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Integrative omics of heart failure to inform discovery of novel drug targets and clinical biomarkers

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Project "inHForm" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: Lund
postcode: 22100
website: www.lu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://portal.research.lu.se/portal/en/persons/gustav-smith
 Total cost 1˙496˙625 €
 EC max contribution 1˙496˙625 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (Lund) coordinator 1˙496˙625.00

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 Project objective

Heart failure is a leading cause of morbidity and mortality in the aging European populations. It is the end-stage of myocardial and valvular disease, arising from loss of viable or functional muscle cells in the heart. Therapy is complicated by the multitude of causes and comorbidities of heart failure. New therapeutic targets and clinical biomarkers to individually tailor therapy (‘precision medicine’) are greatly needed. This research program aims to realize the promise of precision medicine by applying an integrated proteomic, genomic and epidemiological approach to the underlying causes, mechanisms and consequences for heart failure. The program builds on unique Swedish nation-wide disease registers and large biobanks, the translational research profile of the investigator and experience in genomics, epidemiology and proteomics. The program includes five work packages: (1) comprehensive plasma protein profiling through a discovery pipeline including novel microarray-based methods and mass spectrometry in a population-based cohort of 6000 subjects and clinical cases to identify subjects at risk for heart disease (2) assessment of heritable components to outcomes in heart disease using nation-wide Swedish registers (3) genome-wide discovery of variants associated with risk of and outcomes in heart disease as well as endophenotypes for cardiac structure and function, using resequencing and DNA microarrays in large population-based cohorts including >70,000 subjects from three generations (4) expression profiling in human heart samples and a novel human cardiomyocyte strain assay to translate genomic and proteomic findings to understanding of pathophysiological mechanisms (5) evaluate the clinical importance of plasma proteins and genetic variants in >3000 clinical cases. This research program is anticipated to result in new insights into the pathophysiology of heart failure and discovery of drug targets and clinical biomarkers.

 Publications

year authors and title journal last update
List of publications.
2018 Yan Borné, Klas Gränsbo, Jan Nilsson, Olle Melander, Marju Orho-Melander, J. Gustav Smith, Gunnar Engström
Vascular Endothelial Growth Factor D, Pulmonary Congestion, and Incidence of Heart Failure
published pages: 580-582, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2017.11.058
Journal of the American College of Cardiology 71/5 2019-04-18
2017 Andreas Martinsson, Xinjun Li, Bengt Zöller, Pontus Andell, Charlotte Andersson, Kristina Sundquist, J. Gustav Smith
Familial Aggregation of Aortic Valvular Stenosis
