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HEPCIR SIGNED

Cell circuits as targets and biomarkers for liver disease and cancer prevention

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

HEPCIR project word cloud

Explore the words cloud of the HEPCIR project. It provides you a very rough idea of what is the project "HEPCIR" about.

pathogenesis global relevance carcinoma therapeutic functional hcc fibrosis health diseases molecular events hepatitis liver risk limited broadly applicable underlying cirrhosis diagnostic cancer cell pan circuits model mechanism investigation virus lacking patients genomics options poor biomarkers despite stage etiology progression cure deterioration prevent carcinogenesis culture prevention animal biology solid disease infection models marked decipher death persists hcv etiologies hepatocellular combined chronic fastest clinical treatment prognosis patient sequence implicated mechanisms rising strategies eliminate reflects alters worldwide uncover data

Project "HEPCIR" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.u1110.inserm.fr/en/content/erc-advanced-grant-hepcir
Total cost	2˙305˙000 €
EC max contribution	2˙305˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-ADG
Funding Scheme	ERC-ADG
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙992˙500.00
2	THE UNIVERSITY OF TEXAS SYSTEM THE UNIVERSITY OF TEXAS SYSTEM Organization address address: COLORADO STREET 601 city: AUSTIN postcode: 78701 2982 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (AUSTIN)	participant	196˙070.00
3	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Organization address address: ONE GUSTAVE L LEVY PLACE BOX 1075 city: NEW YORK postcode: 10029 6574 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	participant	116˙429.00

Map

Project objective

Chronic liver diseases such as liver cirrhosis and hepatocellular carcinoma (HCC) are major challenges for global health. HCC is the second leading and fastest rising cause of cancer death worldwide. The limited availability of therapeutic options reflects our poor understanding of the molecular and clinical mechanisms involved in progression of liver disease. Chronic hepatitis C virus (HCV) infection is a main risk factor for HCC. Although HCC may be avoided by addressing the underlying cause in early stage disease, strategies to prevent HCC in patients with established cirrhosis and advanced fibrosis, in which the risk of HCC persists despite treatment of the underlying cause are lacking. Indeed, even HCV cure does not eliminate the risk of HCC development when advanced fibrosis is already present. Since fibrosis/cirrhosis-driven carcinogenesis is the mechanism of HCC development common to all major etiologies, we propose to use HCV-induced liver disease as a model to decipher the pan-etiology sequence of molecular events underlying disease progression and HCC. Our own data provide solid evidence that HCV infection alters pathways implicated in liver disease progression, including cirrhosis deterioration, HCC development, and overall and liver-specific death. Thus, the molecular investigation of these pathways will identify key cell circuits for the understanding of the pathogenesis of liver disease and HCC in general, and as broadly applicable pan-etiology diagnostic and therapeutic targets. Using a novel patient-derived cell culture model system for liver disease biology combined with advanced functional genomics, novel animal models and clinical investigation, we aim to uncover the cell circuits that are of clinical relevance for liver disease progression and cancer. By providing novel targets and biomarkers for liver disease and HCC prevention, this proposal will have a marked impact on the management and prognosis of patients with liver disease and HCC.

Publications

List of publications.
