Explore the words cloud of the TECHNOBEAT project. It provides you a very rough idea of what is the project "TECHNOBEAT" about.
The following table provides information about the project.
Coordinator |
MEDIZINISCHE HOCHSCHULE HANNOVER
Organization address contact info |
Coordinator Country | Germany [DE] |
Project website | http://www.mh-hannover.de/technobeat.html |
Total cost | 5˙968˙850 € |
EC max contribution | 5˙968˙850 € (100%) |
Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
Code Call | H2020-PHC-2015-two-stage |
Funding Scheme | RIA |
Starting year | 2016 |
Duration (year-month-day) | from 2016-01-01 to 2019-12-31 |
Take a look of project's partnership.
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1 | MEDIZINISCHE HOCHSCHULE HANNOVER | DE (HANNOVER) | coordinator | 1˙245˙950.00 |
2 | UNIVERSITAIR MEDISCH CENTRUM UTRECHT | NL (UTRECHT) | participant | 749˙750.00 |
3 | DASGIP INFORMATION AND PROCESS TECHNOLOGY GMBH | DE (JULICH) | participant | 729˙200.00 |
4 | THE UNIVERSITY OF SHEFFIELD | UK (SHEFFIELD) | participant | 650˙000.00 |
5 | KADIMASTEM LTD | IL (NES ZIONA) | participant | 649˙950.00 |
6 | ACADEMISCH ZIEKENHUIS LEIDEN | NL (LEIDEN) | participant | 649˙750.00 |
7 | OVIZIO IMAGING SYSTEMS | BE (BRUXELLES) | participant | 649˙375.00 |
8 | PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG - PRIVATSTIFTUNG | AT (SALZBURG) | participant | 644˙875.00 |
Cardiovascular diseases including myocardial infarction (MI), which entails the irreversible loss of heart muscle tissue, constitute a major socio-economic burden in global healthcare. With whole organ transplantation as the only treatment option for end-stage heart failure, MI patients could particularly benefit from advanced cell therapies aimed at the functional reconstitution of damaged hearts. Human induced pluripotent stem cells (hiPSCs) can be derived by reprogramming patients’ somatic cells. In contrast to adult (stem) cells e.g. from blood, bone marrow or the heart, hiPSCs have unlimited expandability and differentiation potential into all relevant cell types including cardiomyocytes, endothelial cells, pericytes and connective tissue-forming cells, making them highly attractive as a universal cell source for organ repair. However, technologies for the robust therapeutic scale production of hiPSC-derived progenies in line with GMP standards and at reasonable cost are currently lacking. TECHNOBEAT’s ultimate objectives are 1) to advance therapeutic scale cell production through innovative bioreactor technologies and novel cell monitoring tools, and 2) to develop regulatory compliant bioprocessing of innovative iPSC-based cardiac µ-tissue. The clinical translation of cardiac µ-tissue will require 3) the development and application of tools for improved cell delivery and longitudinal in vivo monitoring of cell grafts, and 4) proof-of-concept for safety and functional integration in physiologically relevant preclinical models of cellular heart repair. Through its interdisciplinary excellence, TECHNOBEAT’s consortium of leading European stem cell researchers, clinicians, tissue-, bioprocess-, and technical- engineers in industry and academia is ideally positioned to address these ambitious objectives. It will provide new treatment options for suffering patients and increase Europe’s attractiveness as a hub for innovative medical technologies.
