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ISPIC SIGNED

Image-Guided Surgery (IGS) and Personalised Postoperative Immunotherapy To Improving Cancer Outcome

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ISPIC project word cloud

Explore the words cloud of the ISPIC project. It provides you a very rough idea of what is the project "ISPIC" about.

disease therapeutic conjunction lifetime relapse limitations inability ultimately reagent monitor personalised treatment therapy curative aggressive directions protection immune basic toxicity initial encapsulate libraries option models gene radiotherapy lack payload efficacy signatures biomolecules multiplexed optimise months multidisciplinary starts resides platforms micrometastases distal identification profiles forms techniques components guided function strategy image intended tumour body implies time visualised accessible surgical biomarkers mass mouse tissues cancer modulating events underlie tumours solid immunotherapeutic radiation observation postoperative interactions implementing resection effectiveness followed latent progression chemotherapy types nanoparticle transgenic combinations accurate encapsulated surgery metastatic immunotherapy platform healthy

Project "ISPIC" data sheet

The following table provides information about the project.

Coordinator	PERCUROS BV Organization address address: PLESMANLAAN 1 city: LEIDEN postcode: 2333 BZ website: www.percuros.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.ispic.eu/
Total cost	3˙922˙309 €
EC max contribution	3˙922˙309 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	PERCUROS BV PERCUROS BV Organization address address: PLESMANLAAN 1 city: LEIDEN postcode: 2333 BZ website: www.percuros.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	coordinator	255˙374.00
2	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	680˙998.00
3	THE UNIVERSITY OF SHEFFIELD THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SHEFFIELD)	participant	546˙575.00
4	HELSE BERGEN HFHAUKELAND UNIVERSITY HOSPITAL HELSE BERGEN HFHAUKELAND UNIVERSITY HOSPITAL Organization address address: JONAS LIES VEI 65 city: BERGEN postcode: 5021 website: http://www.helse-bergen.no/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (BERGEN)	participant	286˙275.00
5	UNIVERSITETET I BERGEN UNIVERSITETET I BERGEN Organization address address: MUSEPLASSEN 1 city: BERGEN postcode: 5020 website: www.uib.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (BERGEN)	participant	286˙275.00
6	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	265˙226.00
7	UNIVERSITA DEGLI STUDI DI CAMERINO UNIVERSITA DEGLI STUDI DI CAMERINO Organization address address: PIAZZA CAVOUR 19F city: CAMERINO postcode: 62032 website: www.unicam.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CAMERINO)	participant	258˙061.00
8	JENACELL GMBH JENACELL GMBH Organization address address: GOSCHWITZER STR. 22 city: JENA postcode: 7745 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (JENA)	participant	249˙216.00
9	MEDRES-MEDICAL RESEARCH GMBH MEDRES-MEDICAL RESEARCH GMBH Organization address address: GLEUELER STRASSE 50 city: KOLN postcode: 50931 website: www.medres.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOLN)	participant	249˙216.00
10	TECOBIOSCIENCES GMBH TECOBIOSCIENCES GMBH Organization address address: HABICHTSTRASSE 21 city: LANDSHUT postcode: 84036 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LANDSHUT)	participant	249˙216.00
11	TECHNISCHE UNIVERSITEIT DELFT TECHNISCHE UNIVERSITEIT DELFT Organization address address: STEVINWEG 1 city: DELFT postcode: 2628 CN website: www.tudelft.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	212˙811.00
12	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	127˙687.00
13	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	127˙687.00
14	UNIVERSITEIT VAN AMSTERDAM UNIVERSITEIT VAN AMSTERDAM Organization address address: SPUI 21 city: AMSTERDAM postcode: 1012WX website: www.uva.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	127˙687.00