year	authors and title	journal	last update
2019	Antonio Saviano, Thomas F. Baumert Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease published pages: 307-310, ISSN: 2304-3881, DOI: 10.21037/hbsn.2019.01.21	HepatoBiliary Surgery and Nutrition 8/3	2019-10-17
2018	Steven K. H. Foung, Thomas F. Baumert Editorial: Current Progress and Challenges in the Development of a B Cell Based Hepatitis C Virus Vaccine published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02577	Frontiers in Immunology 9	2019-10-17
2019	Florian Wrensch, Zhen-yong Keck, Steven K.H. Foung, Thomas F. Baumert Learning from a clinical cohort for HCV vaccine development published pages: 9-11, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.03.030	Journal of Hepatology 71/1	2019-10-17
2019	Naoto Fujiwara, Amit G. Singal, Yujin Hoshida Dose and Duration of Aspirin Use to Reduce Incident Hepatocellular Carcinoma published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.30813	Hepatology	2019-10-17
2019	Naoto Fujiwara, Yujin Hoshida Hepatocellular Carcinoma Risk Stratification by Genetic Profiling in Patients with Cirrhosis published pages: 153-162, ISSN: 0272-8087, DOI: 10.1055/s-0039-1681031	Seminars in Liver Disease 39/02	2019-10-17
2019	Ghina Bou About, Emilie Thiebault, Marie Wattenhoferâ€DonzÃ©, Hugues Jacobs, Alain Guimond, Tania Sorg, Eric Robinet, Thomas F. Baumert, Laurent Monassier, Yann Herault Ultrasoundâ€Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma published pages: , ISSN: 2161-2617, DOI: 10.1002/cpmo.62	Current Protocols in Mouse Biology 9/2	2019-10-17
2019	Tongqi Qian, Shijia Zhu, Yujin Hoshida Use of big data in drug development for precision medicine: an update published pages: 189-200, ISSN: 2380-8993, DOI: 10.1080/23808993.2019.1617632	Expert Review of Precision Medicine and Drug Development 4/3	2019-10-17
2019	Atish Mukherji, Shannon M. Bailey, Bart Staels, Thomas F. Baumert The circadian clock and liver function in health and disease published pages: 200-211, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.03.020	Journal of Hepatology 71/1	2019-10-17
2019	Thomas F. Baumert, Yujin Hoshida Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma published pages: 441, ISSN: 1999-4915, DOI: 10.3390/v11050441	Viruses 11/5	2019-10-17
2019	Hagen Schwenzer, Frank JÃ¼hling, Alexander Chu, Laura J. Pallett, Thomas F. Baumert, Mala Maini, Ariberto Fassati Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response published pages: 3416-3428.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.02.077	Cell Reports 26/12	2019-10-17
2019	Katharina Herzog, Simonetta Bandiera, Sophie Pernot, Catherine Fauvelle, Frank JÃ¼hling, AmÃ©lie Weiss, Anne Bull, Sarah C Durand, BÃ©atrice Chane-Woon-Ming, SÃ©bastien Pfeffer, Marion Mercey, HervÃ© Lerat, Jean-Christophe Meunier, Wolfgang Raffelsberger, Laurent Brino, Thomas F Baumert, Mirjam B Zeisel Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity published pages: gutjnl-2018-3174, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-317423	Gut	2019-10-17
2019	Eloi R Verrier, AmÃ©lie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets published pages: gutjnl-2018-3170, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-317065	Gut	2019-10-17
2017	Isabelle Desombere, Ahmed Atef Mesalam, Richard A. Urbanowicz, Freya Van Houtte, Lieven Verhoye, Zhen-Yong Keck, Ali Farhoudi, Koen Vercauteren, Karin E. Weening, Thomas F. Baumert, Arvind H. Patel, Steven K.H. Foung, Jonathan Ball, Geert Leroux-Roels, Philip Meuleman A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo published pages: 53-64, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.10.015	Antiviral Research 148	2019-10-17
2016	Mirjam B. Zeisel, Thomas F. Baumert Hepatitis B virus: is a cure possible? published pages: 1129-1130, ISSN: 1751-2433, DOI: 10.1080/17512433.2016.1206466	Expert Review of Clinical Pharmacology 9/9	2019-10-17
