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RESSTORE

REgenerative Stem cell therapy for STroke in Europe

Total Cost €

0

EC-Contrib. €

0

Partnership

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 RESSTORE project word cloud

Explore the words cloud of the RESSTORE project. It provides you a very rough idea of what is the project "RESSTORE" about.

preclinical    resstore    motor    clinically    iib    infusion    population    diseases    scales    tissue    building    admscs    czech    life    randomised    morbidities    trial    first    cover    mechanisms    multicentre    treatment    brain    ancillary    mechanism    simulations    plan    restoring    enhanced    co    time    recovery    united    effectiveness    safety    mri    gmp    clinical    attractiveness    therapeutic    biomarkers    blood    patients    spain    france    disability    societal    therapy    underlying    cell    finland    intensive    allogenic    communication    private    trained    complementary    cognitive    intravenous    explore    sme    world    monitored    pilot    options    death    innovative    context    adipose    secondary    400    rating    economic    additionally    capacities    republic    regenerative    economics    families    health    mesenchymal    multimodal    fatal    impairments    location    stem    surely    chain    functional    evidences    predictive    stroke    full    biobanking    discovery    silico    animal    kingdom    public    effect    rehabilitation    cells    reference    competitiveness    efficacy    contribution    workforce    quality   

Project "RESSTORE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE GRENOBLE ALPES 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Project website http://www.resstore.eu
 Total cost 6˙338˙260 €
 EC max contribution 6˙338˙259 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-single-stage_RTD
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE GRENOBLE ALPES FR (SAINT MARTIN D'HERES) coordinator 1˙781˙937.00
2    UNIVERSITE JOSEPH FOURIER GRENOBLE 1 FR (GRENOBLE) coordinator 0.00
3    OY MEDFILES LTD FI (KUOPIO) participant 802˙187.00
4    ETABLISSEMENT FRANCAIS DU SANG FR (LA PLAINE SAINT DENIS) participant 799˙718.00
5    SERVICIO ANDALUZ DE SALUD ES (SEVILLA) participant 446˙825.00
6    TAMPEREEN KORKEAKOULUSAATIO SR FI (TAMPERE) participant 360˙791.00
7    FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA ES (BARCELONA) participant 350˙000.00
8    HISTOCELL SL ES (DERIO BIZKAIA) participant 327˙365.00
9    NOVADISCOVERY FR (LYON) participant 274˙375.00
10    FINOVATIS FR (LYON) participant 232˙000.00
11    ASSOCIATION GROUPE ESSEC FR (CERGY PONTOISE CEDEX) participant 200˙000.00
12    ITA-SUOMEN YLIOPISTO FI (KUOPIO) participant 185˙035.00
13    CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE FR (LA TRONCHE) participant 182˙700.00
14    SERVICIO MADRILENO DE SALUD ES (MADRID) participant 134˙600.00
15    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 130˙325.00
16    HOSPICES CIVILS DE LYON FR (LYON) participant 70˙000.00
17    FAKULTNI NEMOCNICE U SV. ANNY V BRNE CZ (Brno) participant 20˙000.00
18    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 20˙000.00
19    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 1˙700.00
20    CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON FR (BESANCON CEDEX) participant 1˙700.00
21    CENTRE HOSPITALIER SAINTE ANNE DE PARIS FR (PARIS CEDEX 14) participant 1˙700.00
22    CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE FR (TOULOUSE CEDEX 3) participant 1˙700.00
23    CHU COTE DE NACRE - CAEN FR (CAEN CEDEX 5) participant 1˙700.00
24    CHU HOPITAUX DE BORDEAUX FR (TALENCE) participant 1˙700.00
25    FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE GIRONA DOCTOR JOSEP TRUETA ES (GIRONA) participant 1˙700.00
26    FUNDACIO PRIVADA INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU ES (BARCELONA) participant 1˙700.00
27    FUNDACION INSTITUTO DE ESTUDIOS DE CIENCIAS DE LA SALUD DE CASTILLA Y LEON ES (SORIA) participant 1˙700.00
28    PIRKANMAA HOSPITAL DISTRICT FI (TAMPERE) participant 1˙700.00
29    SERVICIO DE SALUD DE CASTILLA LA MANCHA ES (TOLEDO) participant 1˙700.00
30    SERVIZO GALEGO DE SAUDE ES (Santiago de Compostela) participant 1˙700.00
31    TAMPEREEN YLIOPISTO FI (TAMPERE) participant 0.00