Map

Project objective

The basic concept of our proposal is to develop nanoparticle-based encapsulated libraries of different immunotherapeutic biomolecules for treatment after surgery as part of a novel cancer management strategy. The current state-of-art for the management of cancer starts with surgery, after identification of an accessible tumour mass. Surgery remains an effective treatment option for many types of cancer today and it is considered curative treatment for most solid tumours. It forms part of a multidisciplinary approach used in conjunction with radiotherapy or chemotherapy. These approaches, however, have several limitations, including inability of surgical resection to affect distal metastatic disease, toxicity to healthy tissues with chemotherapy and lack of effectiveness of radiation therapy in more aggressive tumours. The observation that cancer can relapse months or years after initial surgery implies that micrometastases still resides within the body in a latent state. Our proposal is to take cancer therapy to beyond state-of-art by implementing techniques which will take us into new directions. This includes a) new methods to identify immune gene profiles and biomarkers b) transgenic mouse models where the complex interactions that underlie immune function can be visualised as multiplexed events in real time and c) the use of nanoparticle-based libraries of immune modulating reagent combinations. There are three key objectives within this project: i) to use immune gene signatures to monitor disease progression and therapeutic efficacy of immunotherapy combinations on nanoparticle-based platforms, ii) to optimise the platform to encapsulate libraries of immune components for more personalised, accurate and timely delivery of the payload to its intended target and iii) to optimise the overall cancer management process of image-guided surgery followed by postoperative immunotherapy so that we can ultimately provide a lifetime of protection against cancer.

Deliverables

List of deliverables.
Project website live	Websites, patent fillings, videos etc.	2020-02-20 16:32:03
All ESRs recruited	Other	2020-02-20 16:32:03