published pages: , ISSN: 1942-3268, DOI: 10.1161/CIRCGENETICS.117.001742
Circulation: Cardiovascular Genetics 10/6 2019-04-18
2016 J. Gustav Smith, Janine F. Felix, Alanna C. Morrison, Andreas Kalogeropoulos, Stella Trompet, Jemma B. Wilk, Olof Gidlöf, Xinchen Wang, Michael Morley, Michael Mendelson, Roby Joehanes, Symen Ligthart, Xiaoyin Shan, Joshua C. Bis, Ying A. Wang, Marketa Sjögren, Julius Ngwa, Jeffrey Brandimarto, David J. Stott, David Aguilar, Kenneth M. Rice, Howard D. Sesso, Serkalem Demissie, Brendan M. Buckley, Kent D. Taylor, Ian Ford, Chen Yao, Chunyu Liu, Nona Sotoodehnia, Pim van der Harst, Bruno H. Ch. Stricker, Stephen B. Kritchevsky, Yongmei Liu, J. Michael Gaziano, Albert Hofman, Christine S. Moravec, André G. Uitterlinden, Manolis Kellis, Joyce B. van Meurs, Kenneth B. Margulies, Abbas Dehghan, Daniel Levy, Björn Olde, Bruce M. Psaty, L. Adrienne Cupples, J. Wouter Jukema, Luc Djousse, Oscar H. Franco, Eric Boerwinkle, Laurie A. Boyer, Christopher Newton-Cheh, Javed Butler, Ramachandran S. Vasan, Thomas P. Cappola, Nicholas L. Smith
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure
published pages: e1006034, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1006034
PLOS Genetics 12/5 2019-04-18
2018 Carolina Roselli, Mark D. Chaffin, Lu-Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, Christine M. Albert, Peter Almgren, Alvaro Alonso, Christopher D. Anderson, Krishna G. Aragam, Dan E. Arking, John Barnard, Traci M. Bartz, Emelia J. Benjamin, Nathan A. Bihlmeyer, Joshua C. Bis, Heather L. Bloom, Eric Boerwinkle, Erwin B. Bottinger, Jennifer A. Brody, Hugh Calkins, Archie Campbell, Thomas P. Cappola, John Carlquist, Daniel I. Chasman, Lin Y. Chen, Yii-Der Ida Chen, Eue-Keun Choi, Seung Hoan Choi, Ingrid E. Christophersen, Mina K. Chung, John W. Cole, David Conen, James Cook, Harry J. Crijns, Michael J. Cutler, Scott M. Damrauer, Brian R. Daniels, Dawood Darbar, Graciela Delgado, Joshua C. Denny, Martin Dichgans, Marcus Dörr, Elton A. Dudink, Samuel C. Dudley, Nada Esa, Tonu Esko, Markku Eskola, Diane Fatkin, Stephan B. Felix, Ian Ford, Oscar H. Franco, Bastiaan Geelhoed, Raji P. Grewal, Vilmundur Gudnason, Xiuqing Guo, Namrata Gupta, Stefan Gustafsson, Rebecca Gutmann, Anders Hamsten, Tamara B. Harris, Caroline Hayward, Susan R. Heckbert, Jussi Hernesniemi, Lynne J. Hocking, Albert Hofman, Andrea R. V. R. Horimoto, Jie Huang, Paul L. Huang, Jennifer Huffman, Erik Ingelsson, Esra Gucuk Ipek, Kaoru Ito, Jordi Jimenez-Conde, Renee Johnson, J. Wouter Jukema, Stefan Kääb, Mika Kähönen, Yoichiro Kamatani, John P. Kane, Adnan Kastrati, Sekar Kathiresan, Petra Katschnig-Winter, Maryam Kavousi, Thorsten Kessler, Bas L. Kietselaer, Paulus Kirchhof, Marcus E. Kleber, Stacey Knight, Jose E. Krieger, Michiaki Kubo, Lenore J. Launer, Jari Laurikka, Terho Lehtimäki, Kirsten Leineweber, Rozenn N. Lemaitre, Man Li, Hong Euy Lim, Henry J. Lin, Honghuang Lin, Lars Lind, Cecilia M. Lindgren, Marja-Liisa Lokki, Barry London, Ruth J. F. Loos, Siew-Kee Low, Yingchang Lu, Leo-Pekka Lyytikäinen, Peter W. Macfarlane, Patrik K. Magnusson, Anubha Mahajan, Rainer Malik, Alfredo J. Mansur, Gregory M. Marcus, Lauren Margolin, Kenneth B. Margulies, Winfried