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Opendata, web and dolomites

PIPPI SIGNED

Protein-excipient Interactions and Protein-Protein Interactions in formulation

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

PIPPI project word cloud

Explore the words cloud of the PIPPI project. It provides you a very rough idea of what is the project "PIPPI" about.

combined scientists turn expertise interplay potentially chronic securing susceptibilities therapeutic stabilization guide forced smaller screening broad creation protein scientific biologics though formulations avenues pharmaceutical platform aggregation tools generation universities consequently treatment specificity stability molecular diseases innovative physicochemical formulation mechanisms types solubility companies industry intensive formed relationship map strategies led excellent edge malignant train faster entrepreneurial cheaper biotechnology databases thereby proteins potency denaturation labour time biophysics designing lay instance biology systematically insurmountable subject larger revolution stage reduce structural few advantages

Project "PIPPI" data sheet

The following table provides information about the project.

Coordinator	DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://www.pippi.kemi.dtu.dk/
Total cost	4˙067˙745 €
EC max contribution	4˙067˙745 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	coordinator	580˙163.00
2	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	747˙649.00
3	NOVOZYMES A/S NOVOZYMES A/S Organization address address: Krogshoejvej 36 city: BAGSVAERD postcode: 2880 website: www.novozymes.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (BAGSVAERD)	participant	580˙163.00
4	MEDIMMUNE LIMITED MEDIMMUNE LIMITED Organization address address: MILSTEIN BUILDING GRANTA PARK city: CAMBRIDGE postcode: CB21 6GH website: http://www.cambridgeantibody.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	546˙575.00
5	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	546˙575.00
6	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	participant	527˙318.00
7	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	290˙081.00
8	WYATT TECHNOLOGY EUROPE GMBH WYATT TECHNOLOGY EUROPE GMBH Organization address address: Hochstrasse 18 city: Dernbach postcode: 56307 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Dernbach)	participant	249˙216.00
9	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: Lund postcode: 22100 website: www.lu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (Lund)	partner	0.00
10	NANOTEMPER TECHNOLOGIES GMBH NANOTEMPER TECHNOLOGIES GMBH Organization address address: FLOSSERGASSE 4 city: MUNCHEN postcode: 81369 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	partner	0.00

Map

Project objective

The revolution of biotechnology has led to the creation of various types of therapeutic biologics with the potential to provide treatment for new chronic and malignant diseases. Though the potential advantages of biologics lay in their high specificity and potency combined with few side effects, their formulation still remains a large challenge to pharmaceutical scientists. This is in part due to the complex, not-well understood relationship between the physicochemical properties of proteins and formulation conditions required for protein stability. A comprehensive understanding of the molecular mechanisms behind protein stabilization and solubility would provide the formulation scientists with knowledge of the interplay between formulation and stability that in turn could potentially make formulation development faster, cheaper and less labour intensive than the currently used broad screening approach. Understanding the susceptibilities of formulations to protein aggregation and denaturation can reduce the response time to for instance product failure. Few universities in Europe have formulation of biologics as a scientific subject. Consequently, the pharmaceutical industry is forced to train scientists - a challenge for larger companies, and an insurmountable task for smaller companies. Scientists in the field of structural biology, biophysics, protein formulation and stability have formed a consortium to systematically map physicochemical properties of biologics, formulation conditions and protein stability. The main objective of the consortium is to provide a new generation of innovative and entrepreneurial early-stage researchers that will develop methodologies, tools and databases to guide the formulation of robust biologics. The consortium will not only provide an excellent platform to train a new generation of formulation scientists, but also establish avenues for designing new formulation strategies and thereby securing the leading edge of EU expertise.

