TB-ACCELERATE SIGNED
Integrating genomics, epidemiology and evolution to accelerate tuberculosis eradication
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the TB-ACCELERATE project. It provides you a very rough idea of what is the project "TB-ACCELERATE" about.
Project "TB-ACCELERATE" data sheet
The following table provides information about the project.
| Coordinator |
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Total cost | 1˙671˙875 € |
| EC max contribution | 1˙671˙875 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-07-01 to 2021-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS | ES (MADRID) | coordinator | 1˙275˙875.00 |
| 2 | FUNDACION PARA EL FOMENTO DE LA INVESTIGACION SANITARIA Y BIOMEDICA DE LA COMUNITAT VALENCIANA | ES (VALENCIA) | participant | 396˙000.00 |
Map
Project objective
'When the scale of the tuberculosis (TB) epidemic was highlighted by its declaration as a 'Global Emergency' by WHO in 1993, it was envisaged that the efficient use of existing tools would result in a progressive decline towards eradication. This has not occurred. At the current pace of decline in TB incidence the Millennium objective to eradicate it by 2050 will not be met. Predictions of epidemiological models were inaccurate and current control programs and technologies have shown their limitations to control the transmission of the disease. To overcome these limitations we need a technological, methodological and conceptual leap forward that can reveal the unknowns of TB epidemiology. I propose whole genome sequencing (WGS) as the technology that can mediate this advance. While WGS has been applied mostly to retrospective datasets I propose to use it in prospective samples from a low-burden region at a population scale. Genome information will fill the gap between epidemiology and evolution to have a direct impact on public health. This will allow to develop innovative methodologies to describe transmission at an unprecedented resolution and as a consequence to differentiate among risks factors associated to the bacteria, the host, the environment and their interactions. Elucidation of these factors will lead to better models used to design new strategies and accelerate global TB eradication. In addition, I will show how the real-time integration of data in public eHealth systems combined with in situ interventions will accelerate TB eradication. The strength of the project resides in its multidisciplinary approach to TB epidemiology that will provide answers to yet-out-of-reach questions. It will lead to improving health status at the local level as well as to epidemiological and control programs at a global scale. In summary, the project will open new ways to foster the long sought outcome of the tuberculosis community: TB eradication.'
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Helder Novais Bastos, Nuno S. Osório, Sebastien Gagneux, Iñaki Comas, Margarida Saraiva The Troika Host–Pathogen–Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01948 |
Frontiers in Immunology 8 | 2019-11-06 |
| 2017 |
L. Pérez-Lago, S. Izco, M. Herranz, G. Tudó, M. Carcelén, I. Comas, O. Sierra, J. González-MartÃn, M.J. Ruiz-Serrano, J. Eyene, E. Bouza, D. GarcÃa de Viedma A novel strategy based on genomics and specific PCR reveals how a multidrug-resistant Mycobacterium tuberculosis strain became prevalent in Equatorial Guinea 15 years after its emergence published pages: 92-97, ISSN: 1198-743X, DOI: 10.1016/j.cmi.2016.10.006 |
Clinical Microbiology and Infection 23/2 | 2019-11-06 |
| 2017 |