März, David D. McManus, Olle Melander, Sanghamitra Mohanty, Jay A. Montgomery, Michael P. Morley, Andrew P. Morris, Martina Müller-Nurasyid, Andrea Natale, Saman Nazarian, Benjamin Neumann, Christopher Newton-Cheh, Maartje N. Niemeijer, Kjell Nikus, Peter Nilsson, Raymond Noordam, Heidi Oellers, Morten S. Olesen, Marju Orho-Melander, Sandosh Padmanabhan, Hui-Nam Pak, Guillaume Paré, Nancy L. Pedersen, Joanna Pera, Alexandre Pereira, David Porteous, Bruce M. Psaty, Sara L. Pulit, Clive R. Pullinger, Daniel J. Rader, Lena Refsgaard, Marta Ribasés, Paul M. Ridker, Michiel Rienstra, Lorenz Risch, Dan M. Roden, Jonathan Rosand, Michael A. Rosenberg, Natalia Rost, Jerome I. Rotter, Samir Saba, Roopinder K. Sandhu, Renate B. Schnabel, Katharina Schramm, Heribert Schunkert, Claudia Schurman, Stuart A. Scott, Ilkka Seppälä, Christian Shaffer, Svati Shah, Alaa A. Shalaby, Jaemin Shim, M. Benjamin Shoemaker, Joylene E. Siland, Juha Sinisalo, Moritz F. Sinner, Agnieszka Slowik, Albert V. Smith, Blair H. Smith, J. Gustav Smith, Jonathan D. Smith, Nicholas L. Smith, Elsayed Z. Soliman, Nona Sotoodehnia, Bruno H. Stricker, Albert Sun, Han Sun, Jesper H. Svendsen, Toshihiro Tanaka, Kahraman Tanriverdi, Kent D. Taylor, Maris Teder-Laving, Alexander Teumer, Sébastien Thériault, Stella Trompet, Nathan R. Tucker, Arnljot Tveit, Andre G. Uitterlinden, Pim Van Der Harst, Isabelle C. Van Gelder, David R. Van Wagoner, Niek Verweij, Efthymia Vlachopoulou, Uwe Völker, Biqi Wang, Peter E. Weeke, Bob Weijs, Raul Weiss, Stefan Weiss, Quinn S. Wells, Kerri L. Wiggins, Jorge A. Wong, Daniel Woo, Bradford B. Worrall, Pil-Sung Yang, Jie Yao, Zachary T. Yoneda, Tanja Zeller, Lingyao Zeng, Steven A. Lubitz, Kathryn L. Lunetta, Patrick T. Ellinor
Multi-ethnic genome-wide association study for atrial fibrillation
published pages: 1225-1233, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0133-9
Nature Genetics 50/9 2019-04-18
2018 Grunde Gjesdal, Oscar Ö. Braun, J. Gustav Smith, Fredrik Scherstén, Patrik Tydén
Blood lactate is a predictor of short-term mortality in patients with myocardial infarction complicated by heart failure but without cardiogenic shock
published pages: , ISSN: 1471-2261, DOI: 10.1186/s12872-018-0744-1
BMC Cardiovascular Disorders 18/1 2019-04-18
2017 Philipp S. Wild, Janine F. Felix, Arne Schillert, Alexander Teumer, Ming-Huei Chen, Maarten J.G. Leening, Uwe Völker, Vera Großmann, Jennifer A. Brody, Marguerite R. Irvin, Sanjiv J. Shah, Setia Pramana, Wolfgang Lieb, Reinhold Schmidt, Alice V. Stanton, Dörthe Malzahn, Albert Vernon Smith, Johan Sundström, Cosetta Minelli, Daniela Ruggiero, Leo-Pekka Lyytikäinen, Daniel Tiller, J. Gustav Smith, Claire Monnereau, Marco R. Di Tullio, Solomon K. Musani, Alanna C. Morrison, Tune H. Pers, Michael Morley, Marcus E. Kleber, Jayashri Aragam, Emelia J. Benjamin, Joshua C. Bis, Egbert Bisping, Ulrich Broeckel, Susan Cheng, Jaap W. Deckers, Fabiola Del Greco M, Frank Edelmann, Myriam Fornage, Lude Franke, Nele Friedrich, Tamara B. Harris, Edith Hofer, Albert Hofman, Jie Huang, Alun D. Hughes, Mika Kähönen, KNHI investigators, Jochen Kruppa, Karl J. Lackner, Lars Lannfelt, Rafael Laskowski, Lenore J. Launer, Margrét Leosdottir, Honghuang