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ZAUBERKUGEL SIGNED

Fulfilling Paul Ehrlich’s Dream: therapeutics with activity on demand

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ZAUBERKUGEL project word cloud

Explore the words cloud of the ZAUBERKUGEL project. It provides you a very rough idea of what is the project "ZAUBERKUGEL" about.

pharmacotherapy pharmaceutical strategy cytotoxic points activated time causing killed armed academic therapeutic prevent paul cytokines injection procedure realized outline single serious antibody relies created preferentially arming first potency considerable toxicities intense concentration profiled normal tumor escalation compound antibodies ehrlich assembly diseases unacceptable unprecedented acceptably certain treatment cures extremely ideal cancer regimens dose tissues selective unfortunately site disease payloads innovative cognate molecules suitable monoclonal curative hold induce proteomic binding bullet cells affinity hla diseased toxin postulate release therapy made industrial covalent potentially debilitating scientist invention inflammatory active stepwise sparing agent magic organs demand conditional agents selectivity zauberkugel drugs chronic generation selectively conditionally peptidome

Project "ZAUBERKUGEL" data sheet

The following table provides information about the project.

Coordinator	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	http://www.biomacromolecules.ethz.ch
Total cost	2˙000˙000 €
EC max contribution	2˙000˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-ADG
Funding Scheme	ERC-ADG
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	coordinator	2˙000˙000.00

Map

Project objective

'Paul Ehrlich was the first scientist to postulate that if a compound could be made that selectively targeted disease-causing cells, then this agent could be used for the delivery of a toxin, which would enable a pharmacotherapy of unprecedented potency and selectivity. With this procedure, a 'magic bullet' (Zauberkugel, his term for an ideal therapeutic agent) would be created, that killed diseased cells while sparing normal tissues. The concept of a 'magic bullet' was to some extent realized by the invention of monoclonal antibodies, as these molecules provide a very specific binding affinity to their cognate target. However, monoclonal antibodies used as single agents are typically not able to induce cures for cancer or chronic inflammatory diseases. More recently, intense academic and industrial research activities have aimed at “arming” monoclonal antibodies with drugs or cytokines, in order to preferentially deliver these therapeutic payloads to the site of disease. Unfortunately, in most cases, 'armed' antibody products still cause unacceptable toxicities, which prevent escalation to potentially curative dose regimens. In this Project, I outline a therapeutic strategy, which relies on the use of extremely specific tumor targeting agents, for the selective delivery of payloads, which can be conditionally activated at the site of disease. Methodologies for the conditional generation of active payloads include the stepwise non-covalent assembly of cytokines and the controlled release of cytotoxic drugs at suitable time points after injection, when the concentration of therapeutic agent in normal organs is acceptably low. Response to therapy will be profiled using innovative proteomic methodologies, based on HLA-peptidome analysis. Pharmaceutical agents with “activity on demand” hold a considerable potential not only for the therapy of cancer, but also for the treatment of other serious diseases, including certain highly debilitating chronic inflammatory condition'