2017	Che C. Colpitts, Thomas F. Baumert SMAD About Hepatitis C Virus Cell Entry andÂ Liver Disease published pages: 21-23, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2016.11.029	Gastroenterology 152/1	2019-10-17
2018	Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis published pages: 953-962, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312270	Gut 67/5	2019-10-17
2017	Nicolas Goossens, C. Billie Bian, Yujin Hoshida Tailored Algorithms for Hepatocellular Carcinoma Surveillance: Is One-Size-Fits-All Strategy Outdated? published pages: 64-71, ISSN: 2195-9595, DOI: 10.1007/s11901-017-0336-z	Current Hepatology Reports 16/1	2019-10-17
2018	Eric TrÃ©po, Nicolas Goossens, Naoto Fujiwara, Won-Min Song, Antonio Colaprico, Astrid Marot, Laurent Spahr, Pieter Demetter, Christine Sempoux, Gene Y. Im, Joan Saldarriaga, Thierry Gustot, Jacques DeviÃ¨re, Swan N. Thung, Charlotte Minsart, Thomas SerstÃ©, Gianluca Bontempi, Karim Abdelrahman, Jean Henrion, Delphine DegrÃ©, Valerio Lucidi, Laura Rubbia-Brandt, Venugopalan D. Nair, Christophe Mor Combination of Gene Expression Signature and Model for End-Stage Liver Disease Score Predicts Survival of Patients WithÂ Severe Alcoholic Hepatitis published pages: 965-975, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2017.10.048	Gastroenterology 154/4	2019-10-17
2016	Eloi Verrier, Che Colpitts, Catherine Schuster, Mirjam Zeisel, Thomas Baumert Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection published pages: 261, ISSN: 1999-4915, DOI: 10.3390/v8090261	Viruses 8/9	2019-10-17
2017	Daniel F. Hicks, Nicolas Goossens, Ana Blas-GarcÃa, Takuma Tsuchida, Benjamin Wooden, Michael C. Wallace, Natalia Nieto, Abigale Lade, Benjamin Redhead, Arthur I Cederbaum, Joel T. Dudley, Bryan C. Fuchs, Youngmin A. Lee, Yujin Hoshida, Scott L. Friedman Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells published pages: 42563, ISSN: 2045-2322, DOI: 10.1038/srep42563	Scientific Reports 7	2019-10-17
2018	Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger Viral manipulation of STAT3: Evade, exploit, and injure published pages: e1006839, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006839	PLOS Pathogens 14/3	2019-10-17
2017	Emilie Crouchet, Mathieu LefÃ¨vre, Eloi R Verrier, Marine A Oudot, Thomas F Baumert, Catherine Schuster Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux published pages: 896-907, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2015-311289	Gut 66/5	2019-10-17
2016	Eloi R. Verrier, Che C. Colpitts, Camille Sureau, Thomas F. Baumert Hepatitis B virus receptors and molecular drug targets published pages: 567-573, ISSN: 1936-0533, DOI: 10.1007/s12072-016-9718-5	Hepatology International 10/4	2019-10-17
2017	Takaaki Higashi, Scott L. Friedman, Yujin Hoshida Hepatic stellate cells as key target in liver fibrosis published pages: , ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.05.007	Advanced Drug Delivery Reviews	2019-10-17
2018	Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert Hepatitis C Virus (HCV)â€“Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01436	Frontiers in Immunology 9	2019-10-17
2017	Benjamin Wooden, Nicolas Goossens, Yujin Hoshida, Scott L. Friedman Using Big Data to Discover Diagnostics and Therapeutics forÂ Gastrointestinal and Liver Diseases published pages: 53-67.e3, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2016.09.065	Gastroenterology 152/1	2019-10-17
2016	Huagang Lu, John Rogowskyj, Wenquan Yu, Anu Venkatesh, Noshena Khan, Shigeki Nakagawa, Nicolas Goossens, Anna P. Koh, Takaaki Higashi, Ganesh Gunasekaran, Myron E. Schwarz, Spiros P. Hiotis, Xiaodong Xu, William Kinney, Yujin Hoshida, Timothy Block, Andrea Cuconati, Yanming Du Novel substituted aminothiazoles as potent and selective anti-hepatocellular carcinoma agents published pages: 5819-5824, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.10.015	Bioorganic & Medicinal Chemistry Letters 26/23	2019-10-17