Lin, Cecilia M. Lindgren, Christina Loley, Calum A. MacRae, Deborah Mascalzoni, Jamil Mayet, Daniel Medenwald, Andrew P. Morris, Christian Müller, Martina Müller-Nurasyid, Stefania Nappo, Peter M. Nilsson, Sebastian Nuding, Teresa Nutile, Annette Peters, Arne Pfeufer, Diana Pietzner, Peter P. Pramstaller, Olli T. Raitakari, Kenneth M. Rice, Fernando Rivadeneira, Jerome I. Rotter, Saku T. Ruohonen, Ralph L. Sacco, Tandaw E. Samdarshi, Helena Schmidt, Andrew S.P. Sharp, Denis C. Shields, Rossella Sorice, Nona Sotoodehnia, Bruno H. Stricker, Praveen Surendran, Simon Thom, Anna M. Töglhofer, André G. Uitterlinden, Rolf Wachter, Henry Völzke, Andreas Ziegler, Thomas Münzel, Winfried März, Thomas P. Cappola, Joel N. Hirschhorn, Gary F. Mitchell, Nicholas L. Smith, Ervin R. Fox, Nicole D. Dueker, Vincent W.V. Jaddoe, Olle Melander, Martin Russ, Terho Lehtimäki, Marina Ciullo, Andrew A. Hicks, Lars Lind, Vilmundur Gudnason, Burkert Pieske, Anthony J. Barron, Robert Zweiker, Heribert Schunkert, Erik Ingelsson, Kiang Liu, Donna K. Arnett, Bruce M. Psaty, Stefan Blankenberg, Martin G. Larson, Stephan B. Felix, Oscar H. Franco, Tanja Zeller, Ramachandran S. Vasan, Marcus Dörr
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function
published pages: 1798-1812, ISSN: 0021-9738, DOI: 10.1172/JCI84840
Journal of Clinical Investigation 127/5 2019-04-18
2018 Mark D. Benson, Qiong Yang, Debby Ngo, Yineng Zhu, Dongxiao Shen, Laurie A. Farrell, Sumita Sinha, Michelle J. Keyes, Ramachandran S. Vasan, Martin G. Larson, J. Gustav Smith, Thomas J. Wang, Robert E. Gerszten
Genetic Architecture of the Cardiovascular Risk Proteome
published pages: 1158-1172, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.117.029536
Circulation 137/11 2019-04-18
2017 Pontus Andell, Xinjun Li, Andreas Martinsson, Charlotte Andersson, Martin Stagmo, Bengt Zöller, Kristina Sundquist, J Gustav Smith
Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study
published pages: 1696-1703, ISSN: 1355-6037, DOI: 10.1136/heartjnl-2016-310894
Heart 103/21 2019-04-18
2018 Andreas Martinsson, Petter Oest, Maj-Britt Wiborg, Öyvind Reitan, J. Gustav Smith
Longitudinal evaluation of ventricular ejection fraction and NT-proBNP across heart failure subgroups
published pages: 205-210, ISSN: 1401-7431, DOI: 10.1080/14017431.2018.1461920
Scandinavian Cardiovascular Journal 52/4 2019-04-18
2017 Stephen Zewinger, Marcus E Kleber, Vinicius Tragante, Raymond O McCubrey, Amand F Schmidt, Kenan Direk, Ulrich Laufs, Christian Werner, Wolfgang Koenig, Dietrich Rothenbacher, Ute Mons, Lutz P Breitling, Herrmann Brenner, Richard T Jennings, Ioannis Petrakis, Sarah Triem, Mira Klug, Alexandra Filips, Stefan Blankenberg, Christoph Waldeyer, Christoph Sinning, Renate B Schnabel, Karl J Lackner, Efthymia Vlachopoulou, Ottar Nygård, Gard Frodahl Tveitevåg Svingen, Eva Ringdal Pedersen, Grethe S Tell, Juha Sinisalo, Markku S Nieminen, Reijo Laaksonen, Stella Trompet, Roelof A J Smit, Naveed Sattar, J Wouter Jukema, Heinrich V Groesdonk, Graciela Delgado, Tatjana Stojakovic, Anna P Pilbrow, Vicky A Cameron, A Mark Richards, Robert N Doughty, Yan Gong, Rhonda Cooper-DeHoff, Julie Johnson, Markus Scholz, Frank Beutner, Joachim