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nAChR PAM-to-gate

Gating mechanism and pharmacological modulation of nicotinic acetylcholine receptors

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

nAChR PAM-to-gate project word cloud

Explore the words cloud of the nAChR PAM-to-gate project. It provides you a very rough idea of what is the project "nAChR PAM-to-gate" about.

treatment holds schizophrenia anaesthetics nicotine plgics paving bilayer plasmon disease electrophysiology membrane positive channels surface receptors insights anxiolytics gated purify specialized allosteric cell alcohols lines molecular planar communication neurotransmitter mechanisms regulation determinants proteins modulators promises ligand resonance pentameric binding ion deciphering glycine nicotinic gabaa pathologies neuronal acetylcholine lipid therapeutic pharmacological alzheimer neurons rational pharmacology addiction express 5ht3

Project "nAChR PAM-to-gate" data sheet

The following table provides information about the project.

Coordinator	INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	https://research.pasteur.fr/en/team/channel-receptors/
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-CAR
Starting year	2015
Duration (year-month-day)	from 2015-04-01 to 2017-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	coordinator	185˙076.00

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Project objective

Pentameric ligand-gated ion channels (pLGICs), including nicotinic acetylcholine, 5HT3, glycine, and GABAA receptors, are membrane proteins specialized in the communication between neurons. These neurotransmitter receptors are the target of general anaesthetics, anxiolytics, alcohols and nicotine. In particular, enhancing the activity of neuronal nicotinic receptors holds promises in the treatment of pathologies including nicotine addiction, schizophrenia and Alzheimer’s disease. The current project aims at deciphering the molecular and pharmacological determinants of positive allosteric modulators of neuronal nicotinic receptors. We will over-express and purify these proteins, study their pharmacology through electrophysiology in cell lines and planar lipid bilayer, and surface plasmon resonance binding studies. Our study will provide insights into the molecular mechanisms of allosteric regulation, paving the way for the rational design of allosteric modulators with therapeutic potential.

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