Wells Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of Îµ-poly-L-lysine capped mesoporous silica-based nanoparticles published pages: , ISSN: 1549-9634, DOI: 10.1016/j.nano.2016.09.011	Nanomedicine: Nanotechnology, Biology and Medicine	2019-07-24

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "AND" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "AND" are provided by the European Opendata Portal: CORDIS opendata.