Publications

List of publications.
year	authors and title	journal	last update
2020	Patrizia Murer, Louis PlÃ¼ss, Dario Neri A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis published pages: 1714371, ISSN: 1942-0870, DOI: 10.1080/19420862.2020.1714371	mAbs 12/1	2020-04-24
2020	Jacqueline Mock, Christian Pellegrino, Dario Neri A universal reporter cell line for bioactivity evaluation of engineered cytokine products published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-020-60182-4	Scientific Reports 10/1	2020-04-24
2019	Sheila Dakhel, Tiziano Ongaro, Baptiste Gouyou, Mattia Matasci, Alessandra Villa, Dario Neri, Samuele Cazzamalli Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.27320	Oncotarget 10/62	2020-02-06
2019	Dario Neri Antibodyâ€“Cytokine Fusions: Versatile Products for the Modulation of Anticancer Immunity published pages: 348-354, ISSN: 2326-6066, DOI: 10.1158/2326-6066.cir-18-0622	Cancer Immunology Research 7/3	2020-02-06
2019	AdriÃ¡n Gironda-MartÃnez, Dario Neri, Florent Samain, Etienne J. Donckele DNA-Compatible Diazo-Transfer Reaction in Aqueous Media Suitable for DNA-Encoded Chemical Library Synthesis published pages: 9555-9558, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.9b03726	Organic Letters 21/23	2020-02-06
2019	Cornelia Hutmacher, NicolÃ¡s Gonzalo NÃºÃ±ez, Anna Rita Liuzzi, Burkhard Becher, Dario Neri Targeted Delivery of IL2 to the Tumor Stroma Potentiates the Action of Immune Checkpoint Inhibitors by Preferential Activation of NK and CD8 + T Cells published pages: 572-583, ISSN: 2326-6066, DOI: 10.1158/2326-6066.cir-18-0566	Cancer Immunology Research 7/4	2020-02-06
2019	Emanuele Puca, Philipp Probst, Marco Stringhini, Patrizia Murer, Giovanni Pellegrini, Samuele Cazzamalli, Cornelia Hutmacher, Baptiste Gouyou, Sarah Wulhfard, Mattia Matasci, Alessandra Villa, Dario Neri The antibodyâ€based delivery of interleukinâ€12 to solid tumors boosts NK and CD8 + T cell activity and synergizes with immune checkpoint inhibitors published pages: , ISSN: 0020-7136, DOI: 10.1002/ijc.32603	International Journal of Cancer	2020-02-06
2019	Emanuele Puca, Roberto De Luca, Frauke Seehusen, Josep Maria MonnÃ© Rodriguez, Dario Neri Comparative evaluation of bolus and fractionated administration modalities for two antibody-cytokine fusions in immunocompetent tumor-bearing mice published pages: , ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.11.036	Journal of Controlled Release	2020-02-06
2019	Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, TÃ¢nia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, GonÃ§alo J. L. Bernardes, JoÃ£o T. Barata A fully human anti-IL-7RÎ± antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia published pages: 2155-2168, ISSN: 0887-6924, DOI: 10.1038/s41375-019-0434-8	Leukemia 33/9	2020-02-06
2018	Roberto De Luca, Dario Neri Potentiation of PD-L1 blockade with a potency-matched dual cytokineâ€“antibody fusion protein leads to cancer eradication in BALB/c-derived tumors but not in other mouse strains published pages: 1381-1391, ISSN: 0340-7004, DOI: 10.1007/s00262-018-2194-0	Cancer Immunology, Immunotherapy 67/9	2020-02-04
2019	Anja Sophie Schmid, Dario Neri Design and characterisation of a novel interleukin-15 receptor alpha fusion protein and analysis of interleukin-15 complexation published pages: e0219313, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0219313	PLOS ONE 14/7	2020-02-04
2018	Cazzamalli, Samuele; Figueras, Eduard; PethÅ‘, Lilla; BorbÃ©ly, Adina; SteinkÃ¼hler, Christian; Neri, Dario; Sewald, Norbert In Vivo Antitumor Activity of a Novel Acetazolamideâ€“Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas published pages: 14726-14731, ISSN: 2470-1343, DOI: 10.3929/ethz-b-000304161	ACS Omega, 3 (11) 1	2020-02-04
2018	Simon Schwager, Silvana Renner, Teresa Hemmerle, Sinem Karaman, Steven T. Proulx, Roman Fetz, Alexandra Michaela Golding-Ochsenbein, Philipp Probst, Cornelia Halin, Dario Neri, Michael Detmar Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.124850	JCI Insight 3/23	2020-01-30
2019	Barbara Ziffels, Marco Stringhini, Philipp Probst, Tim Fugmann, Theo Sturm, Dario Neri Antibody-Based Delivery of Cytokine Payloads to Carbonic Anhydrase IX Leads to Cancer Cures in Immunocompetent Tumor-Bearing Mice published pages: 1544-1554, ISSN: 1535-7163, DOI: 10.1158/1535-7163.mct-18-1301	Molecular Cancer Therapeutics 18/9	2020-01-30
