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microCardio SIGNED

Functional high-throughput analysis of the role of microRNAs in cardiac ischemia-reperfusion injury

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

microCardio project word cloud

Explore the words cloud of the microCardio project. It provides you a very rough idea of what is the project "microCardio" about.

unappreciated resistance uses deep vitro pathologies underlying genome irreversible counteract tissues oxygen micrornas infarction identification combination mortality causing settings myocardial clinical experimental characterise morbidity prolonged therapeutic intervene damage disease implications reveal injury characterised few vivo supply unravel ischemia tissue reperfusion mimicking microrna innovative deprivation expression gain network cardiac cardiomyocytes critical libraries shown transversal sequencing implicated heart aggravated computational functional screenings insufficient previously mechanisms blood throughput susceptibility molecular intervention function entail missing potentially characterisation

Project "microCardio" data sheet

The following table provides information about the project.

Coordinator	CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO Organization address address: UNIVERSIDADE DE COIMBRA, LARGO DE POMBAL city: COIMBRA postcode: 3004 517 website: www.cnbc.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Project website	http://www.cnbc.pt/research/department_group_show.asp
Total cost	148˙635 €
EC max contribution	148˙635 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2018-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO Organization address address: UNIVERSIDADE DE COIMBRA, LARGO DE POMBAL city: COIMBRA postcode: 3004 517 website: www.cnbc.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (COIMBRA)	coordinator	148˙635.00

Map

Project objective

Ischemia-reperfusion injury is a major cause of morbidity and mortality transversal to different clinical settings and pathologies, including myocardial infarction. Ischemia is characterised by insufficient supply of blood to tissues causing tissue oxygen deprivation. Importantly, damage by prolonged ischemia is further aggravated by reperfusion, leading to irreversible tissue damage. Identifying and understanding the factors contributing to ischemia-reperfusion injury is essential to counteract the irreversible damage and to potentially develop novel therapeutic approaches to intervene in myocardial infarction. Recent studies have shown that microRNAs control various aspects of heart disease, including ischemia-reperfusion injury. Although a few microRNAs have already been implicated in this process, a comprehensive analysis of the functional role of microRNAs in cardiac ischemia-reperfusion injury is still missing.

The main goal of this project is to identify microRNAs controlling the resistance/susceptibility of cardiomyocytes to ischemia-reperfusion injury and characterise the molecular mechanisms underlying their function. This will be achieved through the combination of gain- and loss-of-function high-throughput screenings using genome-wide microRNA libraries, and deep-sequencing analysis of microRNA expression in conditions mimicking ischemia and ischemia-reperfusion in vitro and in vivo. The identification and characterisation of the molecular targets of the selected microRNAs will entail a combination of computational and experimental approaches

This project uses innovative experimental approaches and will unravel a previously unappreciated network of microRNAs and microRNA targets critical to ischemia-reperfusion injury, which may reveal novel opportunities for therapeutic intervention, with important clinical implications.

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The information about "MICROCARDIO" are provided by the European Opendata Portal: CORDIS opendata.