Draft and disseminate press release on project initiation | Websites, patent fillings, videos etc. | 2019-05-30 11:39:30 |
Website launched, central data base accessible to all partners | Websites, patent fillings, videos etc. | 2019-05-30 11:39:30 |
Take a look to the deliverables list in detail: detailed list of TECHNOBEAT deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2017 |
Verena Schwach, Arie O. Verkerk, Mervyn Mol, Jantine J. Monshouwer-Kloots, Harsha D. Devalla, Valeria V. Orlova, Konstantinos Anastassiadis, Christine L. Mummery, Richard P. Davis, Robert Passier A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes published pages: 1765-1779, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2017.10.024 |
Stem Cell Reports 9/6 | 2020-03-24 |
2018 |
Oleh V. Halaidych, Francijna van den Hil, Christine L. Mummery, Valeria V. Orlova Microfluidic Assay for the Assessment of Leukocyte Adhesion to Human Induced Pluripotent Stem Cell-derived Endothelial Cells (hiPSC-ECs) published pages: , ISSN: 1940-087X, DOI: 10.3791/58678 |
Journal of Visualized Experiments 141 | 2020-03-24 |
2019 |
Anais Sahabian, Malte Sgodda, Ortwin Naujok, Rabea Dettmer, Julia Dahlmann, Felix Manstein, Tobias Cantz, Robert Zweigerdt, Ulrich Martin, Ruth Olmer Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential published pages: 1571, ISSN: 2073-4409, DOI: 10.3390/cells8121571 |
Cells 8/12 | 2020-03-24 |
2019 |
Xu Cao, Gopala K. Yakala, Francijna E. van den Hil, Amy Cochrane, Christine L. Mummery, Valeria V. Orlova Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives published pages: 1282-1297, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2019.05.003 |
Stem Cell Reports 12/6 | 2020-03-24 |
2019 |
Oleh V. Halaidych, Amy Cochrane, Francijna E. van den Hil, Christine L. Mummery, Valeria V. Orlova Quantitative Analysis of Intracellular Ca2+ Release and Contraction in hiPSC-Derived Vascular Smooth Muscle Cells published pages: 647-656, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2019.02.003 |
Stem Cell Reports 12/4 | 2020-03-24 |
2019 |
Amy Cochrane, Hugo J. Albers, Robert Passier, Christine L. Mummery, Albert van den Berg, Valeria V. Orlova, Andries D. van der Meer Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology published pages: 68-77, ISSN: 0169-409X, DOI: 10.1016/j.addr.2018.06.007 |
Advanced Drug Delivery Reviews 140 | 2020-03-24 |
2019 |
Mees N. S. de Graaf, Amy Cochrane, Francijna E. van den Hil, Wesley Buijsman, Andries D. van der Meer, Albert van den Berg, Christine L. Mummery, Valeria V. Orlova Scalable microphysiological system to model three-dimensional blood vessels published pages: 26105, ISSN: 2473-2877, DOI: 10.1063/1.5090986 |
APL Bioengineering 3/2 | 2020-03-24 |
2019 |
Oleh V. Halaidych, Christine L. Mummery, Valeria V. Orlova Quantifying Ca2+ signaling and contraction in vascular pericytes and smooth muscle cells published pages: 112-118, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2019.03.143 |
Biochemical and Biophysical Research Communications 513/1 | 2020-03-24 |
2019 |
Alexandra Haase, Wolfgang Glienke, Lena Engels, Gudrun Göhring, Ruth Esser, Lubomir Arseniev, Ulrich Martin GMP-compatible manufacturing of three iPS cell lines from human peripheral blood published pages: 101394, ISSN: 1873-5061, DOI: 10.1016/j.scr.2019.101394 |
Stem Cell Research 35 | 2020-03-24 |
2019 |