2019	Patrizia Murer, Dario Neri Antibody-cytokine fusion proteins: A novel class of biopharmaceuticals for the therapy of cancer and of chronic inflammation published pages: 42-53, ISSN: 1871-6784, DOI: 10.1016/j.nbt.2019.04.002	New Biotechnology 52	2020-01-30
2019	Patrizia Murer, Jonathan D. Kiefer, Louis PlÃ¼ss, Mattia Matasci, Sandra L. BlÃ¼mich, Marco Stringhini, Dario Neri Targeted Delivery of TNF Potentiates theÂ Antibody-Dependent Cell-Mediated Cytotoxicity of an Anti-Melanoma Immunoglobulin published pages: 1339-1348, ISSN: 0022-202X, DOI: 10.1016/j.jid.2018.11.028	Journal of Investigative Dermatology 139/6	2020-01-30
2019	Barbara Ziffels, Anna GrÃ¶tsch, Lubna Al-Bayati, Dario Neri Targeted delivery of calreticulin to ED-A fibronectin leads to tumor-growth retardation published pages: 53-58, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2018.12.007	Journal of Biotechnology 290	2020-01-30
2019	Cornelia Hutmacher, Dario Neri Antibody-cytokine fusion proteins: Biopharmaceuticals with immunomodulatory properties for cancer therapy published pages: 67-91, ISSN: 0169-409X, DOI: 10.1016/j.addr.2018.09.002	Advanced Drug Delivery Reviews 141	2020-01-30
2019	Roberto De Luca, Baptiste Gouyou, Tiziano Ongaro, Alessandra Villa, Barbara Ziffels, Alessandro Sannino, Gianluca Buttinoni, Simone Galeazzi, Mirko Mazzacuva, Dario Neri A Novel Fully-Human Potency-Matched Dual Cytokine-Antibody Fusion Protein Targets Carbonic Anhydrase IX in Renal Cell Carcinomas published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2019.01228	Frontiers in Oncology 9	2020-01-30
2019	Cornelia Hutmacher, Laura Volta, Francesco Rinaldi, Patrizia Murer, Renier Myburgh, Markus G. Manz, Dario Neri Development of a novel fully-human anti-CD123 antibody to target acute myeloid leukemia published pages: 106178, ISSN: 0145-2126, DOI: 10.1016/j.leukres.2019.106178	Leukemia Research 84	2020-01-30
2018	Roberto De Luca, Paul Kachel, Klara Kropivsek, Berend Snijder, Markus G Manz, Dario Neri A novel dual-cytokineâ€“antibody fusion protein for the treatment of CD38-positive malignancies published pages: 173-179, ISSN: 1741-0126, DOI: 10.1093/protein/gzy015	Protein Engineering, Design and Selection 31/5	2020-01-30
2019	Alessandro Sannino, Elena Gabriele, Martina Bigatti, Sara Mulatto, Jacopo Piazzi, JÃ¶rg Scheuermann, Dario Neri, Etienne J. Donckele, Florent Samain Quantitative Assessment of Affinity Selection Performance by Using DNAâ€Encoded Chemical Libraries published pages: 955-962, ISSN: 1439-4227, DOI: 10.1002/cbic.201800766	ChemBioChem 20/7	2020-01-30
2019	Philipp Probst, Marco Stringhini, Danilo Ritz, Tim Fugmann, Dario Neri Antibody-based Delivery of TNF to the Tumor Neovasculature Potentiates the Therapeutic Activity of a Peptide Anticancer Vaccine published pages: 698-709, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-18-1728	Clinical Cancer Research 25/2	2020-01-30
2017	Gunther Zimmermann, Yizhou Li, Ulrike Rieder, Martin Mattarella, Dario Neri, JÃ¶rg Scheuermann Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201600637	ChemBioChem	2019-07-05
2016	Andreas Gloger, Danilo Ritz, Tim Fugmann, Dario Neri Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes published pages: 1377-1393, ISSN: 0340-7004, DOI: 10.1007/s00262-016-1897-3	Cancer Immunology, Immunotherapy 65/11	2019-07-05
2018	Samuele Cazzamalli, Barbara Ziffels, Fontaine Widmayer, Patrizia Murer, Giovanni Pellegrini, Francesca Pretto, Sarah Wulhfard, Dario Neri Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2 published pages: 3656-3667, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-17-3457	Clinical Cancer Research 24/15	2019-07-05
2017	Yizhou Li, Gunther Zimmermann, JÃ¶rg Scheuermann, Dario Neri Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA-Encoded Chemical Library Selections published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201600626	ChemBioChem	2019-07-05
2016	Samuele Cazzamalli, Alberto Dal Corso, Dario Neri Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell Carcinoma published pages: 2926-2935, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-16-0283	Molecular Cancer Therapeutics 15/12	2019-07-05