Iñaki Comas Genomic epidemiology of tuberculosis published pages: 79-93, ISSN: , DOI: 10.1007/978-3-319-64371-7_4 |
2019-11-06 | |
| 2016 |
Giuseppe D\'Auria, Eduard Torrents, Marina Luquin, Iñaki Comas, Esther Julián Draft Genome Sequence of Mycobacterium brumae ATCC 51384 published pages: e00237-16, ISSN: 2169-8287, DOI: 10.1128/genomeA.00237-16 |
Genome Announcements 4/2 | 2019-11-06 |
| 2016 |
David Stucki, Daniela Brites, Leïla Jeljeli, Mireia Coscolla, Qingyun Liu, Andrej Trauner, Lukas Fenner, Liliana Rutaihwa, Sonia Borrell, Tao Luo, Qian Gao, Midori Kato-Maeda, Marie Ballif, Matthias Egger, Rita Macedo, Helmi Mardassi, Milagros Moreno, Griselda Tudo Vilanova, Janet Fyfe, Maria Globan, Jackson Thomas, Frances Jamieson, Jennifer L Guthrie, Adwoa Asante-Poku, Dorothy Yeboah-Manu, Eddie Wampande, Willy Ssengooba, Moses Joloba, W Henry Boom, Indira Basu, James Bower, Margarida Saraiva, Sidra E G Vasconcellos, Philip Suffys, Anastasia Koch, Robert Wilkinson, Linda Gail-Bekker, Bijaya Malla, Serej D Ley, Hans-Peter Beck, Bouke C de Jong, Kadri Toit, Elisabeth Sanchez-Padilla, Maryline Bonnet, Ana Gil-Brusola, Matthias Frank, Veronique N Penlap Beng, Kathleen Eisenach, Issam Alani, Perpetual Wangui Ndung\'u, Gunturu Revathi, Florian Gehre, Suriya Akter, Francine Ntoumi, Lynsey Stewart-Isherwood, Nyanda E Ntinginya, Andrea Rachow, Michael Hoelscher, Daniela Maria Cirillo, Girts Skenders, Sven Hoffner, Daiva Bakonyte, Petras Stakenas, Roland Diel, Valeriu Crudu, Olga Moldovan, Sahal Al-Hajoj, Larissa Otero, Francesca Barletta, E Jane Carter, Lameck Diero, Philip Supply, Iñaki Comas, Stefan Niemann, Sebastien Gagneux Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages published pages: 1535-1543, ISSN: 1061-4036, DOI: 10.1038/ng.3704 |
Nature Genetics 48/12 | 2019-11-06 |
| 2015 |
Iñaki Comas, Elena Hailu, Teklu Kiros, Shiferaw Bekele, Wondale Mekonnen, Balako Gumi, Rea Tschopp, Gobena Ameni, R. Glyn Hewinson, Brian D. Robertson, Galo A. Goig, David Stucki, Sebastien Gagneux, Abraham Aseffa, Douglas Young, Stefan Berg Population Genomics of Mycobacterium tuberculosis in Ethiopia Contradicts the Virgin Soil Hypothesis for Human Tuberculosis in Sub-Saharan Africa published pages: 3260-3266, ISSN: 0960-9822, DOI: 10.1016/j.cub.2015.10.061 |
Current Biology 25/24 | 2019-11-06 |
| 2016 |
Laura Pérez-Lago, Miguel MartÃnez-Lirola, Sergio GarcÃa, Marta Herranz, Igor Mokrousov, Iñaki Comas, Llúcia MartÃnez-Priego, Emilio Bouza, DarÃo GarcÃa-de-Viedma Urgent Implementation in a Hospital Setting of a Strategy To Rule Out Secondary Cases Caused by Imported Extensively Drug-Resistant Mycobacterium tuberculosis Strains at Diagnosis published pages: 2969-2974, ISSN: 0095-1137, DOI: 10.1128/JCM.01718-16 |
Journal of Clinical Microbiology 54/12 | 2019-11-06 |
| 2016 |
Mariateresa Coppola, Krista E. van Meijgaarden, Kees L. M. C. Franken, Susanna Commandeur, Gregory Dolganov, Igor Kramnik, Gary K. Schoolnik, Inaki Comas, Ole Lund, Corine Prins, Susan J. F. van den Eeden, Gro E. Korsvold, Fredrik Oftung, Annemieke Geluk, Tom H. M. Ottenhoff New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles published pages: , ISSN: 2045-2322, DOI: 10.1038/srep37793 |
Scientific Reports 6/1 | 2019-11-06 |
| 2017 |
