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SyBil-AA SIGNED

Systems Biology of Alcohol Addiction: Modeling and validating disease state networks in human and animal brains for understanding pathophysiolgy, predicting outcomes and improving therapy

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SyBil-AA project word cloud

Explore the words cloud of the SyBil-AA project. It provides you a very rough idea of what is the project "SyBil-AA" about.

complementary directed fmri brain networks causes tested prone interventions remodeling models aberrant health proneness largely death countries skills expertise human prescribed assembled class translational animals missing proof interdisciplinary addiction magnetic framework utilize laboratory predict predictive therapies imaging alcohol fill showing possibility guide theoretical positively unmet resonance experimental network world patients global sites biology societies preventable rational hubs clinical modeling discovery data experiments neurochemical animal serious therapeutic relapse transferred uses options treatment strategies strategy resilience primary humans disorder normalized predictions ranks verified eight successful gap functional mathematical limited disabilities dynamics rigorously population

Project "SyBil-AA" data sheet

The following table provides information about the project.

Coordinator	ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT Organization address address: Square J 5 city: MANNHEIM postcode: 68159 website: www.zi-mannheim.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://sybil-aa.eu/
Total cost	5˙759˙923 €
EC max contribution	5˙759˙923 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT Organization address address: Square J 5 city: MANNHEIM postcode: 68159 website: www.zi-mannheim.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MANNHEIM)	coordinator	1˙861˙352.00
2	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	550˙000.00
3	THE UNIVERSITY OF SUSSEX THE UNIVERSITY OF SUSSEX Organization address address: SUSSEX HOUSE FALMER city: BRIGHTON postcode: BN1 9RH website: http://www.sussex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRIGHTON)	participant	449˙943.00
4	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	448˙258.00
5	LINKOPINGS UNIVERSITET LINKOPINGS UNIVERSITET Organization address address: CAMPUS VALLA city: LINKOPING postcode: 581 83 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LINKOPING)	participant	416˙625.00
6	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	408˙687.00
7	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	389˙791.00
8	BEN-GURION UNIVERSITY OF THE NEGEV BEN-GURION UNIVERSITY OF THE NEGEV Organization address address: . city: BEER SHEVA postcode: 84105 website: www.bgu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (BEER SHEVA)	participant	259˙252.00
9	UNIVERSITEIT LEIDEN UNIVERSITEIT LEIDEN Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2311 EZ website: www.universiteitleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	250˙000.00
10	INSTITUTUL ROMAN DE STIINTA SI TEHNOLOGIE INSTITUTUL ROMAN DE STIINTA SI TEHNOLOGIE Organization address address: STR. SATURN NR. 24-26 city: CLUJ-NAPOCA postcode: 400504 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RO (CLUJ-NAPOCA)	participant	227˙826.00
11	ASOCIATIA TRANSYLVANIAN INSTITUTE OF NEUROSCIENCE ASOCIATIA TRANSYLVANIAN INSTITUTE OF NEUROSCIENCE Organization address address: PIATA TIMOTEI CIPARIU NR. 9 BL. IA SCA.2 AP.20 city: CLUJ NAPOCA postcode: 400191 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RO (CLUJ NAPOCA)	participant	186˙298.00
12	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	161˙140.00
13	BRAIN RESEARCH AND DEVELOPMENT SERVICES LTD BRAIN RESEARCH AND DEVELOPMENT SERVICES LTD Organization address address: 19 HARTOM STREET BYNET BUILDING 3RD FLOOR HAR HOTZ city: JERUSALEM postcode: 9777518 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (JERUSALEM)	participant	150˙747.00
14	METANOMICS HEALTH GMBH METANOMICS HEALTH GMBH Organization address address: Tegeler Weg 33 city: Berlin postcode: 10589 website: www.metanomics-health.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Berlin)	participant	0.00
15	OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG Organization address address: UNIVERSITAETSPLATZ 2 city: MAGDEBURG postcode: 39106 website: www.ovgu.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MAGDEBURG)	participant	0.00

Map

Project objective

Alcohol addiction ranks among the primary global causes of preventable death and disabilities in human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Within this project, we will utilize a translational approach based on clinical studies and animal experiments to fill this gap. We will provide a novel discovery strategy based on systems biology concepts that uses mathematical and network theoretical models to identify brain sites and functional networks that can be targeted specifically by therapeutic interventions. To build predictive models of the ‘relapse-prone’ state of brain networks we will use magnetic resonance imaging and neurochemical data from patients and laboratory animals. The mathematical models will be rigorously tested through experimental procedures aimed to guide network dynamics towards increased resilience. We expect to identify hubs that promote ‘relapse-proneness’ and to predict how aberrant network states could be normalized. Proof of concept experiments in animal will need to demonstrate this possibility by showing directed remodeling of functional brain networks by targeted interventions prescribed by the theoretical framework. Thus, our translational goal will be achieved by a theoretical and experimental framework for making predictions based on fMRI and mathematical modeling, which is verified in animals, and which can be transferred to humans. To achieve this goal we have assembled an interdisciplinary consortium (eight European countries) of world-class expertise in all complementary skills required for the project. If successful this project will positively impact on the development of new therapies for a disorder with largely unmet clinical needs, and thus help to address a serious and widespread health problem in our societies.

