#	Pagina
attuale pagina	/open-h2020/projects/227565/index.html

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PregnancyAD SIGNED

Antidepressant discontinuation during pregnancy and relapse risk in the perinatal period

Total Cost €

EC-Contrib. €

Partnership

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PregnancyAD project word cloud

Explore the words cloud of the PregnancyAD project. It provides you a very rough idea of what is the project "PregnancyAD" about.

risk perinatal ipsych fundamental innovative discontinuing antidepressant acquire populations urgently 50 leap disorders epidemiologist supervisors biostatistics pregnancy expertise genetics benefit coursework data time danish combining fetal retrieved form absent datasets skills profiling care demographics career conspicuously overarching pharmacological treatment population independent impacts estimates pregnant limited cohort international combinations period negative opportunity training clinical personal genomics fear fellow profound gaps mainstay psychiatric women sparse antidepressants genetic epidemiology anxiety ten adverse recommendations depressive personalized representative national first discontinuation planning relapse integrative multidisciplinary nature discontinue registers complicated

Project "PregnancyAD" data sheet

The following table provides information about the project.

Coordinator	AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Total cost	201˙392 €
EC max contribution	201˙392 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-GF
Starting year	2021
Duration (year-month-day)	from 2021-05-01 to 2023-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	coordinator	201˙392.00
2	THE UNIVERSITY OF QUEENSLAND THE UNIVERSITY OF QUEENSLAND Organization address address: ST LUCIA city: BRISBANE postcode: 4072 website: http://www.uq.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (BRISBANE)	partner	0.00

Map

Project objective

Antidepressants are the mainstay of pharmacological treatment for depressive and anxiety disorders in the perinatal period, and up to one in ten pregnant women take them. Among these women, over 50% discontinue antidepressants during pregnancy due to fear of possible adverse fetal effects. However, discontinuation may increase the risk of relapse, which can also have profound negative impacts. Evidence on perinatal relapse risk following antidepressant discontinuation during pregnancy is sparse and limited to highly selected populations. Moreover, the only factors considered in studies so far have been simple demographics and clinical features, while genetic profiling is conspicuously absent.

The project aims to address knowledge gaps which urgently need to be understood in order for clinical care to provide personalized antidepressant treatment recommendations around pregnancy. This overarching objective will identify women at low or high relapse risk after discontinuing antidepressants during pregnancy and determine risk factors of relapse to enable personal risk estimates for the first time, in a large representative population, combining demographics, clinical features and genetic data retrieved from Danish national registers and the Integrative Psychiatric Research (iPSYCH) cohort.

The project will provide a unique opportunity due to its multidisciplinary nature and innovative combinations of genetics and epidemiology. The proposed research will benefit from the expertise in genetics, genomics, and psychiatric epidemiology of the supervisors, and the fellow’s multidisciplinary skills in epidemiology and biostatistics applied on large, highly complicated datasets. The fellow will acquire state-of-the-art skills in the analysis of genetic data, planning, and management by training-through-research along with coursework. This project will form a fundamental leap towards her future independent career as a leading and international recognized epidemiologist.

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The information about "PREGNANCYAD" are provided by the European Opendata Portal: CORDIS opendata.