CENTRE-PD
TWINNING for a Comprehensive Clinical Centre for the Diagnosis and Treatment of Parkinson's Disease
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the CENTRE-PD project. It provides you a very rough idea of what is the project "CENTRE-PD" about.
Project "CENTRE-PD" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITE DU LUXEMBOURG
Organization address contact info |
| Coordinator Country | Luxembourg [LU] |
| Project website | http://www.centre-pd.eu |
| Total cost | 1˙062˙500 € |
| EC max contribution | 1˙062˙500 € (100%) |
| Programme |
1. H2020-EU.4.b. (Twinning of research institutions) |
| Code Call | H2020-TWINN-2015 |
| Funding Scheme | CSA |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-03-01 to 2019-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITE DU LUXEMBOURG | LU (ESCH-SUR-ALZETTE) | coordinator | 500˙000.00 |
| 2 | EBERHARD KARLS UNIVERSITAET TUEBINGEN | DE (TUEBINGEN) | participant | 281˙250.00 |
| 3 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | participant | 281˙250.00 |
Map
Project objective
Unlike other EU member states, Luxembourg lacks a tradition for translation of fundamental research into clinical practice, which hampers health innovation and its adoption in cutting-edge medicine. During the last years, the Luxembourg Government made substantial efforts to position biomedicine as a key innovation driver. This highly successful biomedical initiative placed fundamental research on Parkinson’s disease (PD) in Luxembourg on an internationally competitive level, however, to realise the economic and health benefits for the population, closing the gap between basic science and clinical application is now a crucial challenge. CENTRE-PD aims at TWINNING the Universities of Oxford and Tübingen, two worldwide leading centres for PD, with the University of Luxembourg (UL) to establish a comprehensive clinical PD centre in Luxembourg. CENTRE-PD will build human and institutional capacity for an excellent centre for diagnosis and treatment of PD in Luxembourg on the one hand and will ensure sustainability and viability of the centre on the other hand. We expect to reach key deliverables in three areas: (i) building of new infrastructures at UL (including a prospective PD patient cohort and at-risk cohort, a brain bank, neuro-imaging and stem-cell platforms, a neuro-stimulation centre and gait laboratory), (ii) launching of joint research initiatives (harmonised clinical datasets and neuropathological validation, joint biomarker studies for early diagnosis and stratification of PD, compound screening campaings on patient-based cellular models, and joint studies on neuro-modulation), and (iii) engaging key stakeholders through clinical and public outreach programmes, training of clinical researchers and basic scientists, partnerships with industry and initiatives for patient involvement. The external excellent competence provided through TWINNING will strengthen the potential for future collaborations nationally and beyond borders, boosting research excellence.
Deliverables
| Implementation of a gait laboratory using telemetric assessments in Luxembourg | Documents, reports | 2019-09-13 11:09:58 |
| Definition of criteria for the recruitment of an at-risk-cohort in Luxembourg | Documents, reports | 2019-09-13 11:09:58 |
| Standardised protocols for iPSC-based models (reprogramming, maintenance, gene editing) | Documents, reports | 2019-09-13 11:09:58 |
| Working paper for management of the comprehensive clinical PD centre | Documents, reports | 2019-09-13 11:09:58 |
| Research and Industrial collaborations established | Documents, reports | 2019-09-13 11:09:59 |
| Common neuro-imaging platform multivariate feature discovery in PD | Documents, reports | 2019-09-13 11:09:58 |
| Evaluation procedures | Documents, reports | 2019-09-13 11:09:58 |
| Website/Intranet | Websites, patent fillings, videos etc. | 2019-09-13 11:09:57 |
| Movement disorders curriculum | Documents, reports | 2019-09-13 11:09:57 |