Deliverables

List of deliverables.
Targeted Publication in Addiction-related journals	Documents, reports	2020-01-15 09:46:11
Kick-off Meeting report	Documents, reports	2020-01-15 09:46:10
External SyBil-AA website and promotion video	Websites, patent fillings, videos etc.	2020-01-15 09:46:10

Take a look to the deliverables list in detail: detailed list of SyBil-AA deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Patrick Bach, Anne Koopmann, Jan Malte Bumb, Sina Zimmermann, Sina BÃ¼hler, Iris Reinhard, Stephanie H. Witt, Marcella Rietschel, Sabine VollstÃ¤dt-Klein, Falk Kiefer Oxytocin attenuates neural response to emotional faces in social drinkers: an fMRI study published pages: , ISSN: 0940-1334, DOI: 10.1007/s00406-020-01115-0	European Archives of Psychiatry and Clinical Neuroscience	2020-03-05
2019	Stefano Tambalo, Giulia Scuppa, Angelo Bifone Segmented Echo Planar Imaging Improves Detection of Subcortical Functional Connectivity Networks in the Rat Brain published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37863-2	Scientific Reports 9/1	2020-02-19
2020	Franziska Weiss, Vera Zamoscik, Stephanie N.L. Schmidt, Patrick Halli, Peter Kirsch, Martin Fungisai Gerchen Just a very expensive breathing training? Risk of respiratory artefacts in functional connectivity-based real-time fMRI neurofeedback published pages: 116580, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2020.116580	NeuroImage 210	2020-02-13
2019	Fathizadeh, F.; Mitricheva, E.; Kimura, R.; Logothetis, N.; Noori, H. Signal detection in extracellular neural ensemble recordings using higher criticism published pages: , ISSN: , DOI:	5	2020-01-30
2018	Martin Fungisai Gerchen, Alena Rentsch, Martina Kirsch, Falk Kiefer, Peter Kirsch Shifts in the functional topography of frontal cortexâ€striatum connectivity in alcohol use disorder published pages: 1245-1253, ISSN: 1355-6215, DOI: 10.1111/adb.12692	Addiction Biology 24/6	2020-01-30
2019	Lisamon Egenrieder, Ekaterina Mitricheva, Rainer Spanagel, Hamid R. Noori No basal or drugâ€induced sex differences in striatal dopaminergic levels: a cluster and metaâ€analysis of rat microdialysis studies published pages: , ISSN: 0022-3042, DOI: 10.1111/jnc.14911	Journal of Neurochemistry	2020-01-30
2018	RÄƒzvan GÄƒmÄƒnuÅ£, Henry Kennedy, ZoltÃ¡n Toroczkai, MÃ¡ria Ercsey-Ravasz, David C. Van Essen, Kenneth Knoblauch, Andreas Burkhalter The Mouse Cortical Connectome, Characterized by an Ultra-Dense Cortical Graph, Maintains Specificity by Distinct Connectivity Profiles published pages: 698-715.e10, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.12.037	Neuron 97/3	2020-01-30
2019	Irene Perini, Robin KÃ¤mpe, Theodor Arlestig, Hanna Karlsson, Andreas LÃ¶fberg, Michal Pietrzak, Abraham Zangen, Markus Heilig Repetitive transcranial magnetic stimulation targeting the insular cortex for reduction of heavy drinking in treatment-seeking alcohol-dependent subjects: a randomized controlled trial published pages: , ISSN: 0893-133X, DOI: 10.1038/s41386-019-0565-7	Neuropsychopharmacology	2020-01-30
2019	Dongmei Shi, Anna Levina, Hamid R. Noori Refined parcellation of the nervous system by algorithmic detection of hidden features within communities published pages: , ISSN: 2470-0045, DOI: 10.1103/physreve.100.012301	Physical Review E 100/1	2020-01-30
2019	Ekaterina Mitricheva, Rui Kimura, Nikos K. Logothetis, Hamid R. Noori Neural substrates of sexual arousal are not sex dependent published pages: 15671-15676, ISSN: 0027-8424, DOI: 10.1073/pnas.1904975116	Proceedings of the National Academy of Sciences 116/31	2020-01-30
2020	Ciuparu A., Nagy-DÄƒbÃ¢can A., Muresan R.C. Soft++, a multi-parametric non-saturating non-linearity that improves convergence in deep neural architectures published pages: , ISSN: 0925-2312, DOI:	Neurocomputing	2020-01-30
2019	Christina Dinter, Derik Hermann, Judith Heckmann, Holger Hill, Iris Reinhard, Sabine VollstÃ¤dtâ€Klein, Peter Kirsch, Falk Kiefer Reconsolidation impairment of reward memory by stimulating stress response published pages: , ISSN: 1355-6215, DOI: 10.1111/adb.12712	Addiction Biology 25/1	2020-01-30