2017	Tim Fugmann, Adriana Sofron, Danilo Ritz, Franziska Bootz, Dario Neri The MHC Class II Immunopeptidome of Lymph Nodes in Health and in Chemically Induced Colitis published pages: 1357-1364, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1601157	The Journal of Immunology 198/3	2019-07-05
2018	Yizhou Li, Roberto De Luca, Samuele Cazzamalli, Francesca Pretto, Davor Bajic, JÃ¶rg Scheuermann, Dario Neri Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold published pages: 441-448, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0017-8	Nature Chemistry 10/4	2019-07-05
2016	Danilo Ritz, Andreas Gloger, Benjamin Weide, Claus Garbe, Dario Neri, Tim Fugmann High-sensitivity HLA class I peptidome analysis enables a precise definition of peptide motifs and the identification of peptides from cell lines and patientsâ€™ sera published pages: n/a-n/a, ISSN: 1615-9853, DOI: 10.1002/pmic.201500445	PROTEOMICS	2019-07-05
2018	Danilo Ritz, Emiliano Sani, Hanna Debiec, Pierre Ronco, Dario Neri, Tim Fugmann Membranal and blood-soluble HLA class II peptidome analyses using data-dependent and independent acquisition published pages: , ISSN: 1615-9853, DOI: 10.1002/pmic.201700246	PROTEOMICS	2019-07-05
2018	Nicholas Favalli, Stefan Biendl, Marco Hartmann, Jacopo Piazzi, Filippo Sladojevich, Susanne GrÃ¤slund, Peter J. Brown, Katja NÃ¤reoja, Herwig SchÃ¼ler, JÃ¶rg Scheuermann, Raphael Franzini, Dario Neri A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition published pages: 1303-1307, ISSN: 1860-7179, DOI: 10.1002/cmdc.201800193	ChemMedChem 13/13	2019-07-05
2017	Alberto Dal Corso, Samuele Cazzamalli, RÃ©my GÃ©bleux, Martin Mattarella, Dario Neri Protease-Cleavable Linkers Modulate the Anticancer Activity of Noninternalizing Antibodyâ€“Drug Conjugates published pages: 1826-1833, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.7b00304	Bioconjugate Chemistry 28/7	2019-07-05
2017	Samuele Cazzamalli, Alberto Dal Corso, Dario Neri Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma published pages: 39-45, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2016.11.023	Journal of Controlled Release 246	2019-07-05
2018	Barbara Ziffels, Francesca Pretto, Dario Neri Intratumoral administration of IL2- and TNF-based fusion proteins cures cancer without establishing protective immunity published pages: 177-188, ISSN: 1750-743X, DOI: 10.2217/imt-2017-0119	Immunotherapy 10/3	2019-07-05
2018	Anja Sophie Schmid, Teresa Hemmerle, Francesca Pretto, Anja Kipar, Dario Neri Antibody-based targeted delivery of interleukin-4 synergizes with dexamethasone for the reduction of inflammation in arthritis published pages: , ISSN: 1462-0324, DOI: 10.1093/rheumatology/kex447	Rheumatology	2019-07-05
2016	Yizhou Li, Elena Gabriele, Florent Samain, Nicholas Favalli, Filippo Sladojevich, JÃ¶rg Scheuermann, Dario Neri Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial Libraries published pages: 438-443, ISSN: 2156-8952, DOI: 10.1021/acscombsci.6b00058	ACS Combinatorial Science 18/8	2019-07-05
2017	Samuele Cazzamalli, Alberto Dal Corso, Dario Neri Targeted Delivery of Cytotoxic Drugs: Challenges, Opportunities and New Developments published pages: 712-715, ISSN: 0009-4293, DOI: 10.2533/chimia.2017.712	CHIMIA International Journal for Chemistry 71/10	2019-07-05
2017	Benjamin Weide, Dario Neri, Giuliano Elia Intralesional treatment of metastatic melanoma: a review of therapeutic options published pages: , ISSN: 0340-7004, DOI: 10.1007/s00262-016-1952-0	Cancer Immunology, Immunotherapy	2019-07-05
2018	De Luca R, Kachel P, Kropivsek K, Snijder B, Manz MG, Neri D OUP accepted manuscript published pages: , ISSN: 1741-0126, DOI: 10.1093/protein/gzy015	Protein Engineering, Design, and Selection	2019-07-05
2018	Dario Neri, Richard A. Lerner DNA-Encoded Chemical Libraries: A Selection System Based On Endowing Organic Compounds with Amplifiable Information published pages: , ISSN: 0066-4154, DOI: 10.1146/annurev-biochem-062917-012550	Annual Review of Biochemistry 87/1	2019-07-05