Thiery, J Gustav Smith, Ragnar O Vilmundarson, Ruth McPherson, Alexandre F R Stewart, Sharon Cresci, Petra A Lenzini, John A Spertus, Oliviero Olivieri, Domenico Girelli, Nicola I Martinelli, Andreas Leiherer, Christoph H Saely, Heinz Drexel, Axel Mündlein, Peter S Braund, Christopher P Nelson, Nilesh J Samani, Daniel Kofink, Imo E Hoefer, Gerard Pasterkamp, Arshed A Quyyumi, Yi-An Ko, Jaana A Hartiala, Hooman Allayee, W H Wilson Tang, Stanley L Hazen, Niclas Eriksson, Claes Held, Emil Hagström, Lars Wallentin, Axel Åkerblom, Agneta Siegbahn, Igor Karp, Christopher Labos, Louise Pilote, James C Engert, James M Brophy, George Thanassoulis, Peter Bogaty, Wojciech Szczeklik, Marcin Kaczor, Marek Sanak, Salim S Virani, Christie M Ballantyne, Vei-Vei Lee, Eric Boerwinkle, Michael V Holmes, Benjamin D Horne, Aroon Hingorani, Folkert W Asselbergs, Riyaz S Patel, Bernhard K Krämer, Hubert Scharnagl, Danilo Fliser, Winfried März, Thimoteus Speer
Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study
published pages: 534-543, ISSN: 2213-8587, DOI: 10.1016/S2213-8587(17)30096-7
The Lancet Diabetes & Endocrinology 5/7 2019-04-18
2017 Ihdina Sukma Dewi, Olof Gidlöf, Zsuzsanna Hollander, Karen K. Lam, Mark D. Benson, Oscar O. Braun, Johan Nilsson, Scott J. Tebbutt, Raymond T. Ng, Jenny Öhman, Bruce M. McManus, J. Gustav Smith
Immunological Serum Protein Profiles for Noninvasive Detection of Acute Cellular Rejection After Heart Transplantation
published pages: 2946-2947, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2017.10.012
Journal of the American College of Cardiology 70/23 2019-04-18
2017 Ingrid E Christophersen, Michiel Rienstra, Carolina Roselli, Xiaoyan Yin, Bastiaan Geelhoed, John Barnard, Honghuang Lin, Dan E Arking, Albert V Smith, Christine M Albert, Mark Chaffin, Nathan R Tucker, Molong Li, Derek Klarin, Nathan A Bihlmeyer, Siew-Kee Low, Peter E Weeke, Martina Müller-Nurasyid, J Gustav Smith, Jennifer A Brody, Maartje N Niemeijer, Marcus Dörr, Stella Trompet, Jennifer Huffman, Stefan Gustafsson, Claudia Schurmann, Marcus E Kleber, Leo-Pekka Lyytikäinen, Ilkka Seppälä, Rainer Malik, Andrea R V R Horimoto, Marco Perez, Juha Sinisalo, Stefanie Aeschbacher, Sébastien Thériault, Jie Yao, Farid Radmanesh, Stefan Weiss, Alexander Teumer, Seung Hoan Choi, Lu-Chen Weng, Sebastian Clauss, Rajat Deo, Daniel J Rader, Svati H Shah, Albert Sun, Jemma C Hopewell, Stephanie Debette, Ganesh Chauhan, Qiong Yang, Bradford B Worrall, Guillaume Paré, Yoichiro Kamatani, Yanick P Hagemeijer, Niek Verweij, Joylene E Siland, Michiaki Kubo, Jonathan D Smith, David R Van Wagoner, Joshua C Bis, Siegfried Perz, Bruce M Psaty, Paul M Ridker, Jared W Magnani, Tamara B Harris, Lenore J Launer, M Benjamin Shoemaker, Sandosh Padmanabhan, Jeffrey Haessler, Traci M Bartz, Melanie Waldenberger, Peter Lichtner, Marina Arendt, Jose E Krieger, Mika Kähönen, Lorenz Risch, Alfredo J Mansur, Annette Peters, Blair H Smith, Lars Lind, Stuart A Scott, Yingchang Lu, Erwin B Bottinger, Jussi Hernesniemi, Cecilia M Lindgren, Jorge A Wong, Jie Huang, Markku Eskola, Andrew P Morris, Ian Ford, Alex P Reiner, Graciela Delgado, Lin Y Chen, Yii-Der Ida Chen, Roopinder K Sandhu, Man Li, Eric