Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. organo-gold cat

ORGANO-GOLD CAT

Merging organo- and gold-catalysis to design cascade reactions: a shortcut toward molecular complexity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0
 Outcomes and results

 ORGANO-GOLD CAT project word cloud

Explore the words cloud of the ORGANO-GOLD CAT project. It provides you a very rough idea of what is the project "ORGANO-GOLD CAT" about.

move    broaden    play    chiral    fractions    natural    discovery    architecturally    nature    yields    methodology    catalytic    single    generate    fellow    perception    chemistry    fused    guiding    heterocyclic    drug    pharmaceutical    cultural    molecules    powerful    libraries    discoveries    molecule    competencies    pharma    screening    space    innovative    majority    preparing    reproducing    compounds    strategies    consequently    collection    hit    conventional    candidates    point    possess    combine    synthetic    gold    basic    career    structures    optimal    ing    biologically    place    carbocycles    position    pursue    diversity    lundbeck    rate    assembling    generation    evolution    chemical    inspired    organocatalysis    diverse    probability    scaffolds    platform    company    catalysis    asymmetric    conceptually    moieties    enantiopure    world    compound    starting    structural    comprising    candidate    activation    biological    furan    ideal    underlying    era    excellent    changing    vast    innovation   

Project "ORGANO-GOLD CAT" data sheet

The following table provides information about the project.

Coordinator		 FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Spain [ES]
 Project website http://www.iciq.org/research/research_group/prof-paolo-melchiorre/
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 158˙121.00

Map

 Project objective

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection comprising optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. The proposed research aims to develop conceptually innovative catalytic methods to rapidly generate, in one single step, architecturally complex chiral natural-like compounds. Natural products have been selected in evolution and their underlying structural scaffolds define biologically relevant fractions of chemical space. Consequently, compound libraries inspired by natural structures deliver lead candidates with a higher hit-rate than conventional lead generation strategies.

We will pursue the proposed research project under the guiding principle that compound development should be driven by discoveries and innovation in chemical methodology. The goal of the research project is to combine the potential of asymmetric organocatalysis and gold catalysis, powerful fields of molecule activation, to find cost-effective synthetic methods for reproducing the rich structural diversity of natural molecules. Since the vast majority of natural products and drug-like compounds possess heterocyclic moieties, we will focus on preparing diverse heterocyclic compounds, especially based on the furan unit. The resulting synthetic platform will be used as an ideal starting point for assembling enantiopure chiral 2,3-furan fused carbocycles, which, along with biological screening carried out in collaboration with a world-wide recognized pharma-company (Lundbeck A/S), will increase the probability of success in identifying drug-candidate structures. The multi-cultural nature of this project will greatly contribute to broaden the fellow competencies and will place him in an excellent position for the next career move

 Publications

year authors and title journal last update
List of publications.
2017 Mattia Silvi, Charlie Verrier, Yannick P. Rey, Luca Buzzetti, Paolo Melchiorre
Visible-light excitation of iminium ions enables the enantioselective catalytic ?-alkylation of enals
published pages: , ISSN: 1755-4330, DOI: 10.1038/nchem.2748 		Nature Chemistry Journal published monthly 2019-07-25

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ORGANO-GOLD CAT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ORGANO-GOLD CAT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ROSETTA (2020)

Deciphering the Role of aberrant glycOSylation in the rEsponse to Targeted TherApies for breast cancer

Read More  

POLINGO (2018)

The Politics of Legitimacy: Non-partisan global governance and networked INGO power in the global governance of post-war states

Read More  

CYBERSECURITY (2018)

Cyber Security Behaviours

Read More