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NEURIMMUNE SIGNED

Neural regulation of immunity

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NEURIMMUNE project word cloud

Explore the words cloud of the NEURIMMUNE project. It provides you a very rough idea of what is the project "NEURIMMUNE" about.

question release involve damage vaccination locally nervous implications insights noxious exacerbated tissues signals injury protective living acute defence skin modulate stimulation complementary genetic survival host wild avenues systemic adaptive innate deficits convey interdisciplinary intradermal paradigm local sensory functions perceived prophylactic pain signs tackle immunity tissue pathogens environmental nociceptive mechanisms neurimmune organisms therapies designed selective functional mouse innervation instructs demonstrated independent depends vaccine sensitivity animals bases inflammation immune damaging innovative nociceptors deficient interactions modulation infections preliminary anatomical brain bidirectional mediators decipher molecular cellular models vaccines capacity regulatory neurons

Project "NEURIMMUNE" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	2˙000˙000 €
EC max contribution	2˙000˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	2˙000˙000.00

Map

Project objective

Survival of living organisms depends on their capacity to develop defence mechanisms against environmental challenges that cause tissue damage and infections. These protective functions involve the nervous system and the immune system, two systems traditionally considered as independent. However anatomical and cellular bases for bidirectional interactions between them have been established and a new paradigm on a regulatory role of the nervous system on immune functions is emerging. Pain is one of the major signs of inflammation. Upon acute injury, inflammation or infections noxious signals are perceived by nociceptors present in tissues, such as the skin. These sensory neurons convey the damaging information to the brain and release a number of mediators locally that could modulate immunity. The goal of this project is to decipher the functional role of sensory neurons and pain sensitivity on immune responses. We will tackle this highly challenging question by studying the immune responses to vaccination in genetic mouse models in which skin innervation by nociceptors is deficient. Our preliminary results are very promising as we already demonstrated that deficits in sensory skin innervation affect both the innate and adaptive immune responses to intradermal vaccine. We will further study the cellular and molecular mechanisms involved in this local and systemic modulation of the immune response by the nervous system. As a complementary approach, we will address the role of an exacerbated pain response on immunity through the selective stimulation of nociceptive neurons in wild type animals. This interdisciplinary study is designed to provide new insights into how the nervous system instructs the immune system. Results from NEURIMMUNE are expected to open new avenues of research on the integrated host response to pathogens with important implications for the design of innovative prophylactic vaccines and therapies.

Publications

List of publications.
year	authors and title	journal	last update
2017	Linda Quatrini, Elisabeth Wieduwild, Sophie Guia, Claire Bernat, Nicolas Glaichenhaus, Eric Vivier, Sophie Ugolini Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells published pages: 3531-3541, ISSN: 0022-1007, DOI: 10.1084/jem.20171048	The Journal of Experimental Medicine 214/12	2019-06-07

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