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BeadDiagnosis

Prognosis and Diagnosis of Protein Misfolding Diseases by Seeded Aggregation in Microspheres

Total Cost €

EC-Contrib. €

Partnership

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BeadDiagnosis project word cloud

Explore the words cloud of the BeadDiagnosis project. It provides you a very rough idea of what is the project "BeadDiagnosis" about.

microdroplets protein biological resolve poc satisfy quantitative readout context patients progression demands flexible immediately question human mouse capital extends amyloidogenesis brain drosophila aggregation serum misfolding reflects analysed strengthen diseases found detection parkinson neurological there amyloid brains utility data microfluidic medical alzheimer explore reproducible prognosis assays fly disorders disease rapid formed fruit samples report diagnosis assay venture precursors

Project "BeadDiagnosis" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	149˙972 €
EC max contribution	149˙972 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-PoC
Funding Scheme	ERC-POC
Starting year	2015
Duration (year-month-day)	from 2015-08-01 to 2017-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	149˙972.00

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Project objective

There is currently no early detection system for neurological protein misfolding disorders (such as Alzheimer's and Parkinson's diseases) that would satisfy the demands for rapid, quantitative, flexible, and reproducible assays to study amyloidogenesis in biological samples. We will explore the potential of aggregation assays in microdroplets that are formed in microfluidic devices. We have found that the readout of this assay reflects the disease progression, when samples of Drosophila fruit fly brains and mouse brain and serum are analysed. We will use this PoC project explore the utility of this technology to report on aggregation of amyloid precursors in human biological samples, to test whether the potential of this technology extends to patients diagnosis and prognosis. Such data would resolve the question whether our early diagnosis system is immediately useful in a medical context and strengthen the case for venture capital funding.

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