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miVaO SIGNED

Microbiota mediating Vagal communication in Obesity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 miVaO project word cloud

Explore the words cloud of the miVaO project. It provides you a very rough idea of what is the project "miVaO" about.

innervation    euproject    shift    situation    obesity    central    societal    axis    tissue    energy    lack    bacteria    brain    bacterial    mivao    suggests    discern    direct    preventive    enteroendocrine    context    gut    mediated    mediating    communication    afferents    microbiome    clinical    created    host    subsequent    indirectly    prevent    health    nonetheless    propel    indicate    modulating    players    neuroactive    gain    scientific    comorbidities    innervations    prevention    prevalence    preclinical    worldwide    highlights    strain    realization    function    white    hindering    applicability    constituted    gastrointestinal    mynewgut    envision    reached    unprecedented    regulating    adipose    combat    strategies    microbiota    attenuate    continue    vagal    public    modulated    promotion    homeostasis    influences    biobank    candidate    ultimate    afferent    intestinal    strains    fibres    indirect    human    play    metabolism    periphery    epidemic    disease    proportions    benefits    communicate   

Project "miVaO" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 158˙121.00

Map

 Project objective

Obesity and its comorbidities currently represent major societal and health challenges worldwide. Its prevalence has reached epidemic proportions and trends continue to rise. This situation highlights the need for more effective preventive measures. The realization that the gut microbiota could play a central role in human energy metabolism has constituted an unprecedented shift in the way we envision obesity management. Nonetheless, we still lack understanding of which the key gut microbiota players are and how they communicate with the host, thus hindering further advances in the design and clinical applicability of microbiome-based strategies to combat obesity. Preclinical studies indicate that gut microbiota impact on energy homeostasis by modulating gastrointestinal innervation function, including vagal afferent fibres, which are involved in regulating the gut-brain-periphery axis. Scientific evidence suggests that vagal afferent function may be directly affected by gut microbiota or indirectly by the enteroendocrine system, also modulated by gut microbiota. The aim of the miVaO (microbiota mediating Vagal communication in Obesity) proposal is to a gain greater understanding of how gut microbiota influences the gut-brain axis by modulating gut vagal innervations and the subsequent impact on energy homeostasis and, in particular, on white adipose tissue. To achieve this general aim, we propose using the intestinal human bacteria biobank created in the context of the EUproject MyNewGut by the host institution to: 1) identify bacterial strains with potential neuroactive properties; 2) discern between direct and indirect-enteroendocrine-mediated bacterial effects on vagal afferents and 3) identify the best candidate strain able to prevent or attenuate obesity by modulating vagal afferents. The ultimate goal of this proposal is to propel the development of microbiome-based strategies that bring societal benefits via disease prevention and public health promotion.

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The information about "MIVAO" are provided by the European Opendata Portal: CORDIS opendata.

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