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LSFM4LIFE SIGNED

Production and characterization of endocrine cells derived from human pancreas organoids for the cell-based therapy of type 1 diabetes

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

LSFM4LIFE project word cloud

Explore the words cloud of the LSFM4LIFE project. It provides you a very rough idea of what is the project "LSFM4LIFE" about.

cell packages preclinical human knowing screening preserve extracted chemically mass boost standardize epithelia optimize industry donors composition clinical genetic patents form promise cells stability 3d technological culture biology advantage realize progenitor adult vitro renew ductal raises pancreas diabetes stem cellular close media market disciplinary throughput characterization phenotypic capacity termed therapies cross first structures expansion molecular reproduce therapy self replication glp academic ips employing lsfm4life instability goals multilineage therapeutic hes differentiation time limitless patients organoids gmp expanded biochemical

Project "LSFM4LIFE" data sheet

The following table provides information about the project.

Coordinator	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://lsfm4life.eu/
Total cost	5˙120˙275 €
EC max contribution	4˙666˙400 € (91%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	coordinator	1˙068˙886.00
2	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	1˙432˙990.00
3	FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO Organization address address: VIA FRANCESCO SFORZA 28 city: MILANO postcode: 20122 website: www.policlinico.mi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	895˙000.00
4	CELLENDES GMBH CELLENDES GMBH Organization address address: MARKWIESENSTR 55 city: REUTLINGEN postcode: 72770 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (REUTLINGEN)	participant	589˙233.00
5	LONZA NETHERLANDS BV LONZA NETHERLANDS BV Organization address address: OXFORDLAAN 70 city: MAASTRICHT postcode: 6229 EV website: www.pharmacell.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	463˙950.00
6	SPARKS & CO SPARKS & CO Organization address address: 66 AVENUE DES CHAMPS ELYSEES ESPACE 41 city: PARIS postcode: 75008 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	133˙153.00
7	PROSCIENCIA BERATUNGS-GMBH PROSCIENCIA BERATUNGS-GMBH Organization address address: AUF DER HEIDE 11 city: LUEBECK postcode: 23558 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUEBECK)	participant	83˙186.00
8	INSPHERO AG INSPHERO AG Organization address address: WAGISTRASSE 27 city: SCHLIEREN postcode: 8952 website: www.insphero.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (SCHLIEREN)	participant	0.00

Map

Project objective

Self-renew and multilineage potential characterize stem cells. We have recently described that pancreas progenitor cells extracted from adult donors can be expanded long-term in vitro into 3D structures, which we have termed organoids. Pancreas organoids reproduce in vitro all the features of pancreas ductal epithelia, and have a limitless expansion potential. Thus, pancreas organoids promise to boost cell therapy of type 1 diabetes. We have recently observed that progenitor cells organoids preserve their genetic stability over a long time in culture. That represents an advantage, when compared to iPS or hES derived approaches, where genetic instability raises concerns for their future therapeutic applications. While progenitor organoids are promising for the future of cell therapy, bringing stem cell-based therapies to patients requires a reliable characterization (“knowing what the cells do and how they do it”, i.e. a phenotypic and molecular biology characterization), chemically well-defined culture media, and the capacity of mass-production under GLP/GMP conditions. The LSFM4LIFE consortium aims to the mass production of pancreas organoids for the cellular therapy of type 1 diabetes. The goals of the project are: (1) optimize growth and differentiation of human pancreas stem-cell organoids by employing phenotypic and molecular high-throughput screening (2) standardize the growth and differentiation of the organoids under well-defined biochemical conditions, and (3) achieve GLP/GMP-production of the human organoids for preclinical studies and phase I clinical studies. The close collaboration in the consortium between academic researchers and industry, as well as its cross-disciplinary composition, are essential to realize the goals of the project. The work packages of the project will have a technological impact in the form of patents and first market replication.