| Ethical approval for brain banking in Luxembourg | Documents, reports | 2019-09-13 11:09:57 |
| Comprehensive awareness programme plan | Documents, reports | 2019-09-13 11:09:57 |
Take a look to the deliverables list in detail: detailed list of CENTRE-PD deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Geraldine Hipp, Michel Vaillant, Nico J. Diederich, Kirsten Roomp, Venkata P. Satagopam, Peter Banda, Estelle Sandt, Kathleen Mommaerts, Sabine K. Schmitz, Laura Longhino, Alexandra Schweicher, Anne-Marie Hanff, Béatrice Nicolai, Pierre Kolber, Dorothea Reiter, Lukas Pavelka, Sylvia Binck, Claire Pauly, Lars Geffers, Fay Betsou, Manon Gantenbein, Jochen Klucken, Thomas Gasser, Michele T. Hu, Rudi Balling, Rejko Krüger The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2018.00326 |
Frontiers in Aging Neuroscience 10 | 2019-09-13 |
| 2018 |
S. B. Larsen, Z. Hanss, R. Krüger The genetic architecture of mitochondrial dysfunction in Parkinson’s disease published pages: 21-37, ISSN: 0302-766X, DOI: 10.1007/s00441-017-2768-8 |
Cell and Tissue Research 373/1 | 2019-09-13 |
| 2018 |
Jochen Klucken, Rejko Krüger, Peter Schmidt, Bastiaan R. Bloem Management of Parkinson’s Disease 20 Years from Now: Towards Digital Health Pathways published pages: S85-S94, ISSN: 1877-7171, DOI: 10.3233/jpd-181519 |
Journal of Parkinson\'s Disease 8/s1 | 2019-09-13 |
| 2017 |
Rejko Krüger, Paul Lingor, Triantafyllos Doskas, Johanna M. L. Henselmans, Erik H. Danielsen, Oriol de Fabregues, Alessandro Stefani, Sven-Christian Sensken, Juan Carlos Parra, Koray Onuk, Ashley Yegin, Angelo Antonini An Observational Study of the Effect of Levodopa–Carbidopa Intestinal Gel on Activities of Daily Living and Quality of Life in Advanced Parkinson’s Disease Patients published pages: 1741-1752, ISSN: 0741-238X, DOI: 10.1007/s12325-017-0571-2 |
Advances in Therapy 34/7 | 2019-09-13 |
| 2017 |
Cornelis Blauwendraat, Faraz Faghri, Lasse Pihlstrom, Joshua T. Geiger, Alexis Elbaz, Suzanne Lesage, Jean-Christophe Corvol, Patrick May, Aude Nicolas, Yevgeniya Abramzon, Natalie A. Murphy, J. Raphael Gibbs, Mina Ryten, Raffaele Ferrari, Jose Bras, Rita Guerreiro, Julie Williams, Rebecca Sims, Steven Lubbe, Dena G. Hernandez, Kin Y. Mok, Laurie Robak, Roy H. Campbell, Ekaterina Rogaeva, Bryan J. Traynor, Ruth Chia, Sun Ju Chung, John A. Hardy, Alexis Brice, Nicholas W. Wood, Henry Houlden, Joshua M. Shulman, Huw R. Morris, Thomas Gasser, Rejko Krüger, Peter Heutink, Manu Sharma, Javier Simón-Sánchez, Mike A. Nalls, Andrew B. Singleton, Sonja W. Scholz NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases published pages: 247.e9-247.e13, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2017.05.009 |
Neurobiology of Aging 57 | 2019-09-13 |
| 2016 |
W. Maetzler, R. Krüger, T. Müller, W. Oertel, P. Urban, T. Warnecke, J. Klucken Tragbare und aktiv vom Parkinson-Patienten genutzte Technologie im häuslichen Umfeld: Was bringt die Zukunft? published pages: S48-S51, ISSN: 0720-4299, DOI: 10.1055/s-0042-102786 |
Fortschritte der Neurologie · Psychiatrie 84/S 01 | 2019-09-13 |
| 2016 |
Daniel Weiss, Sonja Herrmann, Lisa Wang, Claudia Schulte, Kathrin Brockmann, Christian Plewnia, Thomas Gasser, Manu Sharma, Alireza Gharabaghi, Rejko Krüger Alpha-synuclein gene variants may predict neurostimulation outcome published pages: 601-603, ISSN: 0885-3185, DOI: 10.1002/mds.26558 |
Movement Disorders 31/4 | 2019-09-13 |
| 2017 |
Julia C Fitzgerald, Alexander Zimprich, Daniel A Carvajal Berrio, Kevin M Schindler, Brigitte Maurer, Claudia Schulte, Christine Bus, Anne-Kathrin Hauser, Manuela Kübler, Rahel Lewin, Dheeraj Reddy Bobbili, Lisa M Schwarz, Evangelia Vartholomaiou, Kathrin Brockmann, Richard Wüst, Johannes Madlung, Alfred Nordheim, Olaf Riess, L Miguel Martins, Enrico Glaab, Patrick May, Katja Schenke-Layland, Didier Picard, Manu Sharma, Thomas Gasser, Rejko Krüger Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson’s disease published pages: 2444-2459, ISSN: 0006-8950, DOI: 10.1093/brain/awx202 |
Brain 140/9 | 2019-09-13 |