Gesa L. Tiemeier, Gangqi Wang, Sébastien J. Dumas, Wendy M.P.J. Sol, M. Cristina Avramut, Tobias Karakach, Valeria V. Orlova, Cathelijne W. van den Berg, Christine L. Mummery, Peter Carmeliet, Bernard M. van den Berg, Ton J. Rabelink Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation published pages: 803-816, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2019.10.005 |
Stem Cell Reports 13/5 | 2020-03-24 |
2018 |
Gesa-Maria Gieseler, Kimia Ekramzadeh, Volker Nölle, Svitlana Malysheva, Henning Kempf, Sascha Beutel, Robert Zweigerdt, Ulrich Martin, Ursula Rinas, Thomas Scheper, Iliyana Pepelanova Solubilization and renaturation of biologically active human bone morphogenetic protein-4 from inclusion bodies published pages: e00249, ISSN: 2215-017X, DOI: 10.1016/j.btre.2018.e00249 |
Biotechnology Reports 18 | 2019-04-30 |
2018 |
Jonas Christoffersson, Florian Meier, Henning Kempf, Kristin Schwanke, Michelle Coffee, Mario Beilmann, Robert Zweigerdt, Carl-Fredrik Mandenius A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device published pages: 36, ISSN: 2306-5354, DOI: 10.3390/bioengineering5020036 |
Bioengineering 5/2 | 2019-04-30 |
2017 |
Medicine Maker/Stephanie Sutton, Katharina Kinast, Ulrike Becken, Robert Zweigerdt Listen to the Heartbeat published pages: , ISSN: , DOI: |
2019-04-30 | |
2018 |
Mania Ackermann, Henning Kempf, Miriam Hetzel, Christina Hesse, Anna Rafiei Hashtchin, Kerstin Brinkert, Juliane Wilhelmine Schott, Kathrin Haake, Mark Philipp Kühnel, Silke Glage, Constanca Figueiredo, Danny Jonigk, Katherina Sewald, Axel Schambach, Sabine Wronski, Thomas Moritz, Ulrich Martin, Robert Zweigerdt, Antje Munder, Nico Lachmann Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07570-7 |
Nature Communications 9/1 | 2019-04-30 |
2018 |
Oleh V. Halaidych, Christian Freund, Francijna van den Hil, Daniela C.F. Salvatori, Mara Riminucci, Christine L. Mummery, Valeria V. Orlova Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells published pages: 1642-1656, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.03.012 |
Stem Cell Reports 10/5 | 2019-04-30 |
2019 |
Rosalinda Madonna, Linda W Van Laake, Hans Erik Botker, Sean M Davidson, Raffaele De Caterina, Felix B Engel, Thomas Eschenhagen, Francesco Fernandez-Aviles, Derek J Hausenloy, Jean-Sebastien Hulot, Sandrine Lecour, Jonathan Leor, Philippe Menasché, Maurizio Pesce, Cinzia Perrino, Fabrice Prunier, Sophie Van Linthout, Kirsti Ytrehus, Wolfram-Hubertus Zimmermann, Peter Ferdinandy, Joost P G Sluijter ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvz010 |
Cardiovascular Research | 2019-04-30 |
2018 |
LABO Internationale Experten beim zweiten Stem Cell Community DAy published pages: , ISSN: , DOI: |
LABO 7-8/2018 | 2019-04-30 |
2018 |
Cell gene Therapy Insights & DASGIP, Philip Nold A question of consistency: biopharma know-how meets bioreactor innovation in upstream bioprocessing published pages: , ISSN: , DOI: |
Cell Gene Therapy Insights | 2019-04-30 |
2018 |
Bogdan Iorga, Kristin Schwanke, Natalie Weber, Meike Wendland, Stephan Greten, Birgit Piep, Cristobal G. dos Remedios, Ulrich Martin, Robert Zweigerdt, Theresia Kraft, Bernhard Brenner Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2017.01111 |
Frontiers in Physiology 8 | 2019-04-30 |
2018 |
