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FourFeFourS

Molecular Understanding of Generation and Trafficking of Mitochondrial [4Fe-4S] Clusters

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 FourFeFourS project word cloud

Explore the words cloud of the FourFeFourS project. It provides you a very rough idea of what is the project "FourFeFourS" about.

fe    union    nuclear    manner    tutelage    microorganisms    unified    proteins    stability    biogenesis    4fe    roles    concentrations    science    foundation    expertise    leader    ions    sense    utmost    depends    isolated    spectrometric    expand    qua    basic    function    discover    structure    disease    responsible    conjunction    efforts    biochemistry    mechanisms    fatal    maintenance    sine    dictates    inorganic    biological    expert    reconstitution    2fe    dysfunction    incorporating    genomic    isc    fine    vital    mitochondrial    play    fourfefours    shed    entails    combine    assay    group    experiments    maturation    elucidate    active    metal    machinery    protein    molecular    underlying    energy    cytosolic    assembly    light    solid    human    world    dna    clusters    elucidation    biotechnological    cluster    17    career    relevance    multidisciplinary    chemicals    iron    poorly    transfer    biology    edge    ongoing    biochemical    intends    sulfur    broadest    diseases    mitochondria    cutting    least    spectroscopic    integrity    functions    utilizing    2s    outside    cellular    4s   

Project "FourFeFourS" data sheet

The following table provides information about the project.

Coordinator		 PHILIPPS UNIVERSITAET MARBURG 

Organization address
address: BIEGENSTRASSE 10
city: MARBURG
postcode: 35037
website: www.uni-marburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website https://www.uni-marburg.de/fb20/cyto/lill/research
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-15   to  2017-06-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PHILIPPS UNIVERSITAET MARBURG DE (MARBURG) coordinator 159˙460.00

Map

 Project objective

Iron-sulfur [Fe-S] clusters play a vital role in numerous cellular functions. They are a sine qua non for cellular energy production and maintenance of genomic stability. Therefore, elucidation of the biogenesis of [2Fe-2S] and [4Fe-4S] proteins is of utmost importance for basic science in its broadest sense, as it is for ongoing efforts to establish their relevance to human disease and their utilization for biotechnological production of fine chemicals in microorganisms. The iron-sulfur cluster (ISC) assembly process is responsible for incorporating the inorganic cluster into [Fe-S]-associated proteins in the mitochondria. Cytosolic and nuclear [Fe-S] protein assembly that dictates cellular iron concentrations and DNA integrity outside of the mitochondria also depends on the function of the ISC machinery. The mitochondrial ISC biogenesis machinery entails at least 17 proteins, yet how the proteins for [4Fe-4S] maturation work in a unified manner to produce the active cluster and transfer it to target proteins remains poorly understood. FourFeFourS intends to discover the underlying mechanisms of [4Fe-4S] biogenesis in the mitochondria, which could shed new light into how dysfunction of the proteins involved may lead to fatal diseases. To this end, studies will combine a biochemical reconstitution assay of the biological process utilizing isolated ISC proteins in conjunction with spectroscopic and spectrometric experiments that elucidate detailed protein function and molecular structure. In carrying out this cutting-edge research under the tutelage of a world-leading expert on iron-sulfur protein biogenesis, I will expand my expertise within the multidisciplinary field of biochemistry – in particular my understanding of the roles of metal ions in biology. In the process, I will build a solid foundation for a future research career as a group leader within the European Union.

 Publications

year authors and title journal last update
List of publications.
2017 Joseph J. Braymer, Roland Lill
Iron–sulfur cluster biogenesis and trafficking in mitochondria
published pages: 12754-12763, ISSN: 0021-9258, DOI: 10.1074/jbc.R117.787101 		Journal of Biological Chemistry 292/31 2019-07-24

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