Paolo Miotto, Belay Tessema, Elisa Tagliani, Leonid Chindelevitch, Angela M. Starks, Claudia Emerson, Debra Hanna, Peter S. Kim, Richard Liwski, Matteo Zignol, Christopher Gilpin, Stefan Niemann, Claudia M. Denkinger, Joy Fleming, Robin M. Warren, Derrick Crook, James Posey, Sebastien Gagneux, Sven Hoffner, Camilla Rodrigues, Iñaki Comas, David M. Engelthaler, Megan Murray, David Alland, Leen Rigouts, Christoph Lange, Keertan Dheda, Rumina Hasan, Uma Devi K. Ranganathan, Ruth McNerney, Matthew Ezewudo, Daniela M. Cirillo, Marco Schito, Claudio U. Köser, Timothy C. Rodwell A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis published pages: 1701354, ISSN: 0903-1936, DOI: 10.1183/13993003.01354-2017 |
European Respiratory Journal 50/6 | 2019-11-06 |
| 2017 |
Yurena Navarro, Laura Pérez-Lago, Marta Herranz, Olalla Sierra, Iñaki Comas, Javier Sicilia, Emilio Bouza, DarÃo GarcÃa de Viedma In-Depth Characterization and Functional Analysis of Clonal Variants in a Mycobacterium tuberculosis Strain Prone to Microevolution published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.00694 |
Frontiers in Microbiology 8 | 2019-11-06 |
| 2018 |
CRyPTIC Consortium and the 100,000 Genomes Project, Allix-Béguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, Cabibbe AM, Cancino-Muñoz I, Caulfield MJ, Chaiprasert A, Cirillo DM, Clifton DA, Comas I, Crook DW, De Filippo MR, de Neeling H, Diel R, Drobniewski FA, Faksri K, Farhat MR, Fleming J, Fowler P, Fowler TA, Gao Q, Gardy J, Gascoyne-Binzi D, Gibertoni-Cruz AL, Gil-Brusola A, Golubchik T, Gonzalo X, Grandjean L, He G, Guthrie JL, Hoosdally S, Hunt M, Iqbal Z, Ismail N, Johnston J, Khanzada FM, Khor CC, Kohl TA, Kong C, Lipworth S, Liu Q, Maphalala G, Martinez E, Mathys V, Merker M, Miotto P, Mistry N, Moore DAJ, Murray M, Niemann S, Omar SV, Ong RT, Peto TEA, Posey JE, Prammananan T, Pym A, Rodrigues C, Rodrigues M, Rodwell T, Rossolini GM, Sánchez Padilla E, Schito M, Shen X, Shendure J, Sintchenko V, Sloutsky A, Smith EG, Snyder M, Soetaert K, Starks AM, Supply P, Suriyapol P, Tahseen S, Tang P, Teo YY, Thuong TNT, Thwaites G, Tortoli E, van Soolingen D, Walker AS, Walker TM, Wilcox M, Wilson DJ, Wyllie D, Yang Y, Zhang H, Zhao Y, Zhu B. Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing published pages: 1403-1415, ISSN: 0028-4793, DOI: 10.1056/NEJMoa1800474 |
New England Journal of Medicine 379/15 | 2019-11-06 |
| 2018 |
Marta Herranz, Ilva Pole, Iveta Ozere, Ãlvaro Chiner-Oms, Miguel MartÃnez-Lirola, Felipe Pérez-GarcÃa, Paloma Gijón, MarÃa Jesús Ruiz Serrano, Laura Clotet Romero, Oscar Cuevas, Iñaki Comas, Emilio Bouza, Laura Pérez-Lago, DarÃo GarcÃa-de-Viedma Mycobacterium tuberculosis Acquires Limited Genetic Diversity in Prolonged Infections, Reactivations and Transmissions Involving Multiple Hosts published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.02661 |
Frontiers in Microbiology 8 | 2019-11-06 |
| 2018 |
Ãlvaro Chiner-Oms, Fernando González-Candelas, Iñaki Comas Gene expression models based on a reference laboratory strain are poor predictors of Mycobacterium tuberculosis complex transcriptional diversity published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-22237-5 |
Scientific Reports 8/1 | 2019-11-06 |
| 2018 |
Matthew Ezewudo, Amanda Borens, Ãlvaro Chiner-Oms, Paolo Miotto, Leonid Chindelevitch, Angela M. Starks, Debra Hanna, Richard Liwski, Matteo Zignol, Christopher Gilpin, Stefan Niemann, Thomas Andreas Kohl, Robin M. Warren, Derrick Crook, Sebastien Gagneux, Sven Hoffner, Camilla Rodrigues, Iñaki Comas, David M. Engelthaler, David Alland, Leen Rigouts, Christoph Lange, Keertan Dheda, Rumina Hasan, Ruth McNerney, Daniela M. Cirillo, Marco Schito, Timothy C. Rodwell, James Posey Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33731-1 |
Scientific Reports 8/1 | 2019-11-06 |
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