Take a look to the deliverables list in detail: detailed list of ISPIC deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. LÃ¶wik, Ferry Ossendorp, Luis J. Cruz Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles published pages: 6485-6500, ISSN: 1838-7640, DOI: 10.7150/thno.34429	Theranostics 9/22	2020-02-20
2019	Tamim Abdelaal, Vincent van Unen, Thomas HÃ¶llt, Frits Koning, Marcel J.T. Reinders, Ahmed Mahfouz Predicting Cell Populations in Single Cell Mass Cytometry Data published pages: 769-781, ISSN: 1552-4922, DOI: 10.1002/cyto.a.23738	Cytometry Part A 95/7	2020-02-20
2019	Na Li, Vincent van Unen, Nannan Guo, Tamim Abdelaal, Antonios Somarakis, Jeroen Eggermont, Ahmed Mahfouz, Susana M. Chuva de Sousa Lopes, Boudewijn P. F. Lelieveldt, Frits Koning Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01932	Frontiers in Immunology 10	2020-02-20
2018	Di Martino, Piera; Gigliobianco, Maria; Casadidio, Cristina; Censi, Roberta Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability published pages: , ISSN: 1999-4923, DOI: 10.20944/PREPRINTS201807.0233.V1	Pharmaceutics, Vol 10, Iss 3, p 134 (2018) 4	2020-02-20
2018	Mary P. Hall, Carolyn C. Woodroofe, Monika G. Wood, Ivo Que, Moniek vanâ€™t Root, Yanto Ridwan, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Keith V. Wood, Clemens LÃ¶wik, Laura Mezzanotte Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02542-9	Nature Communications 9/1	2020-02-20
2019	Cristina Casadidio, Dolores Vargas Peregrina, Maria Rosa Gigliobianco, Siyuan Deng, Roberta Censi, Piera Di Martino Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science published pages: 369, ISSN: 1660-3397, DOI: 10.3390/md17060369	Marine Drugs 17/6	2020-02-20
2018	Roberta Censi, Dolores Vargas Peregrina, Giovanna Lacava, Dimitrios Agas, Giulio Lupidi, Maria Sabbieti, Piera Di Martino Cosmetic Formulation Based on an AÃ§ai Extract published pages: 48, ISSN: 2079-9284, DOI: 10.3390/cosmetics5030048	Cosmetics 5/3	2020-02-20
2019	Tamim Abdelaal, Lieke Michielsen, Davy Cats, Dylan Hoogduin, Hailiang Mei, Marcel J. T. Reinders, Ahmed Mahfouz A comparison of automatic cell identification methods for single-cell RNA sequencing data published pages: , ISSN: 1474-760X, DOI: 10.1186/s13059-019-1795-z	Genome Biology 20/1	2020-02-20
2019	Michele Genangeli, Annemarie M. M. Heijens, Alice Rustichelli, Noortje Dien Schuit, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Sauro Vittori, Tiffany Porta Siegel, Ron M.A. Heeren MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment published pages: 2041-2050, ISSN: 1044-0305, DOI: 10.1007/s13361-019-02265-9	Journal of The American Society for Mass Spectrometry 30/10	2020-02-20
2019	VinÃcius Barreto Garcia, ThaÃs Gomes de Carvalho, Luiz Henrique da Silva Gasparotto, Heloiza Fernanda Oliveira da Silva, Aurigena Antunes de AraÃºjo, Gerlane Coelho Bernardo Guerra, Timo Schomann, Luis J. Cruz, Alan B. Chan, Raimundo Fernandes de AraÃºjo JÃºnior Environmentally compatible bioconjugated gold nanoparticles as efficient contrast agents for inflammation-induced cancer imaging published pages: , ISSN: 1931-7573, DOI: 10.1186/s11671-019-2986-y	Nanoscale Research Letters 14/1	2020-02-20
2019	Guillaume Beyrend, EsmÃ© van der Gracht, Ayse Yilmaz, Suzanne van Duikeren, Marcel Camps, Thomas HÃ¶llt, Anna Vilanova, Vincent van Unen, Frits Koning, Noel F. C. C. de Miranda, Ramon Arens, Ferry Ossendorp PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors published pages: , ISSN: 2051-1426, DOI: 10.1186/s40425-019-0700-3	Journal for ImmunoTherapy of Cancer 7/1	2020-02-20
2018	Jing Zuo, Dapeng Sun, Langping Tu, Yanni Wu, Yinghui Cao, Bin Xue, Youlin Zhang, Yulei Chang, Xiaomin Liu, Xianggui Kong, Wybren Jan Buma, Evert Jan Meijer, Hong Zhang Precisely Tailoring Upconversion Dynamics via Energy Migration in Core-Shell Nanostructures published pages: 3054-3058, ISSN: 1433-7851, DOI: 10.1002/anie.201711606	Angewandte Chemie International Edition 57/12	2020-02-20
2018	Maxime D. Slooter, Henricus J.M. Handgraaf, Martin C. Boonstra, Lily-Ann van der Velden, Shadhvi S. Bhairosingh, Ivo Que, Lorraine M. de Haan, Stijn Keereweer, Pieter B.A.A. van Driel, Alan Chan, Hisataka Kobayashi, Alexander L. Vahrmeijer, Clemens W.G.M. LÃ¶wik Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase published pages: 1-7, ISSN: 1368-8375, DOI: 10.1016/j.oraloncology.2017.12.006	Oral Oncology 78	2020-02-20
2019	Michele Genangeli, Ron M. A. Heeren, Tiffany Porta Siegel Tissue classification by rapid evaporative ionization mass spectrometry (REIMS): comparison between a diathermic knife and CO2 laser sampling on classification performance published pages: , ISSN: 1618-2642, DOI: 10.1007/s00216-019-02148-8	Analytical and Bioanalytical Chemistry	2020-02-20
