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PolyDrug Discovery

Discovery of anticancer polymeric drugs that mimic the action of TRAIL

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PolyDrug Discovery project word cloud

Explore the words cloud of the PolyDrug Discovery project. It provides you a very rough idea of what is the project "PolyDrug Discovery" about.

action innovative binding realizing cell trail peptides discovery replacements treatment scope hit prevent throughput 1982 polymeric screening demanding chemistry company anticancer necrosis death mabs output modeling apoptosis efforts human library wp optimization receptor macromolecular breast affinity start interferons biopharmaceuticals preclinical cytokines preparation ligand combinatorial full approval polydrugs capacity multivalent clinical drug antibodies prepared wp2 insulin polymer recombinant storage monoclonal greatest display polymers epitopes polydrug dr5 mimics tumor cancer followed wp1 modern mainstream hypothesize inducing

Project "PolyDrug Discovery" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://www.gormleylab.com
Total cost	173˙857 €
EC max contribution	173˙857 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2018-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	173˙857.00

Map

Project objective

Biopharmaceuticals such as monoclonal antibodies (mAbs) and interferons/cytokines have become mainstream since the approval of recombinant human insulin in 1982. However, many challenges such as production costs, output capacity and demanding storage conditions prevent them from realizing their full potential. Therefore, the objective of this action is to develop a polymeric drug (PolyDrug) that mimics the activity of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) for the treatment of breast cancer. To do this, multivalent polymers that display peptides (binding epitopes) with high affinity for death receptor 5 (DR5) will be prepared in high-throughput using combinatorial polymer chemistry. Then, the modern drug discovery process will be applied to identify/develop PolyDrugs with the greatest anticancer potential. This includes library preparation in Work Package 1 (WP1), high-throughput screening and hit to lead in WP2, and lead optimization through cell studies and macromolecular modeling in WP 3. Beyond this scope of this action, these efforts will be followed by preclinical and clinical development within a start-up PolyDrug discovery company. With this innovative PolyDrug discovery process, I hypothesize that I will be able to develop polymeric replacements for current biopharmaceuticals including TRAIL.

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The information about "POLYDRUG DISCOVERY" are provided by the European Opendata Portal: CORDIS opendata.