Explore the words cloud of the STEMMING-FROM-NERVE project. It provides you a very rough idea of what is the project "STEMMING-FROM-NERVE" about.
The following table provides information about the project.
Coordinator |
MEDIZINISCHE UNIVERSITAET WIEN
Organization address contact info |
Coordinator Country | Austria [AT] |
Project website | http://www.adameykolab.eu/ |
Total cost | 1˙964˙338 € |
EC max contribution | 1˙964˙338 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2014-CoG |
Funding Scheme | ERC-COG |
Starting year | 2015 |
Duration (year-month-day) | from 2015-08-01 to 2020-07-31 |
Take a look of project's partnership.
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1 | MEDIZINISCHE UNIVERSITAET WIEN | AT (WIEN) | coordinator | 1˙964˙338.00 |
Recently we discovered an entirely new phenomenon in developmental biology – targeted recruitment of stem cells from the pervasive peripheral nerves. For example, we demonstrated that majority of melanocytes – our pigment cells, are born from peripheral glial cells. To further extend this far-reaching principle we will use tooth development as a model. Current opinion holds that sensory innervation of the tooth has a minor or no role in making a structure of the tooth during development and adulthood. On the contrary, our preliminary data strongly suggest that sensory nerve contributes pulp cells and matrix-producing cells of odontoblast lineage to the growing tooth. Our hypothesis implies that nerve-associated glial cells can be recruited from the nerve by unknown molecules presented inside of the tooth environment, and that these recruited cells are capable of producing pulp cells and odontoblasts.
WE PROPOSE TO ADDRESS THE ROLE OF A SENSORY NERVE AS A PROVIDER OF DENTAL STEM CELLS DURING THE DEVELOPMENT, ADULTHOOD AND REGENERATION.
To experimentally address our hypothesis we developed innovative and powerful approaches: we will use advanced genetics tracing with multicolor reporters, completely novel unconventional individual cell transcriptome analysis, transgenic mice with cell type-specific modifications in signaling, microsurgery and grafting, and, finally, 3D-imaging of developing tooth structures.
This project is interesting to a wide community of scientists because it addresses a novel function of peripheral nervous system which is contributing stem cells as building blocks to local tissues in development and regeneration. The MEDICAL IMPLICATION of this project will include better understanding of tooth regeneration providing new approaches to dentin recovery and tooth restoration following trauma.
year | authors and title | journal | last update |
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2017 |
Maria Eleni Kastriti, Igor Adameyko Specification, plasticity and evolutionary origin of peripheral glial cells published pages: 196-202, ISSN: 0959-4388, DOI: 10.1016/j.conb.2017.11.004 |
Current Opinion in Neurobiology 47 | 2020-04-07 |
2017 |
Marketa Kaucka, Igor Adameyko Evolution and development of the cartilaginous skull: From a lancelet towards a human face published pages: , ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2017.12.007 |
Seminars in Cell & Developmental Biology | 2020-04-07 |
2018 |
Alessandro Furlan, Igor Adameyko Schwann cell precursor: a neural crest cell in disguise? published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2018.02.008 |
Developmental Biology | 2020-04-07 |
2017 |
Alessandro Furlan, Vyacheslav Dyachuk, Maria Eleni Kastriti, Laura Calvo-Enrique, Hind Abdo, Saida Hadjab, Tatiana Chontorotzea, Natalia Akkuratova, Dmitry Usoskin, Dmitry Kamenev, Julian Petersen, Kazunori Sunadome, Fatima Memic, Ulrika Marklund, Kaj Fried, Piotr Topilko, Francois Lallemend, Peter V. Kharchenko, Patrik Ernfors, Igor Adameyko Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla published pages: eaal3753, ISSN: 0036-8075, DOI: 10.1126/science.aal3753 |
Science 357/6346 | 2020-04-07 |
2017 |
Julian Petersen, Igor Adameyko Nerve-associated neural crest: peripheral glial cells generate multiple fates in the body published pages: 10-14, ISSN: 0959-437X, DOI: 10.1016/j.gde.2017.02.006 |
Current Opinion in Genetics & Development 45 | 2020-04-07 |
2017 |
Jan Krivanek, Igor Adameyko, Kaj Fried Heterogeneity and Developmental Connections between Cell Types Inhabiting Teeth published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2017.00376 |
Frontiers in Physiology 8 | 2020-04-07 |
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