ObesityDevelop SIGNED
Effects of maternal gestational adiposity on fetal development and perinatal, postnatal and next generation health.
Total Cost €
0EC-Contrib. €
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Project "ObesityDevelop" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITY OF BRISTOL
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙863˙321 € |
| EC max contribution | 1˙863˙321 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-ADG |
| Funding Scheme | ERC-ADG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-11-01 to 2020-10-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITY OF BRISTOL | UK (BRISTOL) | coordinator | 1˙863˙321.00 |
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Project objective
Pregnant women who are overweight/obese have increased risks of adverse perinatal outcomes, and of having offspring who are subsequently overweight/obese. A potentially important consequence of this is that it will drive the obesity epidemic across generations. Evidence from animal models supports this, but it has not been explored in humans. Furthermore, we need to know the mechanisms linking maternal adiposity to adverse offspring and next generation outcomes in order to develop preventive interventions. I will use data from up to 100,000 participants from nine cohorts and two consortia to determine the effects of maternal pregnancy levels of adiposity and associated circulating nutrients on levels of adiposity and cardiometabolic health at three periods of the lifecourse: (i) fetal development, (ii) infancy to adulthood and (iii) in the next generation. My team is world leading in this area, and we will use state-of-the-art methods to advance the field by: (i) assessing a larger number of maternal nutrients than previously; (ii) accurately assessing maternal gestational fat deposition; (iii) determining the effects of maternal exposures on fetal fat and lean mass, and metabolic response; and (iv) measuring outcomes into the next generation. Effects will be replicated in several independent cohorts and triangulated across different state-of-the-art statistical methods: (i) cross-cohort comparisons between European and low and middle income country cohorts, in which confounding structures differ; (ii) comparisons of associations of maternal exposures to equivalent associations of paternal exposures, under the assumption that intrauterine effects are maternal specific; and (iii) Mendelian randomization using genetic variants as unconfounded proxies for maternal exposures. My proposed research is important because of how many women start pregnancy overweight/obese. It will provide a step-change in knowledge of how to prevent adverse outcomes across generations.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Neil Pearce, Debbie A Lawlor Causal inference—so much more than statistics published pages: 1895-1903, ISSN: 0300-5771, DOI: 10.1093/ije/dyw328 |
International Journal of Epidemiology 45/6 | 2019-10-08 |
| 2018 |
Judith S. Brand, Jane West, Derek Tuffnell, Philippa K. Bird, John Wright, Kate Tilling, Debbie A. Lawlor Gestational diabetes and ultrasound-assessed fetal growth in South Asian and White European women: findings from a prospective pregnancy cohort published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-018-1191-7 |
BMC Medicine 16/1 | 2019-10-08 |
| 2019 |
Philippa K Bird, Rosemary R. C. McEachan, Mark Mon-Williams, Neil Small, Jane West, Peter Whincup, John Wright, Elizabeth Andrews, Sally E Barber, Liam J B Hill, Laura Lennon, Dan Mason, Katy A Shire, Dagmar Waiblinger, Amanda H. Waterman, Deborah A. Lawlor, Kate E. Pickett Growing up in Bradford: protocol for the age 7–11 follow up of the Born in Bradford birth cohort published pages: , ISSN: 1471-2458, DOI: 10.1186/s12889-019-7222-2 |