Boerwinkle, Lewin Eisele, Lars Lannfelt, Natalia Rost, Christopher D Anderson, Kent D Taylor, Archie Campbell, Patrik K Magnusson, David Porteous, Lynne J Hocking, Efthymia Vlachopoulou, Nancy L Pedersen, Kjell Nikus, Marju Orho-Melander, Anders Hamsten, Jan Heeringa, Joshua C Denny, Jennifer Kriebel, Dawood Darbar, Christopher Newton-Cheh, Christian Shaffer, Peter W Macfarlane, Stefanie Heilmann-Heimbach, Peter Almgren, Paul L Huang, Nona Sotoodehnia, Elsayed Z Soliman, Andre G Uitterlinden, Albert Hofman, Oscar H Franco, Uwe Völker, Karl-Heinz Jöckel, Moritz F Sinner, Henry J Lin, Xiuqing Guo, Martin Dichgans, Erik Ingelsson, Charles Kooperberg, Olle Melander, Ruth J F Loos, Jari Laurikka, David Conen, Jonathan Rosand, Pim van der Harst, Marja-Liisa Lokki, Sekar Kathiresan, Alexandre Pereira, J Wouter Jukema, Caroline Hayward, Jerome I Rotter, Winfried März, Terho Lehtimäki, Bruno H Stricker, Mina K Chung, Stephan B Felix, Vilmundur Gudnason, Alvaro Alonso, Dan M Roden, Stefan Kääb, Daniel I Chasman, Susan R Heckbert, Emelia J Benjamin, Toshihiro Tanaka, Kathryn L Lunetta, Steven A Lubitz, Patrick T Ellinor
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
published pages: 946-952, ISSN: 1061-4036, DOI: 10.1038/ng.3843
Nature Genetics 49/6 2019-04-18
2017 Steven A. Lubitz, Xiaoyan Yin, Henry J. Lin, Matthew Kolek, J. Gustav Smith, Stella Trompet, Michiel Rienstra, Natalia S. Rost, Pedro L. Teixeira, Peter Almgren, Christopher D. Anderson, Lin Y. Chen, Gunnar Engström, Ian Ford, Karen L. Furie, Xiuqing Guo, Martin G. Larson, Kathryn L. Lunetta, Peter W. Macfarlane, Bruce M. Psaty, Elsayed Z. Soliman, Nona Sotoodehnia, David J. Stott, Kent D. Taylor, Lu-Chen Weng, Jie Yao, Bastiaan Geelhoed, Niek Verweij, Joylene E. Siland, Sekar Kathiresan, Carolina Roselli, Dan M. Roden, Pim van der Harst, Dawood Darbar, J. Wouter Jukema, Olle Melander, Jonathan Rosand, Jerome I. Rotter, Susan R. Heckbert, Patrick T. Ellinor, Alvaro Alonso, Emelia J. Benjamin
Genetic Risk Prediction of Atrial Fibrillation
published pages: 1311-1320, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.116.024143
Circulation 135/14 2019-04-18
2017 Richard Petersson, J. Gustav Smith, David A. Larsson, Öyvind Reitan, Jonas Carlson, Pyotr Platonov, Fredrik Holmqvist
Orthogonal P-wave morphology is affected by intra-atrial pressures
published pages: , ISSN: 1471-2261, DOI: 10.1186/s12872-017-0724-x
BMC Cardiovascular Disorders 17/1 2019-04-18
2017 Lu-Chen Weng, Seung Hoan Choi, Derek Klarin, J. Gustav Smith, Po-Ru Loh, Mark Chaffin, Carolina Roselli, Olivia L. Hulme, Kathryn L. Lunetta, Josée Dupuis, Emelia J. Benjamin, Christopher Newton-Cheh, Sekar Kathiresan, Patrick T. Ellinor, Steven A. Lubitz
Heritability of Atrial Fibrillation
published pages: , ISSN: 1942-3268, DOI: 10.1161/CIRCGENETICS.117.001838
Circulation: Cardiovascular Genetics 10/6 2019-04-18
2017 Francesca N. Delling, Xinjun Li, Shuo Li, Qiong Yang, Vanessa Xanthakis, Andreas Martinsson, Pontus Andell, Birgitta T. Lehman, Ewa W. Osypiuk, Plamen Stantchev, Bengt Zöller, Emelia J. Benjamin, Kristina Sundquist, Ramachandran S. Vasan, J. Gustav Smith
Heritability of Mitral Regurgitation
published pages: , ISSN: 1942-3268, DOI: 10.1161/CIRCGENETICS.117.001736
