Opendata, web and dolomites
p38Cure
New breast cancer therapies based on available p38 MAPK inhibitors
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0p38Cure project word cloud
Explore the words cloud of the p38Cure project. It provides you a very rough idea of what is the project "p38Cure" about.
patients
biology
p38
human
heterogeneity
clinic
clinical
inhibitors
basal
complexity
treatment
surgery
confirmed
radiotherapy
size
divided
grading
er
breast
provides
therapeutic
mapk
her2
trastuzumab
trials
chemotherapy
showing
cancer
inhibition
idea
basic
treat
translating
therapy
agent
cisplatin
drugs
validation
negative
tumor
subtypes
treatments
usually
difficult
benefit
antibody
reduce
combination
luminal
pharmacological
translate
cell
drug
urgent
tumors
vivo
classified
successfully
molecular
triple
therapies
anti
hormonal
genetic
tools
receptor
recapitulate
malignancy
cooperates
patient
xenografts
models
pdx
chemotherapeutic
tend
diagnostic
preclinical
Project "p38Cure" data sheet
The following table provides information about the project.
| Coordinator |
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Total cost | 149˙995 € |
| EC max contribution | 149˙995 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-10-01 to 2017-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) | ES (BARCELONA) | coordinator | 149˙995.00 |
Map
Project objective
Breast tumors are classified by several grading systems and divided into four main molecular subtypes: Luminal A, Luminal B, Triple negative/basal-like and HER2. Since luminal A tumors tend to be ER, their treatment often includes hormonal therapy. HER2 tumors can be treated with Trastuzumab, an anti-Her2 receptor antibody. Hormonal therapies or Trastuzumab cannot be used for triple negative tumors, which are ER- and HER2-, and these are usually treated with a combination of surgery, radiotherapy and chemotherapy. There is an urgent need for new therapies to effectively treat different breast cancer subtypes. Translating basic knowledge on tumor cell biology into more effective diagnostic tools and improved treatments for patients remains difficult. The use of patient-derived xenografts (PDX) as preclinical models that recapitulate the complexity and heterogeneity of the human tumors should help to develop and successfully translate to the clinic new therapies. Our recent work provides genetic and pharmacological evidence showing that p38 MAPK inhibition cooperates with the chemotherapeutic agent cisplatin to reduce breast tumor size and malignancy in vivo. Our results support a potential therapeutic use for p38 MAPK inhibitors in combination with chemotherapeutic drugs. The idea is to use PDX of specific breast cancer subtypes for preclinical validation of a new drug combination therapy with potential benefit to patients, which can be confirmed in clinical trials.
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The information about "P38CURE" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-07-16 9:56:42) correctly updated