2016	Isabelle Desombere, Samira Fafi-Kremer, Freya Van Houtte, Patrick Pessaux, Ali Farhoudi, Laura Heydmann, Lieven Verhoye, Sarah Cole, Jane A. McKeating, Geert Leroux-Roels, Thomas F. Baumert, Arvind H. Patel, Philip Meuleman Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge published pages: 1120-1134, ISSN: 0270-9139, DOI: 10.1002/hep.28428	Hepatology 63/4	2019-10-17
2016	Che C. Colpitts, Joachim Lupberger, Thomas F. Baumert Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis published pages: 7298-7300, ISSN: 0027-8424, DOI: 10.1073/pnas.1607732113	Proceedings of the National Academy of Sciences 113/27	2019-10-17
2017	Thomas F. Baumert, Frank JÃ¼hling, Atsushi Ono, Yujin Hoshida Hepatitis C-related hepatocellular carcinoma in the era of new generation antivirals published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-017-0815-7	BMC Medicine 15/1	2019-10-17
2017	Tanvi Khera, Daniel Todt, Koen Vercauteren, C. Patrick McClure, Lieven Verhoye, Ali Farhoudi, Sabin Bhuju, Robert Geffers, Thomas F. Baumert, Eike Steinmann, Philip Meuleman, Thomas Pietschmann, Richard J.P. Brown Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy published pages: 129-137, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.01.001	Antiviral Research 139	2019-10-17
2016	Simonetta Bandiera, Sophie Pernot, Hussein El Saghire, Sarah C. Durand, Christine Thumann, Emilie Crouchet, Tao Ye, Isabel Fofana, Marine A. Oudot, Jochen Barths, Catherine Schuster, Patrick Pessaux, Markus H. Heim, Thomas F. Baumert, Mirjam B. Zeisel Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis published pages: 6387-6400, ISSN: 0022-538X, DOI: 10.1128/JVI.00619-16	Journal of Virology 90/14	2019-10-17
2018	Daniel J. Felmlee, Dominic GrÃ¼n, Thomas F. Baumert Zooming in on liver zonation published pages: 784-787, ISSN: 0270-9139, DOI: 10.1002/hep.29554	Hepatology 67/2	2019-10-17
2016	Daniel J Felmlee, Audrey Coilly, Raymond T Chung, Didier Samuel, Thomas F Baumert New perspectives for preventing hepatitis C virus liver graft infection published pages: 735-745, ISSN: 1473-3099, DOI: 10.1016/S1473-3099(16)00120-1	The Lancet Infectious Diseases 16/6	2019-10-17
2017	Stefanie J. Hectors, Mathilde Wagner, Octavia Bane, Cecilia Besa, Sara Lewis, Romain Remark, Nelson Chen, M. Isabel Fiel, Hongfa Zhu, Sacha Gnjatic, Miriam Merad, Yujin Hoshida, Bachir Taouli Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-02706-z	Scientific Reports 7/1	2019-10-17
2017	Derek J. Erstad, Andrew M. Tager, Yujin Hoshida, Bryan C. Fuchs The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer published pages: e1311827, ISSN: 2372-3556, DOI: 10.1080/23723556.2017.1311827	Molecular & Cellular Oncology 4/3	2019-10-17
2016	Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma published pages: 99-105, ISSN: 1879-6257, DOI: 10.1016/j.coviro.2016.09.010	Current Opinion in Virology 20	2019-10-17
2018	Hadassa Hirschfield, C Billie Bian, Takaaki Higashi, Shigeki Nakagawa, Tizita Z Zeleke, Venugopalan D Nair, Bryan C Fuchs, Yujin Hoshida In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment published pages: e419, ISSN: 2092-6413, DOI: 10.1038/emm.2017.164	Experimental & Molecular Medicine 50/1	2019-10-17
2016	Rajiv G. Tawar, Laura Heydmann, Charlotte Bach, JÃ¶rg SchÃ¼ttrumpf, Shailesh Chavan, Barnabas J. King, C. Patrick McClure, Jonathan K. Ball, Patrick Pessaux, FranÃ§ois Habersetzer, Ralf Bartenschlager, Mirjam B. Zeisel, Thomas F. Baumert Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin published pages: 1495-1506, ISSN: 0270-9139, DOI: 10.1002/hep.28767	Hepatology 64/5	2019-10-17
2017	Che C. Colpitts, Thomas F. Baumert Claudins in viral infection: from entry to spread published pages: 27-34, ISSN: 0031-6768, DOI: 10.1007/s00424-016-1908-4	PflÃ¼gers Archiv - European Journal of Physiology 469/1	2019-10-17
2017	Che C. Colpitts, Thomas F. Baumert SCARB1 variants and HCV infection: Host susceptibility is lost in translation published pages: 211-213, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.04.013	Journal of Hepatology 67/2	2019-10-17