| 2016 |
Richard Wüst, Brigitte Maurer, Kathrin Hauser, Dirk Woitalla, Manu Sharma, Rejko Krüger Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson\'s disease published pages: 217.e13-217.e15, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2015.11.025 |
Neurobiology of Aging 39 | 2019-09-13 |
| 2016 |
Michael Lawton, Meike Kasten, Margaret T. May, Brit Mollenhauer, Martina Schaumburg, Inga Liepelt-Scarfone, Walter Maetzler, Eva-Juliane Vollstedt, Michele T.M. Hu, Daniela Berg, Yoav Ben-Shlomo Validation of conversion between mini-mental state examination and montreal cognitive assessment published pages: 593-596, ISSN: 0885-3185, DOI: 10.1002/mds.26498 |
Movement Disorders 31/4 | 2019-09-13 |
| 2016 |
Marlieke Scholten, Rathinaswamy B. Govindan, Christoph Braun, Bastiaan R. Bloem, Christian Plewnia, Rejko Krüger, Alireza Gharabaghi, Daniel Weiss Cortical correlates of susceptibility to upper limb freezing in Parkinson’s disease published pages: 2386-2393, ISSN: 1388-2457, DOI: 10.1016/j.clinph.2016.01.028 |
Clinical Neurophysiology 127/6 | 2019-09-13 |
| 2017 |
Lisa Wang, Michael G. Heckman, Jan O. Aasly, Grazia Annesi, Maria Bozi, Sun Ju Chung, Carl Clarke, David Crosiers, Gertrud Eckstein, Gaetan Garraux, Georgios M. Hadjigeorgiou, Nobu Hattori, Beom Jeon, Yun J. Kim, Masato Kubo, Suzanne Lesage, Juei Jueng Lin, Timothy Lynch, Peter Lichtner, George D. Mellick, Vincent Mok, Karin E. Morrison, Aldo Quattrone, Wataru Satake, Peter A. Silburn, Leonidas Stefanis, Joanne D. Stockton, Eng King Tan, Tatsushi Toda, Alexis Brice, Christine Van Broeckhoven, Ryan J. Uitti, Karin Wirdefeldt, Zbigniew Wszolek, Georgia Xiromerisiou, Demetrius M. Maraganore, Thomas Gasser, Rejko Krüger, Matthew J. Farrer, Owen A. Ross, Manu Sharma Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson\'s disease: analysis of a large multicenter study published pages: 217.e1-217.e4, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2016.09.022 |
Neurobiology of Aging 49 | 2019-09-13 |
| 2017 |
Rejko Krüger, Jochen Klucken, Daniel Weiss, Lars Tönges, Pierre Kolber, Stefan Unterecker, Michael Lorrain, Horst Baas, Thomas Müller, Peter Riederer Classification of advanced stages of Parkinson’s disease: translation into stratified treatments published pages: 1015-1027, ISSN: 0300-9564, DOI: 10.1007/s00702-017-1707-x |
Journal of Neural Transmission 124/8 | 2019-09-13 |
| 2016 |
Stefanie Lerche, Sebastian Heinzel, Guido W. Alves, Paolo Barone, Stefanie Behnke, Yoav Ben-Shlomo, Henk Berendse, Bastiaan R. Bloem, David Burn, Richard Dodel, Donald G. Grosset, Geraldine Hipp, Michele T. Hu, Meike Kasten, Rejko Krüger, Inga Liepelt-Scarfone, Walter Maetzler, Marcello Moccia, Brit Mollenhauer, Wolfgang Oertel, Benjamin Roeben, Uwe Walter, Karin Wirdefeldt, Daniela Berg Aiming for Study Comparability in Parkinson\'s Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2016.00121 |
Frontiers in Aging Neuroscience 8 | 2019-09-13 |
| 2016 |
Nicolas Casadei, Poonam Sood, Thomas Ulrich, Petra Fallier-Becker, Nicole Kieper, Stefan Helling, Caroline May, Enrico Glaab, Jing Chen, Silke Nuber, Katrin Marcus, Doron Rapaport, Thomas Ott, Olaf Riess, Rejko Krüger, Julia C. Fitzgerald Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2 published pages: 459-471, ISSN: 0964-6906, DOI: 10.1093/hmg/ddv485 |
Human Molecular Genetics 25/3 | 2019-09-13 |
| 2016 |
Sebastian Heinzel, Benjamin Roeben, Yoav Ben-Shlomo, Stefanie Lerche, Guido Alves, Paolo Barone, Stefanie Behnke, Henk W. Berendse, Bastiaan R. Bloem, David Burn, Richard Dodel, Donald G. Grosset, Michele Hu, Meike Kasten, Rejko Krüger, Marcello Moccia, Brit Mollenhauer, Wolfgang Oertel, Ulrike Suenkel, Uwe Walter, Karin Wirdefeldt, Inga Liepelt-Scarfone, Walter Maetzler, Daniela Berg Prodromal Markers in Parkinson’s Disease: Limitations in Longitudinal Studies and Lessons Learned published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2016.00147 |
Frontiers in Aging Neuroscience 8 | 2019-09-13 |
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