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ParaplegiaERDros

Roles of spastic paraplegia proteins in organisation of axonal endoplasmic reticulum

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ParaplegiaERDros project word cloud

Explore the words cloud of the ParaplegiaERDros project. It provides you a very rough idea of what is the project "ParaplegiaERDros" about.

adults multiply forms localized mutant shape genotypes disease mutations poorly cell function mitochondria training paraplegia fellow mutated smooth disrupted finer characterisation larval environment time reticulum profile singly impaired she axon proteins protein opportune spastic detect encoding patients formed mainly human hsp disrupting organisation area axonal compartment association characterised live distances genes host network appear hereditary pioneer axons structure tools roles unknown lab drosophila tubular gene form motor model degeneration sensory endoplasmic age er defects

Project "ParaplegiaERDros" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.gen.cam.ac.uk/research-groups/okane
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2017-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	195˙454.00

Map

Project objective

Axonal endoplasmic reticulum (ER) is a poorly characterised compartment that is mainly tubular, smooth, and forms a network for long distances along axons. Many mutations for the motor axon degeneration disease, hereditary spastic paraplegia (HSP), affect proteins that model ER shape. The Fellow will test the model that these proteins help form axonal ER, which is disrupted when these proteins are mutated. The time for this is opportune; the host lab has developed tools to detect impaired axon ER organisation in Drosophila; and new HSP genes, some encoding ER proteins of unknown function, are being identified continuously in human patients. To identify proteins involved in its formation, the Fellow will test ER-localized HSP gene products, both singly and in multiply mutant genotypes, for roles in ER organisation in larval motor axons. She will also test whether similar defects appear in long motor and sensory axons in live adults as they age. Finally she will test the effects of HSP protein loss on the finer structure of ER and its association with mitochondria. Through this work the Fellow will help pioneer characterisation of a poorly understood but important cell compartment: how it is formed and some effects of disrupting it. Along with the broader research and training environment, this will help her to develop a profile for her own work in this area.

Publications

List of publications.
year	authors and title	journal	last update
2016	Belgin YalÃ§Ä±n, Lu Zhao, Martin Stofanko, Niamh C O\'Sullivan, Zi Han Kang, Annika Roost, Matthew R Thomas, Sophie Zaessinger, Olivier Blard, Alex L Patto, Valentina Baena, Mark Terasaki, Cahir J. O\'Kane Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins published pages: , ISSN: , DOI: 10.1101/069005	BioRxiv	2019-06-18
2017	YalÃ§Ä±n B, Zhao L, Stofanko M, O\'Sullivan NC, Kang ZH, Roost A, Thomas MR, Zaessinger S, Blard O, Patto AL, Sohail A, Baena V, Terasaki M, O\'Kane CJ \"Research data supporting \"\"Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins\"\"\" published pages: , ISSN: , DOI: 10.17863/CAM.12206	University of Cambridge Repository	2019-06-18
2017	Belgin YalÃ§Ä±n, Lu Zhao, Martin Stofanko, Niamh C O\'Sullivan, Zi Han Kang, Annika Roost, Matthew R Thomas, Sophie Zaessinger, Olivier Blard, Alex L Patto, Anood Sohail, Valentina Baena, Mark Terasaki, Cahir J O\'Kane Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.23882	eLife 6	2019-06-18

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