2017	Che C. Colpitts, Raymond T. Chung, Thomas F. Baumert Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation published pages: 620-623, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.7b00091	ACS Infectious Diseases 3/9	2019-10-17
2017	David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, JÃ¶rg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8 + T Cells in Chronic versus Acute Infection published pages: 648-663.e8, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.09.006	Immunity 47/4	2019-10-17
2017	Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert Advancing hepatitis B virus entry inhibitors published pages: 677-679, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2016.11.028	Journal of Hepatology 66/4	2019-10-17
2017	Zhirong Zhang, GergÃ¶ Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig GÃ¡mez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, BÃ©nÃ©dicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F. Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci Protein kinase D at the Golgi controls NLRP3 inflammasome activation published pages: 2671-2693, ISSN: 0022-1007, DOI: 10.1084/jem.20162040	The Journal of Experimental Medicine 214/9	2019-10-17
2018	Eloi R. Verrier, Seung-Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon-Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert Hepatitis B virus evasion from cyclic guanosine monophosphate-adenosine monophosphate synthase sensing in human hepatocytes published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.30054	Hepatology	2019-10-17
2018	Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling published pages: 32118-4, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.05.033	Journal of Hepatology S0168-8278(18)	2019-10-17
2017	Atsushi Ono, Nicolas Goossens, Richard S Finn, Warren N Schmidt, Swan N Thung, Gene Y Im, Yujin Hoshida Persisting risk of hepatocellular carcinoma after HCV cure monitored by a liver transcriptome signature published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.29203	Hepatology	2019-10-17
2016	Shigeki Nakagawa, Lan Wei, Won Min Song, Takaaki Higashi, Sarani Ghoshal, Rosa S. Kim, C. Billie Bian, Suguru Yamada, Xiaochen Sun, Anu Venkatesh, Nicolas Goossens, Gretchen Bain, Gregory Y. Lauwers, Anna P. Koh, Mohamed El-Abtah, Noor B. Ahmad, Hiroki Hoshida, Derek J. Erstad, Ganesh Gunasekaran, Youngmin Lee, Ming-Lung Yu, Wan-Long Chuang, Chia-Yen Dai, Masahiro Kobayashi, Hiromitsu Kumada, Toru Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition published pages: 879-890, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2016.11.004	Cancer Cell 30/6	2019-10-17
2018	Naoto Fujiwara, Scott L. Friedman, Nicolas Goossens, Yujin Hoshida Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine published pages: 526-549, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.09.016	Journal of Hepatology 68/3	2019-10-17
2017	Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert Toward novel immunocompetent animal models for hepatitis B virus infection published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.29249	Hepatology	2019-10-17
2017	Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape published pages: gutjnl-2016-3125, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312577	Gut	2019-10-17
2016	Simonetta Bandiera, Thomas F. Baumert, Mirjam B. Zeisel Circulating microRNAs for early detection of hepatitis B-related hepatocellular carcinoma published pages: 198-200, ISSN: 2304-3881, DOI: 10.21037/hbsn.2016.03.08	HepatoBiliary Surgery and Nutrition 5/3	2019-10-17
2016	Catherine Fauvelle, Che C. Colpitts, Zhen-yong Keck, Brian G. Pierce, Steven K. H. Foung, Thomas F. Baumert Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies published pages: 1535-1544, ISSN: 1476-0584, DOI: 10.1080/14760584.2016.1194759	Expert Review of Vaccines 15/12	2019-10-17
2016	Mirjam B. Zeisel, Thomas F. Baumert Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma published pages: 671-674, ISSN: 0270-9139, DOI: 10.1002/hep.28653	Hepatology 64/2	2019-10-17
