ICARO SIGNED
Colloidal Inorganic Nanostructures for Radiotherapy and Chemotherapy
Total Cost €
0EC-Contrib. €
0Partnership
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0ICARO project word cloud
Explore the words cloud of the ICARO project. It provides you a very rough idea of what is the project "ICARO" about.
Project "ICARO" data sheet
The following table provides information about the project.
| Coordinator |
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Total cost | 1˙160˙000 € |
| EC max contribution | 1˙160˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-03-01 to 2020-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA | IT (GENOVA) | coordinator | 1˙160˙000.00 |
Map
Project objective
Radio and chemotherapy are the major clinical treatments for cancer. However these treatments lack cell specificity and can have severe side effects against healthy cells, especially when used in combination. My goal is to develop a nanocrystal (NC) platform to merge radio and chemotherapy into a single entity that is more specific towards tumor cells. To achieve ICARO’s goal, three main objectives will be pursued. The first objective is to introduce post-synthesis reactions, namely cation exchange (CE) and intercalation (INT) reactions, as new protocols to replace or intercalate cations that are useful as radionuclides within the crystal lattice of water-soluble NCs. Our goal is to establish protocols for the preparation of radiolabelled-NCs that will be easily translated to the medical practice for radiotherapy. This requires CE/INT reactions that occur in aqueous media, possibly with NCs prefunctionalized with specific recognition molecules to achieve targeted radiotherapy. To minimize the radio exposure of the operator, CE/INT protocols will be carried out as the last step of NC preparation. The second objective of ICARO will be to explore in situ CE/INT reactions with NCs entrapped in a matrix that simulates the tumor mass. By first located NCs at the tumor and then let the CE/INT to occur, enhance therapeutic effect is expected. The third objective of ICARO will be to develop heterostructures to combine radio and chemotherapy. They will include at least one semiconductor NC on which to perform radiolabelling protocols and one portion made of a superparamagnetic (SP) NC for magnetically triggered drug release. With respect to magnetic hyperthermia, which exploits SP-NCs to produce bulk heat (>46°C) at the tumor, the local heat effect generated at the surface of SP-NCs will enable drug release using a lower dose of magnetic material. Finally, new types of heterostructures combining radio and chemotherapy will be tested, for the first time, in preclinical trials.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Aidin Lak, Dina Niculaes, George C. Anyfantis, Giovanni Bertoni, Markus J. Barthel, Sergio Marras, Marco Cassani, Simone Nitti, Athanassia Athanassiou, Cinzia Giannini, Teresa Pellegrino Facile transformation of FeO/Fe3O4 core-shell nanocubes to Fe3O4 via magnetic stimulation published pages: , ISSN: 2045-2322, DOI: 10.1038/srep33295 |
Scientific Reports 6/1 | 2019-07-22 |
| 2017 |
Maria Elena Materia, Manuel Pernia Leal, Marco Scotto, Preethi Bala Balakrishnan, Sahitya Avugadda Kumar, MarÃa Luisa GarcÃa-MartÃn, Bruce E Cohen, Emory M. Chan, Teresa Pellegrino Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools published pages: , ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.7b00432 |
Bioconjugate Chemistry | 2019-07-22 |
| 2017 |
Alessandra Quarta, Marina Rodio, Marco Cassani, Giuseppe Gigli, Teresa Pellegrino, Loretta L. del Mercato Multilayered Magnetic Nanobeads for the Delivery of Peptides Molecules Triggered by Intracellular Proteases published pages: 35095-35104, ISSN: 1944-8244, DOI: 10.1021/acsami.7b05709 |
ACS Applied Materials & Interfaces 9/40 | 2019-07-22 |
| 2018 |
Preethi Bala Balakrishnan, Lorenza Gardella, Mahdi Forouharshad, Teresa Pellegrino, Orietta Monticelli Star poly(ε-caprolactone)-based electrospun fibers as biocompatible scaffold for doxorubicin with prolonged drug release activity published pages: 488-496, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2017.11.014 |
Colloids and Surfaces B: Biointerfaces 161 | 2019-07-22 |
| 2017 |
Silvia Dante, Alessia Petrelli, Enrica Maria Petrini, Roberto Marotta, Alessandro Maccione, Alessandro Alabastri, Alessandra Quarta, Francesco De Donato, Tiziana Ravasenga, Ayyappan Sathya, Roberto Cingolani, Remo Proietti Zaccaria, Luca Berdondini, Andrea Barberis, Teresa Pellegrino Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Charge published pages: 6630-6640, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b00397 |
ACS Nano 11/7 | 2019-07-22 |
| 2017 |
P. Guardia, S. Nitti, M. E. Materia, G. Pugliese, N. Yaacoub, J.-M. Greneche, C. Lefevre, L. Manna, T. Pellegrino Gold–iron oxide dimers for magnetic hyperthermia: the key role of chloride ions in the synthesis to boost the heating efficiency published pages: 4587-4594, ISSN: 2050-7518, DOI: 10.1039/c7tb00968b |
J. Mater. Chem. B 5/24 | 2019-07-22 |
| 2016 |
Sandeep Ghosh, Tommaso Avellini, Alessia Petrelli, Ilka Kriegel, Roberto Gaspari, Guilherme Almeida, Giovanni Bertoni, Andrea Cavalli, Francesco Scotognella, Teresa Pellegrino, Liberato Manna Colloidal CuFeS 2 Nanocrystals: Intermediate Fe d-Band Leads to High Photothermal Conversion Efficiency published pages: 4848-4858, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.6b02192 |
Chemistry of Materials 28/13 | 2019-07-22 |
| 2016 |
Dina Niculaes, Aidin Lak, George C. Anyfantis, Sergio Marras, Oliver Laslett, Sahitya K. Avugadda, Marco Cassani, David Serantes, Ondrej Hovorka, Roy Chantrell, Teresa Pellegrino Asymmetric Assembling of Iron Oxide Nanocubes for Improving Magnetic Hyperthermia Performance published pages: 12121-12133, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b05182 |
ACS Nano 11/12 | 2019-07-22 |
| 2018 |
Hamilton Kakwere, Maria Elena Materia, Alberto Curcio, Mirko Prato, Ayyappan Sathya, Simone Nitti, Teresa Pellegrino Dually responsive gold–iron oxide heterodimers: merging stimuli-responsive surface properties with intrinsic inorganic material features published pages: 3930-3944, ISSN: 2040-3364, DOI: 10.1039/C7NR06726G |
Nanoscale 10/8 | 2019-07-22 |
| 2017 |
D. Cabrera, A. Lak, T. Yoshida, M. E. Materia, D. Ortega, F. Ludwig, P. Guardia, A. Sathya, T. Pellegrino, F. J. Teran Unraveling viscosity effects on the hysteresis losses of magnetic nanocubes published pages: 5094-5101, ISSN: 2040-3364, DOI: 10.1039/C7NR00810D |
Nanoscale 9/16 | 2019-07-22 |
| 2018 |
Binh T. Mai, Soraia Fernandes, Preethi B. Balakrishnan, Teresa Pellegrino Nanosystems Based on Magnetic Nanoparticles and Thermo- or pH-Responsive Polymers: An Update and Future Perspectives published pages: 999-1013, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.7b00549 |
Accounts of Chemical Research 51/5 | 2019-07-22 |
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