Deliverables

List of deliverables.
Project website	Websites, patent fillings, videos etc.	2019-05-31 18:15:21

Take a look to the deliverables list in detail: detailed list of PIPPI deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Priyanka Singh, Aisling Roche, Christopher F. van der Walle, Shahid Uddin, Jiali Du, Jim Warwicker, Alain Pluen, Robin Curtis Determination of Proteinâ€“Protein Interactions in a Mixture of Two Monoclonal Antibodies published pages: 4775-4786, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.9b00430	Molecular Pharmaceutics 16/12	2020-02-13
2019	Max Hebditch, Aisling Roche, Robin A. Curtis, Jim Warwicker Models for Antibody Behavior in Hydrophobic Interaction Chromatography and in Self-Association published pages: 1434-1441, ISSN: 0022-3549, DOI: 10.1016/j.xphs.2018.11.035	Journal of Pharmaceutical Sciences 108/4	2020-01-30
2019	Matja Zalar, Alexander P. Golovanov New Disulphide Bond in Cystatin-Based Protein Scaffold Prevents Domain-Swap-Mediated Oligomerization and Stabilizes the Functionally Active Form published pages: 18248-18256, ISSN: 2470-1343, DOI: 10.1021/acsomega.9b02269	ACS Omega 4/19	2020-01-30
2019	Lorenzo Gentiluomo, Dierk Roessner, Dillen Augustijn, Hristo Svilenov, Alina Kulakova, Sujata Mahapatra, Gerhard Winter, Werner Streicher, Ã…smund Rinnan, GÃ¼nther H.J. Peters, Pernille Harris, Wolfgang FrieÃŸ Application of interpretable artificial neural networks to early monoclonal antibodies development published pages: 81-89, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2019.05.017	European Journal of Pharmaceutics and Biopharmaceutics 141	2020-01-30
2019	Hristo Svilenov, Gerhard Winter Rapid sample-saving biophysical characterisation and long-term storage stability of liquid interferon alpha2a formulations: Is there a correlation? published pages: 42-50, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2019.03.025	International Journal of Pharmaceutics 562	2020-01-30
2019	A. Kulakova, S. Indrakumar, P. SÃ¸nderby, L. Gentiluomo, W. Streicher, D. Roessner, W. FrieÃŸ, G. H.J. Peters, P. Harris Structural-stability studies on recombinant human transferrin published pages: , ISSN: , DOI: 10.1101/742957	bioRxiv	2020-01-30
2020	Andreas Tosstorff, Tim Menzen, Gerhard Winter Exploring Chemical Space for New Substances to Stabilize a Therapeutic Monoclonal Antibody published pages: 301-307, ISSN: 0022-3549, DOI: 10.1016/j.xphs.2019.10.057	Journal of Pharmaceutical Sciences 109/1	2020-01-30
2020	Alina Kulakova, Sowmya Indrakumar, Pernille SÃ¸nderby, Lorenzo Gentiluomo, Werner Streicher, Dierk Roessner, Wolfgang FrieÃŸ, GÃ¼nther H.J. Peters, Pernille Harris Small angle X-ray scattering and molecular dynamic simulations provide molecular insight for stability of recombinant human transferrin published pages: 100017, ISSN: 2590-1524, DOI: 10.1016/j.yjsbx.2019.100017	Journal of Structural Biology: X 4	2020-01-30
2018	Roberto Fernandez-Alvarez, Å½iga MedoÅ¡, ZdenÄ›k ToÅ¡ner, Alexander Zhigunov, Mariusz Uchman, Stefan HervÃ¸-Hansen, Mikael Lund, Marija BeÅ¡ter-RogaÄ, Pavel MatÄ›jÃÄek Total Description of Intrinsic Amphiphile Aggregation: Calorimetry Study and Molecular Probing published pages: 14448-14457, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b03462	Langmuir 34/47	2020-01-30
2020	Lorenzo Gentiluomo, Dierk Roessner, Werner Streicher, Sujata Mahapatra, Pernille Harris, Wolfgang FrieÃŸ Characterization of Native Reversible Self-Association of a Monoclonal Antibody Mediated by Fab-Fab Interaction published pages: 443-451, ISSN: 0022-3549, DOI: 10.1016/j.xphs.2019.09.021	Journal of Pharmaceutical Sciences 109/1	2020-01-30
2019	Andreas Tosstorff, Hristo Svilenov, GÃ¼nther H.J. Peters, Pernille Harris, Gerhard Winter Structure-based discovery of a new protein-aggregation breaking excipient published pages: 207-216, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2019.09.010	European Journal of Pharmaceutics and Biopharmaceutics 144	2020-01-30