2019	Markus Heilig, Eric Augier, Simone Pfarr, Wolfgang H. Sommer Developing neuroscience-based treatments for alcohol addiction: A matter of choice? published pages: , ISSN: 2158-3188, DOI: 10.1038/s41398-019-0591-6	Translational Psychiatry 9/1	2020-01-15
2019	Silvia De Santis, Wolfgang H. Sommer, Santiago Canals Detecting Alcohol-Induced Brain Damage Noninvasively Using Diffusion Tensor Imaging published pages: 4187-4189, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.9b00481	ACS Chemical Neuroscience 10/10	2020-01-15
2019	Giulia Scuppa, Stefano Tambalo, Simone Pfarr, Wolfgang H. Sommer, Angelo Bifone Aberrant insular cortex connectivity in abstinent alcohol-dependent rats is reversed by dopamine D3 receptor blockade published pages: , ISSN: 1355-6215, DOI: 10.1111/adb.12744	Addiction Biology	2020-01-15
2018	Gino Del Ferraro, Andrea Moreno, Byungjoon Min, Flaviano Morone, Ãšrsula PÃ©rez-RamÃrez, Laura PÃ©rez-Cervera, Lucas C. Parra, Andrei Holodny, Santiago Canals, HernÃ¡n A. Makse Finding influential nodes for integration in brain networks using optimal percolation theory published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04718-3	Nature Communications 9/1	2020-01-15
2018	Aleksandra M. Herman, Hugo D. Critchley, Theodora Duka Binge drinking is associated with attenuated frontal and parietal activation during successful response inhibition in fearful context published pages: , ISSN: 0953-816X, DOI: 10.1111/ejn.14108	European Journal of Neuroscience	2020-01-15
2018	Carlo Nicolini, Vladimir Vlasov, Angelo Bifone Thermodynamics of network model fitting with spectral entropies published pages: , ISSN: 2470-0045, DOI: 10.1103/PhysRevE.98.022322	Physical Review E 98/2	2020-01-15
2017	Zsolt I. LÃ¡zÃ¡r, IstvÃ¡n Papp, Levente Varga, Ferenc JÃ¡rai-SzabÃ³, DÃ¡vid Deritei, MÃ¡ria Ercsey-Ravasz Stochastic graph Voronoi tessellation reveals community structure published pages: , ISSN: 2470-0045, DOI: 10.1103/PhysRevE.95.022306	Physical Review E 95/2	2020-01-15
2017	CÃ©cile Bordier, Carlo Nicolini, Angelo Bifone Graph Analysis and Modularity of Brain Functional Connectivity Networks: Searching for the Optimal Threshold published pages: 441, ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00441	Frontiers in Neuroscience 11	2020-01-15
2018	Anita C. Hansson, Gerhard GrÃ¼nder, Natalie Hirth, Hamid R. Noori, Rainer Spanagel, Wolfgang H. Sommer Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies published pages: , ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.09.010	Neuroscience & Biobehavioral Reviews	2020-01-15
2019	Silvia De Santis, Patrick Bach, Laura PÃ©rez-Cervera, Alejandro Cosa-Linan, Georg Weil, Sabine VollstÃ¤dt-Klein, Derik Hermann, Falk Kiefer, Peter Kirsch, Roberto Ciccocioppo, Wolfgang H. Sommer, Santiago Canals Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence published pages: , ISSN: 2168-622X, DOI: 10.1001/jamapsychiatry.2019.0318	JAMA Psychiatry	2020-01-15
2017	Silvia De Santis, David Moratal, Santiago Canals Radiomicrobiomics: Advancing Along the Gut-brain Axis Through Big Data Analysis published pages: , ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2017.11.055	Neuroscience	2020-01-15
2019	Patrick Bach, Georg Weil, Enrico Pompili, Sabine Hoffmann, Derik Hermann, Sabine VollstÃ¤dt-Klein, Karl Mann, Ursula Perez-Ramirez, David Moratal, Santiago Canals, Serdar M. Dursun, Andrew J. Greenshaw, Peter Kirsch, Falk Kiefer, Wolfgang H. Sommer Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone published pages: , ISSN: 1355-6215, DOI: 10.1111/adb.12717	Addiction Biology	2020-01-15
2018	Aref Pariz, Zahra G. Esfahani, Shervin S. Parsi, Alireza Valizadeh, Santiago Canals, Claudio R. Mirasso High frequency neurons determine effective connectivity in neuronal networks published pages: 349-359, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.11.014	NeuroImage 166	2020-01-15
2018	Hamid R. Noori, Lewis H. Mervin, Vahid Bokharaie, Ã–zlem Durmus, Lisamon Egenrieder, Stefan Fritze, Britta Gruhlke, Giulia Reinhardt, Hans-Hendrik Schabel, Sabine Staudenmaier, Nikos K. Logothetis, Andreas Bender, Rainer Spanagel Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07239-1	Nature Communications 9/1	2020-01-15

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