Natali Froese, Honghui Wang, Carolin Zwadlo, Yong Wang, Andrea Grund, Anna Gigina, Melanie Hofmann, Katja Kilian, Gesine Scharf, Mortimer Korf-Klingebiel, Anna Melchert, Maria Elena Ricci Signorini, Caroline Halloin, Robert Zweigerdt, Ulrich Martin, Ina Gruh, Kai C. Wollert, Robert Geffers, Johann Bauersachs, Joerg Heineke Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice published pages: 114-124, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2018.08.011 |
Journal of Molecular and Cellular Cardiology 122 | 2019-04-30 |
2018 |
Erika Gaspari, Annika Franke, Diana Robles-Diaz, Robert Zweigerdt, Ingo Roeder, Thomas Zerjatke, Henning Kempf Paracrine mechanisms in early differentiation of human pluripotent stem cells: Insights from a mathematical model published pages: 1-7, ISSN: 1873-5061, DOI: 10.1016/j.scr.2018.07.025 |
Stem Cell Research 32 | 2019-04-30 |
2018 |
Drug Target Review & DASGIP, Philip Nold Expert View: Large-scale stem cell expansion and differentiation published pages: , ISSN: , DOI: |
Drug Target Review | 2019-04-30 |
2017 |
Juan Antonio Guadix, Valeria V. Orlova, Elisa Giacomelli, Milena Bellin, Marcelo C. Ribeiro, Christine L. Mummery, José M. Pérez-Pomares, Robert Passier Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells published pages: 1754-1764, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2017.10.023 |
Stem Cell Reports 9/6 | 2019-04-30 |
2018 |
Dorothee Eicke, Anja Baigger, Kai Schulze, Sharissa L. Latham, Caroline Halloin, Robert Zweigerdt, Carlos A. Guzman, Rainer Blasczyk, Constança Figueiredo Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28459-x |
Scientific Reports 8/1 | 2019-04-30 |
2018 |
Lothar Koch, Andrea Deiwick, Annika Franke, Kristin Schwanke, Axel Haverich, Robert Zweigerdt, Boris Chichkov Laser bioprinting of human induced pluripotent stem cells—the effect of printing and biomaterials on cell survival, pluripotency, and differentiation published pages: 35005, ISSN: 1758-5090, DOI: 10.1088/1758-5090/aab981 |
Biofabrication 10/3 | 2019-04-30 |
2018 |
Kyriakides, O., Halliwell, J., Andrews, P. Engineering and applicaions of pluripotent stem cells - Acquired genetic and epigenetic varaition in human pluripotent stem cells published pages: , ISSN: , DOI: |
2019-04-30 | |
2018 |
Sarah Hochmann, Michaela Mittermeir, Radmila Santic, Frieder Koszik, Lanay Griessner, Alina Sarah Sonderegger, Thomas Hoffmann, Elisabeth Russe, Sandra Scheiblhofer, Richard Weiss, Markus Mandler, Achim Schneeberger, Dirk Strunk Evaluation of modified Interferon alpha mRNA constructs for the treatment of non-melanoma skin cancer published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-31061-w |
Scientific Reports 8/1 | 2019-04-30 |
2018 |
Ramona Weist, Thilo Flörkemeier, Yvonne Roger, Sandra Noack, Annika Franke, Kristin Schwanke, Robert Zweigerdt, Ulrich Martin, Elmar Willbold, Andrea Hoffmann Differential Expression of Cholinergic System Components in Human Induced Pluripotent Stem Cells, Bone Marrow-Derived Multipotent Stromal Cells, and Induced Pluripotent Stem Cell-Derived Multipotent Stromal Cells published pages: 166-183, ISSN: 1547-3287, DOI: 10.1089/scd.2017.0162 |
Stem Cells and Development 27/3 | 2019-04-30 |
2018 |
Hanna Wolling, Sarah A. Konze, Anne Höfer, Jelena Erdmann, Andreas Pich, Robert Zweigerdt, Falk F. R. Buettner Quantitative Secretomics Reveals Extrinsic Signals Involved in Human Pluripotent Stem Cell Cardiomyogenesis published pages: 1800102, ISSN: 1615-9853, DOI: 10.1002/pmic.201800102 |
PROTEOMICS 18/14 | 2019-04-30 |
2017 |
