Explore the words cloud of the depreg project. It provides you a very rough idea of what is the project "depreg" about.
The following table provides information about the project.
Coordinator |
RIJKSUNIVERSITEIT GRONINGEN
Organization address contact info |
Coordinator Country | Netherlands [NL] |
Project website | http://www.rug.nl/staff/j.d.a.olivier/projects |
Total cost | 177˙598 € |
EC max contribution | 177˙598 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2014 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2015 |
Duration (year-month-day) | from 2015-06-01 to 2017-05-31 |
Take a look of project's partnership.
# | ||||
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1 | RIJKSUNIVERSITEIT GRONINGEN | NL (GRONINGEN) | coordinator | 177˙598.00 |
Depressive symptoms frequently occur during pregnancy and may have a tremendous impact on the developing child. Unfortunately, pharmacological antidepressant treatments during pregnancy can negatively impact behavioral development and health of the offspring. In humans it is difficult to discern between the effects of the drug and the effects of the depression itself, therefore it is unclear whether children exposed to antidepressants in utero are at increased risk, and if so, what the underlying molecular mechanisms are that may point to potential solutions.
My overall aim is to identify molecular mechanisms and behavioral alterations in the offspring due to antenatal depression, antidepressant treatment during pregnancy, and their combination. To achieve this goal I will use an advanced rat model for depression to allow an experimental approach. I will identify the effects of antenatal depression, antidepressant treatment during pregnancy, and their combination on: (1) behavior of the offspring, (2) gene expression patterns with micro-array in the fetal brain, and (3) epigenetic profile of genes from the micro-array in adult brain and blood plasma.
So far, Genome Wide Association Studies have not yielded new targets for the treatment of depressed (pregnant) patients. The outcome of this study will not only advance our knowledge on genes underlying the alterations found in brain and blood of the offspring due to antenatal depression, antidepressant treatment and their combination, but will also reveal early biomarkers as the epigenetic profile for the altered genes are studied. Ultimately, the results of this project will be beneficial for human health as it will open up new avenues for biomedical research and therapeutic applications.
year | authors and title | journal | last update |
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2017 |
Danielle J. Houwing, Bauke Buwalda, Eddy A. van der Zee, Sietse F. de Boer, Jocelien D. A. Olivier The Serotonin Transporter and Early Life Stress: Translational Perspectives published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2017.00117 |
Frontiers in Cellular Neuroscience 11 | 2019-07-24 |
2017 |
Sahar El Aidy, Anouschka S. Ramsteijn, Francisco Dini-Andreote, Roel van Eijk, Danielle J. Houwing, Joana F. Salles, Jocelien D. A. Olivier Serotonin Transporter Genotype Modulates the Gut Microbiota Composition in Young Rats, an Effect Augmented by Early Life Stress published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2017.00222 |
Frontiers in Cellular Neuroscience 11 | 2019-07-24 |
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The information about "DEPREG" are provided by the European Opendata Portal: CORDIS opendata.