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OptoHear SIGNED

Cochlear Optogenetics for Auditory Research and Prosthetics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

OptoHear project word cloud

Explore the words cloud of the OptoHear project. It provides you a very rough idea of what is the project "OptoHear" about.

co poor cis encoded emitters light rodents enabled improvement chrs channels position frequency virus intensity multichannel dramatic demonstrated implants treatment coding optogenetics employed rodent promises implanted optical vs comprehension clinic behavioural limitation million causal optohear spiral proof cochlear hi overcome electric prevalence physiological mediated ray form expression time recorded impairment validate artificial confined axis independent disabling prepare expressing quality tool employ unprecedented evoked hearing 360 channelrhodopsin chr tomography ganglion neurons fundamental speech translation cochlea sensorineural optogenetic age sgns restoration worldwide suited people sound tens optimize stimulation resolution provides neuronal auditory

Project "OptoHear" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS Organization address address: Robert-Koch-Strasse 40 city: GOETTINGEN postcode: 37075 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.auditory-neuroscience.uni-goettingen.de/OptoHear.html
Total cost	2˙496˙405 €
EC max contribution	2˙496˙405 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-ADG
Funding Scheme	ERC-ADG
Starting year	2015
Duration (year-month-day)	from 2015-12-01 to 2020-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS Organization address address: Robert-Koch-Strasse 40 city: GOETTINGEN postcode: 37075 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GOETTINGEN)	coordinator	2˙496˙405.00

Map

Project objective

Disabling hearing impairment (HI) affects 360 million people worldwide and prevalence increases with age. So far, no causal treatment is available for its most common form, sensorineural HI. I propose to establish, characterize, and employ optogenetic stimulation of the cochlea, which provides unprecedented opportunities for auditory research and promises a fundamental advance of hearing restoration. Sound is encoded by spiral ganglion neurons (SGNs) with high frequency-, intensity-, and time-resolution. Hearing can be enabled via electric stimulation of SGNs, which is employed in current hearing restoration with cochlear implants (CIs) and also used in auditory research. CIs enable speech comprehension in most users, but the quality of ‘electric hearing’ is low, with poor frequency resolution. The goal of OptoHear is to overcome this fundamental limitation by increasing the number of independent coding channels via spatially confined optical stimulation of channelrhodopsin (ChR)-expressing SGNs by tens of light emitters along the cochlear axis (cochlear optogenetics). This promises a dramatic improvement in the frequency resolution of artificial sound coding. As proof of principle, we achieved virus-mediated expression of ChR in SGNs, recorded light-evoked auditory activity and demonstrated improved frequency resolution for optical vs. electric stimulation in rodents. We co-developed and implanted optical multichannel CIs and studied their position in the rodent cochlea using X-ray tomography. We will optimize the expression of best-suited ChRs in SGNs, establish multichannel optical stimulation, characterize neuronal responses to cochlear optogenetics along the auditory pathway by physiological and behavioural approaches, and employ cochlear optogenetics for fundamental auditory research. OptoHear will establish and use cochlear optogenetics as a research tool, validate its potential for research and hearing restoration, and prepare translation into the clinic.

Publications

List of publications.
year	authors and title	journal	last update
2018	Daniel Keppeler, Ricardo Martins Merino, David Lopez de la Morena, Burak Bali, Antoine Tarquin Huet, Anna Gehrt, Christian Wrobel, Swati Subramanian, Tobias Dombrowski, Fred Wolf, Vladan Rankovic, Andreas Neef, Tobias Moser Ultrafast optogenetic stimulation of the auditory pathway by targetingâ€optimized Chronos published pages: e99649, ISSN: 0261-4189, DOI: 10.15252/embj.201899649	The EMBO Journal 37/24	2019-08-29
2018	Mareike TÃ¶pperwien, Regine Gradl, Daniel Keppeler, Malte Vassholz, Alexander Meyer, Roland Hessler, Klaus Achterhold, Bernhard Gleich, Martin Dierolf, Franz Pfeiffer, Tobias Moser, Tim Salditt Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-23144-5	Scientific Reports 8/1	2019-07-05
2018	Thomas Mager, David Lopez de la Morena, Verena Senn, Johannes Schlotte, Anna DÂ´Errico, Katrin Feldbauer, Christian Wrobel, Sangyong Jung, Kai Bodensiek, Vladan Rankovic, Lorcan Browne, Antoine Huet, Josephine JÃ¼ttner, Phillip G. Wood, Johannes J. Letzkus, Tobias Moser, Ernst Bamberg High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04146-3	Nature Communications 9/1	2019-07-05
2019	Alexander Dieter, Carlos J. Duque-Afonso, Vladan Rankovic, Marcus Jeschke, Tobias Moser Near physiological spectral selectivity of cochlear optogenetics published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09980-7	Nature Communications 10/1	2019-08-05
2018	Christian Wrobel, Alexander Dieter, Antoine Huet, Daniel Keppeler, Carlos J. Duque-Afonso, Christian Vogl, Gerhard Hoch, Marcus Jeschke, Tobias Moser Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils published pages: eaao0540, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aao0540	Science Translational Medicine 10/449	2019-05-28

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