Medicine Maker/Stephanie Sutton, Katharina Kinast, Ulrike Becken, Robert Zweigerdt Collaboration is key published pages: , ISSN: , DOI: |
The Medicine Maker’s Advancing Medicine supplement (print) | 2019-04-30 |
2018 |
Ruth Olmer, Lena Engels, Abdulai Usman, Sandra Menke, Muhammad Nasir Hayat Malik, Frank Pessler, Gudrun Göhring, Dorothee Bornhorst, Svenja Bolten, Salim Abdelilah-Seyfried, Thomas Scheper, Henning Kempf, Robert Zweigerdt, Ulrich Martin Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture published pages: 1657-1672, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.03.017 |
Stem Cell Reports 10/5 | 2019-04-30 |
2017 |
Ulrike Becken/ DASGIP \"Editorial \"\"Controlled Stem Cell Production\"\"\" published pages: , ISSN: , DOI: |
Eppendorf Customer Magazine BioNews, H2/2017Â | 2019-04-30 |
2018 |
Alain van Mil, Geerthe Margriet Balk, Klaus Neef, Jan Willem Buikema, Folkert W Asselbergs, Sean M Wu, Pieter A Doevendans, Joost P G Sluijter Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvy208 |
Cardiovascular Research | 2019-04-30 |
2018 |
Allison TF, Andrews PW, Avior Y, Barbaric I, Benvenisty N, Bock C, Brehm J, Brüstle O, Damjanov I, Elefanty A, Felkner D, Gokhale PJ, Halbritter F, Healy LE, Hu TX, Knowles BB, Loring JF, Ludwig TE, Mayberry R, Micallef S, Mohamed JS, Müller FJ, Mummery CL, Nakatsuji N, Ng ES, Oh SKW, O\'Shea O, Pera MF, Reubinoff B, Robson P, Rossant J, Schuldt BM, Solter D, Sourris K, Stacey G, Stanley EG, Suemori H, Takahashi K, Yamanaka S. Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04011-3 |
Nature Communications 9/1 | 2019-04-30 |
2018 |
Michaela Oeller, Sandra Laner-Plamberger, Sarah Hochmann, Nina Ketterl, Martina Feichtner, Gabriele Brachtl, Anna Hochreiter, Cornelia Scharler, Lara Bieler, Pasquale Romanelli, Sebastien Couillard-Despres, Elisabeth Russe, Katharina Schallmoser, Dirk Strunk Selection of Tissue Factor-Deficient Cell Transplants as a Novel Strategy for Improving Hemocompatibility of Human Bone Marrow Stromal Cells published pages: 1421-1434, ISSN: 1838-7640, DOI: 10.7150/thno.21906 |
Theranostics 8/5 | 2019-04-30 |
2018 |
Christoph Lipps, Franziska Klein, Tom Wahlicht, Virginia Seiffert, Milada Butueva, Jeannette Zauers, Theresa Truschel, Martin Luckner, Mario Köster, Roderick MacLeod, Jörn Pezoldt, Jochen Hühn, Qinggong Yuan, Peter Paul Müller, Henning Kempf, Robert Zweigerdt, Oliver Dittrich-Breiholz, Thomas Pufe, Rainer Beckmann, Wolf Drescher, Jose Riancho, Carolina Sañudo, Thomas Korff, Bertram Opalka, Vera Rebmann, Joachim R. Göthert, Paula M. Alves, Michael Ott, Roland Schucht, Hansjörg Hauser, Dagmar Wirth, Tobias May Expansion of functional personalized cells with specific transgene combinations published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03408-4 |
Nature Communications 9/1 | 2019-04-30 |
2018 |
Miguel Castilho, Alain van Mil, Malachy Maher, Corina H. G. Metz, Gernot Hochleitner, Jürgen Groll, Pieter A. Doevendans, Keita Ito, Joost P. G. Sluijter, Jos Malda Melt Electrowriting Allows Tailored Microstructural and Mechanical Design of Scaffolds to Advance Functional Human Myocardial Tissue Formation published pages: 1803151, ISSN: 1616-301X, DOI: 10.1002/adfm.201803151 |
Advanced Functional Materials 28/40 | 2019-04-30 |
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The information about "TECHNOBEAT" are provided by the European Opendata Portal: CORDIS opendata.