Map

 Project objective

Stroke is the second leading cause of death in the world population. When not fatal, stroke often results in disability, due to motor and cognitive impairments, and secondary health problems affecting not only patients but also their families. Building on emerging preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke recovery and patients quality of life. RESSTORE European multicentre randomised phase IIb will explore, for the first time, the efficacy (functional recovery) and safety of intravenous infusion of allogenic adipose tissue derived mesenchymal stem cells (ADMSCs) in 400 stroke patients. Therapeutic effects of ADMSCs will be assessed and monitored in patients using clinical rating scales, multimodal MRI and novel blood biomarkers. Additionally, the societal value and cost-effectiveness of ADMSCs-based regenerative therapy will be evaluated through health economics and predictive in silico simulations. Complementary ancillary animal studies will support the clinical trial by defining i) if the treatment response can be further enhanced by intensive rehabilitation, ii) the contribution of co-morbidities and iii) the mechanism(s) underlying the therapeutic effect. The European regenerative therapy capacities (France, Spain, Finland, United Kingdom and Czech Republic), developed in RESSTORE will cover the full value chain in the field (large scale GMP cell production, clinical testing, biomarkers discovery, understanding of the restoring mechanisms, modelling, biobanking, economic studies, exploitation and communication plan). RESSTORE will thus surely contribute, together with the workforce trained in the context of the programme, to improve its public and private (SME) competitiveness and increase the attractiveness of Europe as a reference location to develop and clinically assess new innovative therapeutic options for brain diseases.

 Deliverables

List of deliverables.
RESSTORE Website Websites, patent fillings, videos etc. 2019-10-31 10:22:32
Agencies and Ethics Approvals Documents, reports 2019-10-31 10:22:31
Registration of the clinical trial Websites, patent fillings, videos etc. 2019-10-31 10:22:31

Take a look to the deliverables list in detail:  detailed list of RESSTORE deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Lili Cui, Anaïck Moisan, Jukka Jolkkonen
Intravascular cell therapy in stroke: predicting the future trends
published pages: 63-68, ISSN: 1746-0751, DOI: 10.2217/rme-2018-0037
Regenerative Medicine 14/1 2019-10-31
2018 Olivier Detante, Jérémy Papassin
Thérapie cellulaire
published pages: 621-631, ISSN: , DOI:
Accident vasculaire cérebraux - Thérapeutique 2019-10-31
2017 Olivier Detante, Keith Muir, Jukka Jolkkonen
Cell Therapy in Stroke—Cautious Steps Towards a Clinical Treatment
published pages: , ISSN: 1868-4483, DOI: 10.1007/s12975-017-0587-6
Translational Stroke Research 2019-10-31
2015 Renard, F. Urvoy, M. Jaillard, A.
Bayesian stroke lesion estimation for automatic registration of DTI image
published pages: 8, ISSN: , DOI:
MICCAI 2019-10-31
2015 Renard, F. Urvoy, M. Jaillard, A.
Bayesian stroke lesion estimation for automatic registration of DTI image
published pages: 8, ISSN: , DOI:
MICCAI 2019-10-31
2016 Marc Hommel, Olivier Detante, Isabelle Favre, Emmanuel Touzé, Assia Jaillard
How to Measure Recovery? Revisiting Concepts and Methods for Stroke Studies
published pages: , ISSN: 1868-4483, DOI: 10.1007/s12975-016-0488-0
Translational Stroke Research 2019-10-31

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The information about "RESSTORE" are provided by the European Opendata Portal: CORDIS opendata.

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