2018	Guillaume Beyrend, Koen Stam, Thomas HÃ¶llt, Ferry Ossendorp, Ramon Arens Cytofast: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations published pages: 435-442, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2018.10.004	Computational and Structural Biotechnology Journal 16	2020-02-20
2019	Jan Willem Kleinovink, Laura Mezzanotte, Giorgia Zambito, Marieke F. Fransen, Luis J. Cruz, J. Sjef Verbeek, Alan Chan, Ferry Ossendorp, Clemens LÃ¶wik A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.03097	Frontiers in Immunology 9	2020-02-20
2019	Natasja L de Vries, Vincent van Unen, Marieke E Ijsselsteijn, Tamim Abdelaal, Ruud van der Breggen, Arantza Farina Sarasqueta, Ahmed Mahfouz, Koen C M J Peeters, Thomas HÃ¶llt, Boudewijn P F Lelieveldt, Frits Koning, Noel F C C de Miranda High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity published pages: gutjnl-2019-3186, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2019-318672	Gut	2020-02-20
2019	Roberta Censi, Cristina Casadidio, Alessandra Dubbini, Manuela Cortese, Stefania Scuri, Iolanda Grappasonni, Samuel Golob, Dario Vojnovic, Maria Giovanna Sabbieti, Dimitrios Agas, Piera Di Martino Thermosensitive hybrid hydrogels for the controlled release of bioactive vancomycin in the treatment of orthopaedic implant infections published pages: 322-333, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2019.07.006	European Journal of Pharmaceutics and Biopharmaceutics 142	2020-02-20
2018	Iris N. Pardieck, Guillaume Beyrend, Anke Redeker, Ramon Arens Cytomegalovirus infection and progressive differentiation of effector-memory T cells published pages: 1554, ISSN: 2046-1402, DOI: 10.12688/f1000research.15753.1	F1000Research 7	2020-02-20
2019	Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry published pages: 460622, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2019.460622	Journal of Chromatography A	2020-02-20
2019	Yaima Campos, Amisel Almirall, GastÃ³n Fuentes, Hans L. Bloem, Eric L. Kaijzel, Luis J. Cruz Tissue Engineering: An Alternative to Repair Cartilage published pages: 357-373, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2018.0330	Tissue Engineering Part B: Reviews 25/4	2020-02-20
2017	Jian Yang, Yuxue Liu, Yangyang Zhao, Zheng Gong, Meng Zhang, Duanting Yan, Hancheng Zhu, Chunguang Liu, Changshan Xu, Hong Zhang Ratiometric Afterglow Nanothermometer for Simultaneous in Situ Bioimaging and Local Tissue Temperature Sensing published pages: 8119-8131, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.7b01958	Chemistry of Materials 29/19	2020-02-20
2018	ThaÃs Gomes de Carvalho, VinÃcius Barreto Garcia, Aurigena Antunes de AraÃºjo, Luiz Henrique da Silva Gasparotto, Heloiza Silva, Gerlane Coelho Bernardo Guerra, Emilio de Castro Miguel, Renata Ferreira de Carvalho LeitÃ£o, Deiziane Viana da Silva Costa, Luis J Cruz, Alan B. Chan, Raimundo Fernandes de AraÃºjo JÃºnior Spherical neutral Gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats published pages: , ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2018.06.008	International Journal of Pharmaceutics	2020-02-20
2018	Maria Giovanna Sabbieti, Giovanna Lacava, Andrea Amaroli, Luigi Marchetti, Roberta Censi, Piera Di Martino, Dimitrios Agas Molecular Adjuvants Based on Plasmids Encoding Protein Aggregation Domains Affect Bone Marrow Niche Homeostasis published pages: , ISSN: 1566-5232, DOI: 10.2174/1566523218666180105122626	Current Gene Therapy 17/5	2020-02-20
2018	Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences published pages: 56-66, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.07.011	Journal of Controlled Release 285	2020-02-20
2018	Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch Opportunities of bacterial cellulose to treat epithelial tissues published pages: 808-822, ISSN: 1389-4501, DOI: 10.2174/1389450120666181129092144	Current Drug Targets 20	2020-02-20
2018	Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis Diverse Functions of Macrophages in Different Tumor Microenvironments published pages: 5492-5503, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-18-1367	Cancer Research 78/19	2020-02-20
2019	Na Li, Vincent van Unen, Tamim Abdelaal, Nannan Guo, Sofya A. Kasatskaya, Kristin Ladell, James E. McLaren, Evgeny S. Egorov, Mark Izraelson, Susana M. Chuva de Sousa Lopes, Thomas HÃ¶llt, Olga V Britanova, Jeroen Eggermont, Noel F. C. C. de Miranda, Dmitriy M. Chudakov, David A. Price, Boudewijn P. F. Lelieveldt, Frits Koning Memory CD4+ T cells are generated in the human fetal intestine published pages: , ISSN: 1529-2908, DOI: 10.1038/s41590-018-0294-9	Nature Immunology	2020-02-20

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