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depreg

Antidepressants during pregnancy: underlying mechanisms associated with neurodevelopmental outcome

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

depreg project word cloud

Explore the words cloud of the depreg project. It provides you a very rough idea of what is the project "depreg" about.

exposed risk humans unfortunately unclear tremendous therapeutic treatment genes patients avenues found alterations antidepressant rat plasma antidepressants model expression pregnancy mechanisms difficult reveal yielded adult itself point symptoms drug child patterns behavior antenatal negatively outcome biomarkers depressive underlying fetal pregnant profile experimental altered pharmacological human treatments ultimately solutions association beneficial micro health genome combination depression discern utero epigenetic biomedical offspring molecular depressed blood gene brain array frequently children behavioral

Project "depreg" data sheet

The following table provides information about the project.

Coordinator	RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.rug.nl/staff/j.d.a.olivier/projects
Total cost	177˙598 €
EC max contribution	177˙598 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2017-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	coordinator	177˙598.00

Map

Project objective

Depressive symptoms frequently occur during pregnancy and may have a tremendous impact on the developing child. Unfortunately, pharmacological antidepressant treatments during pregnancy can negatively impact behavioral development and health of the offspring. In humans it is difficult to discern between the effects of the drug and the effects of the depression itself, therefore it is unclear whether children exposed to antidepressants in utero are at increased risk, and if so, what the underlying molecular mechanisms are that may point to potential solutions.

My overall aim is to identify molecular mechanisms and behavioral alterations in the offspring due to antenatal depression, antidepressant treatment during pregnancy, and their combination. To achieve this goal I will use an advanced rat model for depression to allow an experimental approach. I will identify the effects of antenatal depression, antidepressant treatment during pregnancy, and their combination on: (1) behavior of the offspring, (2) gene expression patterns with micro-array in the fetal brain, and (3) epigenetic profile of genes from the micro-array in adult brain and blood plasma.

So far, Genome Wide Association Studies have not yielded new targets for the treatment of depressed (pregnant) patients. The outcome of this study will not only advance our knowledge on genes underlying the alterations found in brain and blood of the offspring due to antenatal depression, antidepressant treatment and their combination, but will also reveal early biomarkers as the epigenetic profile for the altered genes are studied. Ultimately, the results of this project will be beneficial for human health as it will open up new avenues for biomedical research and therapeutic applications.

Publications

List of publications.
year	authors and title	journal	last update
2017	Danielle J. Houwing, Bauke Buwalda, Eddy A. van der Zee, Sietse F. de Boer, Jocelien D. A. Olivier The Serotonin Transporter and Early Life Stress: Translational Perspectives published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2017.00117	Frontiers in Cellular Neuroscience 11	2019-07-24
2017	Sahar El Aidy, Anouschka S. Ramsteijn, Francisco Dini-Andreote, Roel van Eijk, Danielle J. Houwing, Joana F. Salles, Jocelien D. A. Olivier Serotonin Transporter Genotype Modulates the Gut Microbiota Composition in Young Rats, an Effect Augmented by Early Life Stress published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2017.00222	Frontiers in Cellular Neuroscience 11	2019-07-24

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The information about "DEPREG" are provided by the European Opendata Portal: CORDIS opendata.