2016	Dario Venetz, Danil Koovely, Bruce Weder, Dario Neri Targeted Reconstitution of Cytokine Activity upon Antigen Binding using Split Cytokine Antibody Fusion Proteins published pages: 18139-18147, ISSN: 0021-9258, DOI: 10.1074/jbc.M116.737734	Journal of Biological Chemistry 291/35	2019-07-05
2017	Alberto Dal Corso, RÃ©my GÃ©bleux, Patrizia Murer, Alex Soltermann, Dario Neri A non-internalizing antibody-drug conjugate based on an anthracycline payload displays potent therapeutic activity in vivo published pages: 211-218, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2017.08.040	Journal of Controlled Release 264	2019-07-05
2016	F. Bootz, D. Venetz, B. Ziffels, D. Neri Different tissue distribution properties for glycosylation variants of fusion proteins containing the p40 subunit of murine interleukin-12 published pages: 445-455, ISSN: 1741-0126, DOI: 10.1093/protein/gzw038	Protein Engineering Design and Selection 29/10	2019-07-05
2017	Danilo Ritz, Andreas Gloger, Dario Neri, Tim Fugmann Purification of soluble HLA class I complexes from human serum or plasma deliver high quality immuno peptidomes required for biomarker discovery published pages: 1600364, ISSN: 1615-9853, DOI: 10.1002/pmic.201600364	PROTEOMICS 17/1-2	2019-07-05
2016	Jonathan D. Kiefer, Dario Neri Immunocytokines and bispecific antibodies: two complementary strategies for the selective activation of immune cells at the tumor site published pages: 178-192, ISSN: 0105-2896, DOI: 10.1111/imr.12391	Immunological Reviews 270/1	2019-07-05
2017	Philipp Probst, Janine Kopp, Annette Oxenius, Mario P. Colombo, Danilo Ritz, Tim Fugmann, Dario Neri Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8 + T-cell Recognition of a Retroviral Antigen published pages: 3644-3654, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-16-2946	Cancer Research 77/13	2019-07-05
2015	R. Gebleux, S. Wulhfard, G. Casi, D. Neri Antibody Format and Drug Release Rate Determine the Therapeutic Activity of Noninternalizing Antibody-Drug Conjugates published pages: 2606-2612, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-15-0480	Molecular Cancer Therapeutics 14/11	2019-07-05
2017	Gunther Zimmermann, Ulrike Rieder, Davor Bajic, Sara Vanetti, Apirat Chaikuad, Stefan Knapp, JÃ¶rg Scheuermann, Martin Mattarella, Dario Neri A Specific and Covalent JNK-1 Ligand Selected from an Encoded Self-Assembling Chemical Library published pages: 8152-8155, ISSN: 0947-6539, DOI: 10.1002/chem.201701644	Chemistry - A European Journal 23/34	2019-07-05
2018	Samuele Cazzamalli, Alberto Dal Corso, Fontaine Widmayer, Dario Neri Chemically Defined Antibodyâ€“ and Small Moleculeâ€“Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis published pages: 1617-1621, ISSN: 0002-7863, DOI: 10.1021/jacs.7b13361	Journal of the American Chemical Society 140/5	2019-07-05
2018	Nicholas Favalli, Gabriele Bassi, JÃ¶rg Scheuermann, Dario Neri DNA-encoded chemical libraries - achievements and remaining challenges published pages: 2168-2180, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13068	FEBS Letters 592/12	2019-07-05
2016	Franziska Bootz, Dario Neri Immunocytokines: a novel class of products for the treatment of chronic inflammation and autoimmune conditions published pages: 180-189, ISSN: 1359-6446, DOI: 10.1016/j.drudis.2015.10.012	Drug Discovery Today 21/1	2019-07-05
2017	Roberto De Luca, Alex Soltermann, Francesca Pretto, Catherine Pemberton-Ross, Giovanni Pellegrini, Sarah Wulhfard, Dario Neri Potency-matched Dual Cytokineâ€“Antibody Fusion Proteins for Cancer Therapy published pages: 2442-2451, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-17-0211	Molecular Cancer Therapeutics 16/11	2019-07-05
2017	RÃ©my GÃ©bleux, Marco Stringhini, Ruben Casanova, Alex Soltermann, Dario Neri Non-internalizing antibody-drug conjugates display potent anti-cancer activity upon proteolytic release of monomethyl auristatin E in the subendothelial extracellular matrix published pages: 1670-1679, ISSN: 0020-7136, DOI: 10.1002/ijc.30569	International Journal of Cancer 140/7	2019-07-05
2017	Danilo Ritz, Jonny Kinzi, Dario Neri, Tim Fugmann Data-Independent Acquisition of HLA Class I Peptidomes on the Q Exactive Mass Spectrometer Platform published pages: 1700177, ISSN: 1615-9853, DOI: 10.1002/pmic.201700177	PROTEOMICS 17/19	2019-07-05

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