2017	Emilie Crouchet, Thomas F. Baumert, Catherine Schuster Hepatitis C virusâ€“apolipoprotein interactions: molecular mechanisms and clinical impact published pages: 593-606, ISSN: 1478-9450, DOI: 10.1080/14789450.2017.1344102	Expert Review of Proteomics 14/7	2019-10-17
2018	Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert Host-targeting therapies for hepatitis C virus infection: current developments and future applications published pages: 175628481875948, ISSN: 1756-2848, DOI: 10.1177/1756284818759483	Therapeutic Advances in Gastroenterology 11	2019-10-17
2017	Giulia Manzoni, Carine Marinach, Selma TopÃ§u, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-FranÃ§ois Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, FranÃ§ois Nosten, Thomas F Baumert, Olivier Silvie Plasmodium P36 determines host cell receptor usage during sporozoite invasion published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.25903	eLife 6	2019-10-17
2016	Tao Wu, Emilie Heuillard, VÃ©ronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, EugÃ©nie Dalimier, Francine GossÃ©, Gael FourÃ©, Franck Blindauer, CÃ©line Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux, Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice published pages: , ISSN: 2045-2322, DOI: 10.1038/srep35230	Scientific Reports 6/1	2019-10-17
2016	EloiÂ R. Verrier, CheÂ C. Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, RaphaÃ«l Gaudin, Camille Sureau, FranÃ§ois-LoÃ¯c Cosset, JaneÂ A. McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, MirjamÂ B. Zeisel, ThomasÂ F. Baumert Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes published pages: 1357-1368, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.09.084	Cell Reports 17/5	2019-10-17
2018	Mei-Le Keck, Florian Wrensch, Brian G. Pierce, Thomas F. Baumert, Steven K. H. Foung Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01194	Frontiers in Immunology 9	2019-10-17
2017	Nicolas Goossens, Amit G Singal, Lindsay Y King, Karin L Andersson, Bryan C Fuchs, Cecilia Besa, Bachir Taouli, Raymond T Chung, Yujin Hoshida Cost-Effectiveness of Risk Scoreâ€“Stratified Hepatocellular Carcinoma Screening in Patients with Cirrhosis published pages: e101, ISSN: 2155-384X, DOI: 10.1038/ctg.2017.26	Clinical and Translational Gastroenterology 8/6	2019-10-17
2018	Youngmin A. Lee, Luke A. Noon, Kemal M. Akat, Maria D. Ybanez, Ting-Fang Lee, Marie-Luise Berres, Naoto Fujiwara, Nicolas Goossens, Hsin-I Chou, Fatemeh P. Parvin-Nejad, Bilon Khambu, Elisabeth G. M. Kramer, Ronald Gordon, Cathie Pfleger, Doris Germain, Gareth R. John, Kirk N. Campbell, Zhenyu Yue, Xiao-Ming Yin, Ana Maria Cuervo, Mark J. Czaja, M. Isabel Fiel, Yujin Hoshida, Scott L. Friedman Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07338-z	Nature Communications 9/1	2019-10-17
2018	Shijia Zhu, Yujin Hoshida Molecular heterogeneity in hepatocellular carcinoma published pages: HEP10, ISSN: 2045-0923, DOI: 10.2217/hep-2018-0005	Hepatic Oncology 5/1	2019-10-17
2018	Takuma Tsuchida, Youngmin A. Lee, Naoto Fujiwara, Maria Ybanez, Brittany Allen, Sebastiao Martins, M. Isabel Fiel, Nicolas Goossens, Hsin-I. Chou, Yujin Hoshida, Scott L. Friedman A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer published pages: 385-395, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.03.011	Journal of Hepatology 69/2	2019-10-17
2018	James S.V. Lally, Sarani Ghoshal, Danielle K. DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J. Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P. Houde, Alexander E. Anagnostopoulos, Alice Wang, Lindsay A. Broadfield, Rebecca J. Ford, Robert A. Foster, Jamie Bates, Hailing Sun, Ting Wang, Henry Liu, Adrian S. Ray, Asish K. Saha, Jeremy Greenwood, Sathesh Bhat, Geraldine Harriman, Wenyan Miao, Jennifer L. Rocnik, William F. Westlin, Paola Muti, Theodoros Tsakiridis, H. James Harwood, Rosana Kapeller, Yujin Hoshida, Kenneth K. Tanabe, Gregory R. Steinberg, Bryan C. Fuchs Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma published pages: , ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.08.020	Cell Metabolism	2019-10-17
