Explore the words cloud of the RESSTORE project. It provides you a very rough idea of what is the project "RESSTORE" about.
The following table provides information about the project.
Coordinator |
UNIVERSITE GRENOBLE ALPES
There are not information about this coordinator. Please contact Fabio for more information, thanks. |
Coordinator Country | France [FR] |
Project website | http://www.resstore.eu |
Total cost | 6˙338˙260 € |
EC max contribution | 6˙338˙259 € (100%) |
Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
Code Call | H2020-PHC-2015-single-stage_RTD |
Funding Scheme | RIA |
Starting year | 2015 |
Duration (year-month-day) | from 2015-09-01 to 2020-08-31 |
Take a look of project's partnership.
Stroke is the second leading cause of death in the world population. When not fatal, stroke often results in disability, due to motor and cognitive impairments, and secondary health problems affecting not only patients but also their families. Building on emerging preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke recovery and patients quality of life. RESSTORE European multicentre randomised phase IIb will explore, for the first time, the efficacy (functional recovery) and safety of intravenous infusion of allogenic adipose tissue derived mesenchymal stem cells (ADMSCs) in 400 stroke patients. Therapeutic effects of ADMSCs will be assessed and monitored in patients using clinical rating scales, multimodal MRI and novel blood biomarkers. Additionally, the societal value and cost-effectiveness of ADMSCs-based regenerative therapy will be evaluated through health economics and predictive in silico simulations. Complementary ancillary animal studies will support the clinical trial by defining i) if the treatment response can be further enhanced by intensive rehabilitation, ii) the contribution of co-morbidities and iii) the mechanism(s) underlying the therapeutic effect. The European regenerative therapy capacities (France, Spain, Finland, United Kingdom and Czech Republic), developed in RESSTORE will cover the full value chain in the field (large scale GMP cell production, clinical testing, biomarkers discovery, understanding of the restoring mechanisms, modelling, biobanking, economic studies, exploitation and communication plan). RESSTORE will thus surely contribute, together with the workforce trained in the context of the programme, to improve its public and private (SME) competitiveness and increase the attractiveness of Europe as a reference location to develop and clinically assess new innovative therapeutic options for brain diseases.
RESSTORE Website | Websites, patent fillings, videos etc. | 2019-10-31 10:22:32 |
Agencies and Ethics Approvals | Documents, reports | 2019-10-31 10:22:31 |
Registration of the clinical trial | Websites, patent fillings, videos etc. | 2019-10-31 10:22:31 |
Take a look to the deliverables list in detail: detailed list of RESSTORE deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Lili Cui, Anaïck Moisan, Jukka Jolkkonen Intravascular cell therapy in stroke: predicting the future trends published pages: 63-68, ISSN: 1746-0751, DOI: 10.2217/rme-2018-0037 |
Regenerative Medicine 14/1 | 2019-10-31 |
2018 |
Olivier Detante, Jérémy Papassin Thérapie cellulaire published pages: 621-631, ISSN: , DOI: |
Accident vasculaire cérebraux - Thérapeutique | 2019-10-31 |
2017 |
Olivier Detante, Keith Muir, Jukka Jolkkonen Cell Therapy in Stroke—Cautious Steps Towards a Clinical Treatment published pages: , ISSN: 1868-4483, DOI: 10.1007/s12975-017-0587-6 |
Translational Stroke Research | 2019-10-31 |
2015 |
Renard, F.
Urvoy, M.
Jaillard, A. Bayesian stroke lesion estimation for automatic registration of DTI image published pages: 8, ISSN: , DOI: |
MICCAI | 2019-10-31 |
2015 |
Renard, F.
Urvoy, M.
Jaillard, A. Bayesian stroke lesion estimation for automatic registration of DTI image published pages: 8, ISSN: , DOI: |
MICCAI | 2019-10-31 |
2016 |
Marc Hommel, Olivier Detante, Isabelle Favre, Emmanuel Touzé, Assia Jaillard How to Measure Recovery? Revisiting Concepts and Methods for Stroke Studies published pages: , ISSN: 1868-4483, DOI: 10.1007/s12975-016-0488-0 |
Translational Stroke Research | 2019-10-31 |
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The information about "RESSTORE" are provided by the European Opendata Portal: CORDIS opendata.