OptoVision SIGNED
Optogenetic investigation of cortical layer-6 neuron contributions to dynamic visual perception
Total Cost €
0EC-Contrib. €
0Partnership
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Project "OptoVision" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITY OF NEWCASTLE UPON TYNE
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | https://research.ncl.ac.uk/schmidlab/ |
| Total cost | 1˙405˙000 € |
| EC max contribution | 1˙405˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-12-01 to 2020-11-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITY OF NEWCASTLE UPON TYNE | UK (NEWCASTLE UPON TYNE) | coordinator | 1˙405˙000.00 |
Map
Project objective
In order to achieve a more complete understanding of neocortical brain functions in health and disease, we need to delineate the computations of specific cell populations and how they dynamically exert their impact on connected target neurons. Here, I propose to investigate the functions of neurons in layer-6 of primary visual cortex (V1) and their influence on connected neurons, i) in the lateral geniculate nucleus (LGN) of thalamus, and ii) to more superficially located V1 cells, during visual perception in non-human primates (NHP). My core hypothesis is that due to their unique connectivity with LGN on one hand and layer-4 of V1 on the other hand, layer-6 neurons are in an ideal position to facilitate the transmission of visual information from LGN to V1 when spatial attention is allocated to specific visual targets. The central aim of my investigations will be to delineate how the computations and network interactions of layer-6 neurons dynamically change during attention and ultimately lead to improved behavioral performance. To this end, selective targeting and manipulation of LGN projecting V1 layer-6 neurons will be enabled using the methods of optogenetics (ChR2) and viral delivery techniques. Methods to measure brain activity and assess the impact of optogenetic stimulation will include behavioral assessment, functional magnetic resonance imaging (fMRI) and extra-cellular multi-electrode electrophysiology. Data analysis will include measures of directed (functional and effective) connectivity and en-/decoding approaches using a (predictive coding) Bayesian inference framework. With this approach we will gain new insights into the basic principles of information flow in the visual system. Beyond their immediate impact on basic science, the results of the experiments will be contributing towards a better understanding of the diseased brain such as in schizophrenia or attention-deficit-hyperactivity (ADHD) syndrome.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Katharine A. Shapcott, Joscha T. Schmiedt, Richard C. Saunders, Alexander Maier, David A. Leopold, Michael C. Schmid Correlated activity of cortical neurons survives extensive removal of feedforward sensory input published pages: , ISSN: 2045-2322, DOI: 10.1038/srep34886 |
Scientific Reports 6/1 | 2019-05-29 |
| 2017 |
Phillipp Kurtz, Katharine A. Shapcott, Jochen Kaiser, Joscha T. Schmiedt, Michael C. Schmid The Influence of Endogenous and Exogenous Spatial Attention on Decision Confidence published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-06715-w |
Scientific Reports 7/1 | 2019-05-29 |
| 2018 |
Ricardo Kienitz, Joscha T. Schmiedt, Katharine A. Shapcott, Kleopatra Kouroupaki, Richard C. Saunders, Michael Christoph Schmid Theta Rhythmic Neuronal Activity and Reaction Times Arising from Cortical Receptive Field Interactions during Distributed Attention published pages: 2377-2387.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.05.086 |
Current Biology 28/15 | 2019-05-29 |
| 2017 |
Adriana Galvan, William R. Stauffer, Leah Acker, Yasmine El-Shamayleh, Ken-ichi Inoue, Shay Ohayon, Michael C. Schmid Nonhuman Primate Optogenetics: Recent Advances and Future Directions published pages: 10894-10903, ISSN: 0270-6474, DOI: 10.1523/jneurosci.1839-17.2017 |
The Journal of Neuroscience 37/45 | 2019-05-29 |
| 2016 |
Carsten Klein, Henry C. Evrard, Katharine A. Shapcott, Silke Haverkamp, Nikos K. Logothetis, Michael C. Schmid Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex published pages: 143-151, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.02.036 |
Neuron 90/1 | 2019-05-29 |
| 2017 |
Rikkert Hindriks, Joscha Schmiedt, Xerxes D. Arsiwalla, Alina Peter, Paul F. M. J. Verschure, Pascal Fries, Michael C. Schmid, Gustavo Deco Linear distributed source modeling of local field potentials recorded with intra-cortical electrode arrays published pages: e0187490, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0187490 |
PLOS ONE 12/12 | 2019-05-29 |
| 2018 |
Kacie Dougherty, Michael C. Schmid, Alexander Maier Binocular response modulation in the lateral geniculate nucleus published pages: , ISSN: 0021-9967, DOI: 10.1002/cne.24417 |
Journal of Comparative Neurology | 2019-05-29 |
| 2018 |
Michael Ortiz-Rios, Marcus Haag, Fabien Balezeau, Stephen Frey, Alex Thiele, Kathy Murphy, Michael Christoph Schmid Improved methods for MRI-compatible implants in nonhuman primates published pages: , ISSN: 0165-0270, DOI: 10.1016/j.jneumeth.2018.09.013 |
Journal of Neuroscience Methods | 2019-05-07 |
| 2018 |
Michael P. Milham, Lei Ai, Bonhwang Koo, Ting Xu, Céline Amiez, Fabien Balezeau, Mark G. Baxter, Erwin L.A. Blezer, Thomas Brochier, Aihua Chen, Paula L. Croxson, Christienne G. Damatac, Stanislas Dehaene, Stefan Everling, Damian A. Fair, Lazar Fleysher, Winrich Freiwald, Sean Froudist-Walsh, Timothy D. Griffiths, Carole Guedj, Fadila Hadj-Bouziane, Suliann Ben Hamed, Noam Harel, Bassem Hiba, Bechir Jarraya, Benjamin Jung, Sabine Kastner, P. Christiaan Klink, Sze Chai Kwok, Kevin N. Laland, David A. Leopold, Patrik Lindenfors, Rogier B. Mars, Ravi S. Menon, Adam Messinger, Martine Meunier, Kelvin Mok, John H. Morrison, Jennifer Nacef, Jamie Nagy, Michael Ortiz Rios, Christopher I. Petkov, Mark Pinsk, Colline Poirier, Emmanuel Procyk, Reza Rajimehr, Simon M. Reader, Pieter R. Roelfsema, David A. Rudko, Matthew F.S. Rushworth, Brian E. Russ, Jerome Sallet, Michael Christoph Schmid, Caspar M. Schwiedrzik, Jakob Seidlitz, Julien Sein, Amir Shmuel, Elinor L. Sullivan, Leslie Ungerleider, Alexander Thiele, Orlin S. Todorov, Doris Tsao, Zheng Wang, Charles R.E. Wilson, Essa Yacoub, Frank Q. Ye, Wilbert Zarco, Yong-di Zhou, Daniel S. Margulies, Charles E. Schroeder An Open Resource for Non-human Primate Imaging published pages: 61-74.e2, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.08.039 |
Neuron 100/1 | 2019-05-07 |
| 2018 |
Samson Chota, Canhuang Luo, Sébastien M. Crouzet, Léa Boyer, Ricardo Kienitz, Michael Christoph Schmid, Rufin VanRullen Rhythmic fluctuations of saccadic reaction time arising from visual competition published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-34252-7 |
Scientific Reports 8/1 | 2019-05-07 |
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