2018	Alessia VirzÃ¬, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger Oncogenic Signaling Induced by HCV Infection published pages: 538, ISSN: 1999-4915, DOI: 10.3390/v10100538	Viruses 10/10	2019-10-17
2018	Sai Krishna Athuluri-Divakar, Yujin Hoshida Generic chemoprevention of hepatocellular carcinoma published pages: , ISSN: 0077-8923, DOI: 10.1111/nyas.13971	Annals of the New York Academy of Sciences	2019-10-17
2018	Carla Eller, Laura Heydmann, Che C. Colpitts, Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses published pages: 3895-3905, ISSN: 1420-682X, DOI: 10.1007/s00018-018-2892-y	Cellular and Molecular Life Sciences 75/21	2019-10-17
2018	Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert Tight junction proteins in gastrointestinal and liver disease published pages: gutjnl-2018-3169, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-316906	Gut	2019-10-17
2018	Thomas F. Baumert, Thomas Berg, Joseph K. Lim, David R. Nelson Status of Direct-acting Antiviral Therapy for HCV Infection and Remaining Challenges published pages: , ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.10.024	Gastroenterology	2019-10-17
2017	Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M. Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M. Llovet Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results published pages: 4472-4481, ISSN: 0938-7994, DOI: 10.1007/s00330-017-4844-6	European Radiology 27/11	2019-10-17
2019	Cheng Li, Yang Wang, Tiantian Liu, Matthias Niklasch, Ke Qiao, Sarah Durand, Li Chen, Mifang Liang, Thomas F. Baumert, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion published pages: 118-129, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.12.019	Antiviral Research 162	2019-10-17
2019	Florian Wrensch, GaÃ«tan Ligat, Laura Heydmann, Catherine Schuster, Mirjam B. Zeisel, Patrick Pessaux, FranÃ§ois Habersetzer, Barnabas J. King, Alexander W. Tarr, Jonathan K. Ball, Michael Winkler, Stefan PÃ¶hlmann, Zhenâ€yong Keck, Steven K.H. Foung, Thomas F. Baumert IFITM s mediate viral evasion in acute and chronic hepatitis C virus infection published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.30699	Hepatology	2019-10-17
2019	Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B. Zeisel, Patrick Pessaux, Zhen-yong Keck, Catherine Schuster, Thomas R. Fuerst, Steven K.H. Foung, Thomas F. Baumert In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection published pages: 136-141, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.12.018	Antiviral Research 162	2019-10-17
2019	Nourdine Hamdane, Frank JÃ¼hling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A. Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, FranÃ§ois Habersetzer, Michel DoffoÃ«l, Tullio Piardi, Daniele So HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response published pages: 2313-2329.e7, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2019.02.038	Gastroenterology 156/8	2019-10-17
2019	Joachim Lupberger, Tom Croonenborghs, Armando Andres Roca Suarez, Nicolaas Van Renne, Frank JÃ¼hling, Marine A. Oudot, Alessia VirzÃ¬, Simonetta Bandiera, Carole Jamey, GergÃ¶ Meszaros, Daniel Brumaru, Atish Mukherji, Sarah C. Durand, Laura Heydmann, Eloi R. Verrier, Hussein El Saghire, Nourdine Hamdane, Ralf Bartenschlager, Shaunt Fereshetian, Evelyn Ramberger, Rileen Sinha, Mohsen Nabian, Celine Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virusâ€“Infected Cells and Liver to Identify Pathways Associated With Disease Development published pages: 537-551.e9, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2019.04.003	Gastroenterology 157/2	2019-10-17

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HEPCIR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HEPCIR" are provided by the European Opendata Portal: CORDIS opendata.