Circulation: Cardiovascular Genetics 10/5 2019-04-18
2018 Moman A. Mohammad, Sasha Koul, J. Gustav Smith, Marco Noc, Irene Lang, Michael Holzer, Peter Clemmensen, Ulf Jensen, Thomas Engstrøm, Håkan Arheden, Stefan James, Bertil Lindahl, Bernhard Metzler, David Erlinge
Predictive Value of High-Sensitivity Troponin T for Systolic Dysfunction and Infarct Size (Six Months) After ST-Elevation Myocardial Infarction
published pages: 735-743, ISSN: 0002-9149, DOI: 10.1016/j.amjcard.2018.05.005
The American Journal of Cardiology 122/5 2019-04-18
2018 Anna Helgadottir, Gudmar Thorleifsson, Solveig Gretarsdottir, Olafur A. Stefansson, Vinicius Tragante, Rosa B. Thorolfsdottir, Ingileif Jonsdottir, Thorsteinn Bjornsson, Valgerdur Steinthorsdottir, Niek Verweij, Jonas B. Nielsen, Wei Zhou, Lasse Folkersen, Andreas Martinsson, Mahyar Heydarpour, Siddharth Prakash, Gylfi Oskarsson, Tomas Gudbjartsson, Arnar Geirsson, Isleifur Olafsson, Emil L. Sigurdsson, Peter Almgren, Olle Melander, Anders Franco-Cereceda, Anders Hamsten, Lars Fritsche, Maoxuan Lin, Bo Yang, Whitney Hornsby, Dongchuan Guo, Chad M. Brummett, Gonçalo Abecasis, Michael Mathis, Dianna Milewicz, Simon C. Body, Per Eriksson, Cristen J. Willer, Kristian Hveem, Christopher Newton-Cheh, J. Gustav Smith, Ragnar Danielsen, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hilma Holm, Kari Stefansson
Genome-wide analysis yields new loci associating with aortic valve stenosis
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03252-6
Nature Communications 9/1 2019-04-18
2016 Connie Wu, Pankaj Arora, Obiajulu Agha, Liam A. Hurst, Kaitlin Allen, Daniel I. Nathan, Dongjian Hu, Pawina Jiramongkolchai, J. Gustav Smith, Olle Melander, Sander Trenson, Stefan P. Janssens, Ibrahim Domian, Thomas J. Wang, Kenneth D. Bloch, Emmanuel S. Buys, Donald B. Bloch, Christopher Newton-Cheh
Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production
published pages: 1977-1987, ISSN: 0270-7306, DOI: 10.1128/MCB.01114-15
Molecular and Cellular Biology 36/14 2019-04-18
2017 J. Gustav Smith
Molecular Epidemiology of Heart Failure
published pages: 757-769, ISSN: 2452-302X, DOI: 10.1016/j.jacbts.2017.07.010
JACC: Basic to Translational Science 2/6 2019-04-18
2018 Magnus P. Lindgren, MirNabi PirouziFard, J. Gustav Smith, Jan Sundquist, Kristina Sundquist, Bengt Zöller
A Swedish Nationwide Adoption Study of the Heritability of Heart Failure
published pages: 703, ISSN: 2380-6583, DOI: 10.1001/jamacardio.2018.1919
JAMA Cardiology 3/8 2019-04-18
2017 Mia N. Christiansen, Lars Køber, Peter Weeke, Ramachandran S. Vasan, Jørgen L. Jeppesen, J. Gustav Smith, Gunnar H. Gislason, Christian Torp-Pedersen, Charlotte Andersson
Age-Specific Trends in Incidence, Mortality, and Comorbidities of Heart Failure in Denmark, 1995 to 2012
published pages: 1214-1223, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.116.025941
Circulation 135/13 2019-04-18
2017 J. Gustav Smith, Robert E. Gerszten
Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease
published pages: 1651-1664, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.116.025446
Circulation 135/17 2019-06-19

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