Deliverables

List of deliverables.
Project website	Websites, patent fillings, videos etc.	2020-01-23 09:37:22
Communication materials: Leaflet, poster, presentation and infographics to present the project	Websites, patent fillings, videos etc.	2020-01-23 09:37:22
\"Newsletter #1\"	Websites, patent fillings, videos etc.	2020-01-23 09:37:22
Project-related video	Websites, patent fillings, videos etc.	2020-01-23 09:37:21

Take a look to the deliverables list in detail: detailed list of LSFM4LIFE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J. Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D. Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy, Meritxell Huch Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids published pages: , ISSN: 1471-213X, DOI: 10.1186/s12861-020-0209-5	BMC Developmental Biology 20/1	2020-03-31
2020	Marta Dossena, Roberta Piras, Alessandro Cherubini, Mario Barilani, Erica Dugnani, Francesca Salanitro, Till Moreth, Francesco Pampaloni, Lorenzo Piemonti, Lorenza Lazzari Standardized GMP-compliant scalable production of human pancreas organoids published pages: , ISSN: 1757-6512, DOI: 10.1186/s13287-020-1585-2	Stem Cell Research & Therapy 11/1	2020-03-31
2019	Katharina HÃ¶tte, Michael Koch, Lotta Hof, Marcel Tuppi, Till Moreth, Monique M. A. Verstegen, Luc J. W. van der Laan, Ernst H. K. Stelzer, Francesco Pampaloni Ultra-thin fluorocarbon foils optimise multiscale imaging of three-dimensional native and optically cleared specimens published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-53380-2	Scientific Reports 9/1	2020-03-31
2017	I. Smyrek, E. H. K. Stelzer Quantitative three-dimensional evaluation of immunofluorescence staining for large whole mount spheroids with light sheet microscopy published pages: 484, ISSN: 2156-7085, DOI: 10.1364/boe.8.000484	Biomedical Optics Express 8/2	2020-01-23
2018	Steffen Rulands, Fabienne Lescroart, Samira Chabab, Christopher J. Hindley, Nicole Prior, Magdalena K. Sznurkowska, Meritxell Huch, Anna Philpott, Cedric Blanpain, Benjamin D. Simons Universality of clone dynamics during tissue development published pages: 469-474, ISSN: 1745-2473, DOI: 10.1038/s41567-018-0055-6	Nature Physics 14/5	2020-01-23
2017	Francesco Pampaloni, Benjamin Mayer, Konstantin Kabat Vel-Job, Nariman Ansari, Katharina HÃ¶tte, Donat KÃ¶gel, Ernst H. K. Stelzer A Novel Cellular Spheroid-Based Autophagy Screen Applying Live Fluorescence Microscopy Identifies Nonactin as a Strong Inducer of Autophagosomal Turnover published pages: 558-570, ISSN: 2472-5552, DOI: 10.1177/2472555217696798	SLAS DISCOVERY: Advancing Life Sciences R&D 22/5	2020-01-23
2017	Laura Broutier, Gianmarco Mastrogiovanni, Monique MA Verstegen, Hayley E Francies, Lena Morrill GavarrÃ³, Charles R Bradshaw, George E Allen, Robert Arnes-Benito, Olga Sidorova, Marcia P Gaspersz, Nikitas Georgakopoulos, Bon-Kyoung Koo, Sabine Dietmann, Susan E Davies, Raaj K Praseedom, Ruby Lieshout, Jan N M IJzermans, Stephen J Wigmore, Kourosh Saeb-Parsy, Mathew J Garnett, Luc JW van der Laan, Meritxell Huch Human primary liver cancerâ€“derived organoid cultures for disease modeling and drug screening published pages: 1424-1435, ISSN: 1078-8956, DOI: 10.1038/nm.4438	Nature Medicine 23/12	2020-01-23
2018	Mariele ViganÃ², Silvia Budelli, Cristiana Lavazza, Tiziana Montemurro, Elisa Montelatici, Stefania de Cesare, Lorenza Lazzari, Anna Rosa Orlandi, Giovanna Lunghi, Rosaria Giordano Tips and Tricks for Validation of Quality Control Analytical Methods in Good Manufacturing Practice Mesenchymal Stromal Cell Production published pages: 1-16, ISSN: 1687-966X, DOI: 10.1155/2018/3038565	Stem Cells International 2018	2020-01-23
2017	Mariele ViganÃ², Rosaria Giordano, Lorenza Lazzari Challenges of running a GMP facility for regenerative medicine in a public hospital published pages: 803-813, ISSN: 1746-0751, DOI: 10.2217/rme-2017-0051	Regenerative Medicine 12/7	2020-01-23

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