2019	Marcello Martinez Morales, Matja Zalar, Silvia Sonzini, Alexander P. Golovanov, Christopher F. van der Walle, Jeremy P. Derrick Interaction of a Macrocycle with an Aggregation-Prone Region of a Monoclonal Antibody published pages: 3100-3108, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.9b00338	Molecular Pharmaceutics 16/7	2020-01-30
2020	Lorenzo Gentiluomo, Hristo L. Svilenov, Dillen Augustijn, Inas El Bialy, Maria Laura Greco, Alina Kulakova, Sowmya Indrakumar, Sujata Mahapatra, Marcello Martinez Morales, Christin Pohl, Aisling Roche, Andreas Tosstorff, Robin Curtis, Jeremy P. Derrick, Allan NÃ¸rgaard, Tarik A. Khan, GÃ¼nther H. J. Peters, Alain Pluen, Ã…smund Rinnan, Werner W. Streicher, Christopher F. van der Walle, Shahid Uddi Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization published pages: , ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.9b00852	Molecular Pharmaceutics	2020-01-30
2019	Dillen Augustijn, Sujata Mahapatra, Werner Streicher, Hristo Svilenov, Alina Kulakova, Christin Pohl, Ã…smund Rinnan Novel non-linear curve fitting to resolve protein unfolding transitions in intrinsic fluorescence differential scanning fluorimetry published pages: 506-517, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2019.06.001	European Journal of Pharmaceutics and Biopharmaceutics 142	2020-01-30
2019	Lorenzo Gentiluomo, Vanessa Schneider, Dierk Roessner, Wolfgang FrieÃŸ Coupling Multi-Angle Light Scattering to Reverse-Phase Ultra-High-Pressure Chromatography (RP-UPLC-MALS) for the characterization monoclonal antibodies published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-51233-6	Scientific Reports 9/1	2020-01-30
2019	Matja Zalar, Sowmya Indrakumar, Colin W. Levy, Richard B. Tunnicliffe, GÃ¼nther H. J. Peters, Alexander P. Golovanov Studies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-45565-6	Scientific Reports 9/1	2020-01-30
2020	Hristo L. Svilenov, Alina Kulakova, Matja Zalar, Alexander P. Golovanov, Pernille Harris, Gerhard Winter Orthogonal Techniques to Study the Effect of pH, Sucrose, and Arginine Salts on Monoclonal Antibody Physical Stability and Aggregation During Long-Term Storage published pages: 584-594, ISSN: 0022-3549, DOI: 10.1016/j.xphs.2019.10.065	Journal of Pharmaceutical Sciences 109/1	2020-01-30
2019	Silvia Sonzini, Maria Laura Greco, Thais Cailleau, Lauren Adams, Luke Masterson, Balakumar Vijayakrishnan, Conor Barry, Phillip Howard, Peter Ravn, Christopher F. van der Walle Improved Physical Stability of an Antibodyâ€“Drug Conjugate Using Hostâ€“Guest Chemistry published pages: , ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.9b00809	Bioconjugate Chemistry	2020-01-30
2019	Sowmya Indrakumar, Matja Zalar, Christin Pohl, Allan NÃ¸rgaard, Werner Streicher, Pernille Harris, Alexander P. Golovanov, GÃ¼nther H.J. Peters Conformational Stability Study of a Therapeutic Peptide Plectasin Using Molecular Dynamics Simulations in Combination with NMR published pages: 4867-4877, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.9b02370	The Journal of Physical Chemistry B 123/23	2020-01-30
2019	Hristo Svilenov, Gerhard Winter The ReFOLD assay for protein formulation studies and prediction of protein aggregation during long-term storage published pages: 131-139, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2019.02.018	European Journal of Pharmaceutics and Biopharmaceutics 137	2020-01-30
2017	Pernille Harris PIPPI â€“ Protein-excipient Interactions and Protein-Protein Interactions in formulation â€“ ERC published pages: 75-77, ISSN: 2398-7073, DOI: 10.21820/23987073.2017.8.75	Impact 2017/8	2019-07-08
2018	Hristo Svilenov, Lorenzo Gentiluomo, Wolfgang Friess, Dierk Roessner, Gerhard Winter A New Approach to Study the Physical Stability of Monoclonal Antibody Formulationsâ€”Dilution From a Denaturant published pages: 3007-3013, ISSN: 0022-3549, DOI: 10.1016/j.xphs.2018.08.004	Journal of Pharmaceutical Sciences 107/12	2019-02-26

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