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ORGANO-GOLD CAT

Merging organo- and gold-catalysis to design cascade reactions: a shortcut toward molecular complexity

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 ORGANO-GOLD CAT project word cloud

Explore the words cloud of the ORGANO-GOLD CAT project. It provides you a very rough idea of what is the project "ORGANO-GOLD CAT" about.

generate    space    platform    broaden    reproducing    molecules    comprising    inspired    era    candidate    vast    carbocycles    starting    guiding    compounds    single    chemistry    compound    structures    discoveries    rate    furan    innovation    career    asymmetric    fused    screening    generation    underlying    position    changing    scaffolds    enantiopure    place    architecturally    discovery    chemical    molecule    collection    synthetic    chiral    conventional    structural    gold    strategies    biologically    conceptually    activation    organocatalysis    competencies    cultural    biological    move    ing    methodology    fractions    world    evolution    fellow    innovative    pursue    candidates    lundbeck    majority    consequently    heterocyclic    excellent    natural    hit    basic    play    catalytic    assembling    moieties    combine    catalysis    perception    yields    point    optimal    company    nature    possess    preparing    ideal    probability    pharma    powerful    libraries    pharmaceutical    diversity    drug    diverse   

Project "ORGANO-GOLD CAT" data sheet

The following table provides information about the project.

Coordinator		 FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Spain [ES]
 Project website http://www.iciq.org/research/research_group/prof-paolo-melchiorre/
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 158˙121.00

Map

 Project objective

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection comprising optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. The proposed research aims to develop conceptually innovative catalytic methods to rapidly generate, in one single step, architecturally complex chiral natural-like compounds. Natural products have been selected in evolution and their underlying structural scaffolds define biologically relevant fractions of chemical space. Consequently, compound libraries inspired by natural structures deliver lead candidates with a higher hit-rate than conventional lead generation strategies.

We will pursue the proposed research project under the guiding principle that compound development should be driven by discoveries and innovation in chemical methodology. The goal of the research project is to combine the potential of asymmetric organocatalysis and gold catalysis, powerful fields of molecule activation, to find cost-effective synthetic methods for reproducing the rich structural diversity of natural molecules. Since the vast majority of natural products and drug-like compounds possess heterocyclic moieties, we will focus on preparing diverse heterocyclic compounds, especially based on the furan unit. The resulting synthetic platform will be used as an ideal starting point for assembling enantiopure chiral 2,3-furan fused carbocycles, which, along with biological screening carried out in collaboration with a world-wide recognized pharma-company (Lundbeck A/S), will increase the probability of success in identifying drug-candidate structures. The multi-cultural nature of this project will greatly contribute to broaden the fellow competencies and will place him in an excellent position for the next career move

 Publications

year authors and title journal last update
List of publications.
2017 Mattia Silvi, Charlie Verrier, Yannick P. Rey, Luca Buzzetti, Paolo Melchiorre
Visible-light excitation of iminium ions enables the enantioselective catalytic ?-alkylation of enals
published pages: , ISSN: 1755-4330, DOI: 10.1038/nchem.2748 		Nature Chemistry Journal published monthly 2019-07-25

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