BMC Public Health 19/1 | 2019-09-20 |
| 2019 |
Christel M. Middeldorp, Janine F. Felix, Anubha Mahajan, Mark I. McCarthy The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects published pages: 279-300, ISSN: 0393-2990, DOI: 10.1007/s10654-019-00502-9 |
European Journal of Epidemiology 34/3 | 2019-09-20 |
| 2017 |
Ralph McGinnis, Valgerdur Steinthorsdottir, Nicholas O Williams, Gudmar Thorleifsson, Scott Shooter, Sigrun Hjartardottir, Suzannah Bumpstead, Lilja Stefansdottir, Lucy Hildyard, Jon K Sigurdsson, John P Kemp, Gabriela B Silva, Liv Cecilie V Thomsen, Tiina Jääskeläinen, Eero Kajantie, Sally Chappell, Noor Kalsheker, Ashley Moffett, Susan Hiby, Wai Kwong Lee, Sandosh Padmanabhan, Nigel A B Simps Variants in the fetal genome near FLT1 are associated with risk of preeclampsia published pages: 1255-1260, ISSN: 1061-4036, DOI: 10.1038/ng.3895 |
Nature Genetics 49/8 | 2019-07-04 |
| 2017 |
N Patel, K M Godfrey, D Pasupathy, J Levin, A C Flynn, L Hayes, A L Briley, R Bell, D A Lawlor, E Oteng-Ntim, S M Nelson, S C Robson, N Sattar, C Singh, J Wardle, S L White, P T Seed, L Poston Infant adiposity following a randomised controlled trial of a behavioural intervention in obese pregnancy published pages: , ISSN: 0307-0565, DOI: 10.1038/ijo.2017.44 |
International Journal of Obesity | 2019-07-04 |
| 2018 |
Robin N Beaumont, Nicole M Warrington, Alana Cavadino, Jessica Tyrrell, Michael Nodzenski, Momoko Horikoshi, Frank Geller, Ronny Myhre, Rebecca C Richmond, Lavinia Paternoster, Jonathan P Bradfield, Eskil Kreiner-Møller, Ville Huikari, Sarah Metrustry, Kathryn L Lunetta, Jodie N Painter, Jouke-Jan Hottenga, Catherine Allard, Sheila J Barton, Ana Espinosa, Julie A Marsh, Catherine Potter, Ge Zhang Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics published pages: 742-756, ISSN: 0964-6906, DOI: 10.1093/hmg/ddx429 |
Human Molecular Genetics 27/4 | 2019-07-04 |
| 2017 |
N M Warrington, R Richmond, B Fenstra, R Myhre, R Gaillard, L Paternoster, C A Wang, R N Beaumont, S Das, M Murcia, S J Barton, A Espinosa, E Thiering, M Atalay, N Pitkänen, I Ntalla, A E Jonsson, R Freathy, V Karhunen, C M T Tiesler, C Allard, A Crawford, S M Ring, M Melbye, P Magnus, F Rivadeneira, L Skotte, T Hansen, J Marsh, M Guxens, J W Holloway, H Grallert, V W V Jaddoe, W L Lowe Jr, T Rou Maternal and fetal genetic contribution to gestational weight gain published pages: 775-784, ISSN: 0307-0565, DOI: 10.1038/ijo.2017.248 |
International Journal of Obesity 42/4 | 2019-07-04 |
| 2017 |
Debbie A. Lawlor, Kate Tilling, George Davey Smith Triangulation in aetiological epidemiology published pages: dyw314, ISSN: 0300-5771, DOI: 10.1093/ije/dyw314 |
International Journal of Epidemiology | 2019-07-04 |
| 2016 |
Jessica Tyrrell, Rebecca C. Richmond, Tom M. Palmer, Bjarke Feenstra, Janani Rangarajan, Sarah Metrustry, Alana Cavadino, Lavinia Paternoster, Loren L. Armstrong, N. Maneka G. De Silva, Andrew R. Wood, Momoko Horikoshi, Frank Geller, Ronny Myhre, Jonathan P. Bradfield, Eskil Kreiner-Møller, Ville Huikari, Jodie N. Painter, Jouke-Jan Hottenga, Catherine Allard, Diane J. Berry, Luigi Bouchard, Shik Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight published pages: 1129, ISSN: 0098-7484, DOI: 10.1001/jama.2016.1975 |
JAMA 315/11 | 2019-07-04 |
| 2016 |
Qin Wang, Peter Würtz, Kirsi Auro, Laure Morin-Papunen, Antti J Kangas, Pasi Soininen, Mika Tiainen, Tuulia Tynkkynen, Anni Joensuu, Aki S Havulinna, Kristiina Aalto, Marko Salmi, Stefan Blankenberg, Tanja Zeller, Jorma Viikari, Mika Kähönen, Terho Lehtimäki, Veikko Salomaa, Sirpa Jalkanen, Marjo-Riitta Järvelin, Markus Perola, Olli T Raitakari, Debbie A Lawlor, Johannes Kettunen, Mika Ala-Ko Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence published pages: 1445-1457, ISSN: 0300-5771, DOI: 10.1093/ije/dyw147 |
International Journal of Epidemiology 45/5 | 2019-07-04 |
| 2013 |
Deborah Lawlor, Rebecca Richmond, Nicole Warrington, George McMahon, George Davey Smith, Jack Bowden, David M Evans Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them published pages: 11, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.10567.1 |
Wellcome Open Research 2 | 2019-07-04 |
| 2016 |
Wang Q, Würtz P, Auro K, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Jokelainen J, Santalahti K, Salmi M, Blankenberg S, Zeller T, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Perola M, Jalkanen S, Järvelin M-R, Raitakari OT, Kettunen J, Lawlor DA*, Ala-Korpela M* (*equal senior authors) Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence published pages: 205, ISSN: 1741-7015, DOI: 10.1186/s12916-016-0733-0 |
BMC Medicine 2016 | 2019-07-04 |
| 2016 |
Peter Würtz, Qin Wang, Marjo Niironen, Tuulia Tynkkynen, Mika Tiainen, Fotios Drenos, Antti J Kangas, Pasi Soininen, Michael R Skilton, Kauko Heikkilä, Anneli Pouta, Mika Kähönen, Terho Lehtimäki, Richard J Rose, Eero Kajantie, Markus Perola, Jaakko Kaprio, Johan G Eriksson, Olli T Raitakari, Debbie A Lawlor, George Davey Smith, Marjo-Riitta Järvelin, Mika Ala-Korpela, Kirsi Auro Metabolic signatures of birthweight in 18 288 adolescents and adults published pages: 1539-1550, ISSN: 0300-5771, DOI: 10.1093/ije/dyw255 |
International Journal of Epidemiology 45/5 | 2019-07-04 |
| 2017 |
Diana L. Santos Ferreira, Dylan M. Williams, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, George Davey Smith, Marjo-Riitta Jarvelin, Debbie A. Lawlor Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohorts published pages: e1002376, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1002376 |
PLOS Medicine 14/8 | 2019-07-04 |
| 2017 |
Matias C. Vieira, Sara L. White, Nashita Patel, Paul T. Seed, Annette L. Briley, Jane Sandall, Paul Welsh, Naveed Sattar, Scott M. Nelson, Debbie A. Lawlor, Lucilla Poston, Dharmintra Pasupathy Prediction of uncomplicated pregnancies in obese women: a prospective multicentre study published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-017-0956-8 |
BMC Medicine 15/1 | 2019-07-04 |
| 2017 |
Richmond RC, Timpson NJ, Felix JF, Palmer T, Gaillard R, McMahon G, Davey Smith G, Jaddoe VW, Lawlor DA Using genetic variation to explore the causal effect of maternal pregnancy adiposity on future offspring adiposity published pages: e1002221, ISSN: 1549-1277, DOI: 10.1371/journal.pmed.1002221 |
PloS Medicine 2017 | 2019-07-04 |
| 2018 |
Jane West, Gillian Santorelli, Peter H. Whincup, Lesley Smith, Naveed A. Sattar, Noel Cameron, Diane Farrar, Paul Collings, John Wright, Debbie A. Lawlor Association of maternal exposures with adiposity at age 4/5Â years in white British and Pakistani children: findings from the Born in Bradford study published pages: 242-252, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4457-2 |
Diabetologia 61/1 | 2019-07-04 |
| 2016 |
Diane Farrar, Mark Simmonds, Maria Bryant, Trevor A Sheldon, Derek Tuffnell, Su Golder, Fidelma Dunne, Debbie A Lawlor Hyperglycaemia and risk of adverse perinatal outcomes: systematic review and meta-analysis published pages: i4694, ISSN: 1756-1833, DOI: 10.1136/bmj.i4694 |
BMJ | 2019-07-04 |
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