Explore the words cloud of the BARCODE DIAGNOSTICS project. It provides you a very rough idea of what is the project "BARCODE DIAGNOSTICS" about.
The following table provides information about the project.
Coordinator |
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Organization address contact info |
Coordinator Country | Israel [IL] |
Project website | https://www.schroederlab.com/ |
Total cost | 1˙499˙250 € |
EC max contribution | 1˙499˙250 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-STG |
Funding Scheme | ERC-STG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-04-01 to 2021-03-31 |
Take a look of project's partnership.
# | ||||
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1 | TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY | IL (HAIFA) | coordinator | 1˙499˙250.00 |
Cancer is the leading cause of death in the Western world and the second cause of death worldwide. Despite advances in medical research, 30% of cancer patients are prescribed a medication the tumor does not respond to, or, alternatively, drugs that induce adverse side effects patients' cannot tolerate. Nanotechnologies are becoming impactful therapeutic tools, granting tissue-targeting and cellular precision that cannot be attained using systems of larger scale. In this proposal, I plan to expand far beyond the state-of-the-art and develop a conceptually new approach in which diagnostic nanoparticles are designed to retrieve drug-sensitivity information from malignant tissue inside the body. The ultimate goal of this program is to be able to predict, ahead of time, which treatment will be best for each cancer patient – an emerging field called personalized medicine. This interdisciplinary research program will expand our understandings and capabilities in nanotechnology, cancer biology and medicine. To achieve this goal, I will engineer novel nanotechnologies that autonomously maneuver, target and diagnose the various cells that compose the tumor microenvironment and its disseminated metastasis. Each nanometric system will contain a miniscule amount of a biologically-active agent, and will serve as a nano lab for testing the activity of the agents inside the tumor cells. To distinguish between system to system, and to grant single-cell sensitivity in vivo, nanoparticles will be barcoded with unique DNA fragments. We will enable nanoparticle' deep tissue penetration into primary tumors and metastatic microenvironments using enzyme-loaded particles, and study how different agents, including small-molecule drugs, proteins and RNA, interact with the malignant and stromal cells that compose the cancerous microenvironments. Finally, we will demonstrate the ability of barcoded nanoparticles to predict adverse, life-threatening, side effects, in a personalized manner.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Omer Adir, Maria Poley, Gal Chen, Sahar Froim, Nitzan Krinsky, Jeny Shklover, Janna Shainskyâ€Roitman, Twan Lammers, Avi Schroeder Integrating Artificial Intelligence and Nanotechnology for Precision Cancer Medicine published pages: 1901989, ISSN: 0935-9648, DOI: 10.1002/adma.201901989 |
Advanced Materials | 2019-08-29 |
2019 |
Hanan Abumanhal-Masarweh, Dana da Silva, Maria Poley, Assaf Zinger, Evgenya Goldman, Nitzan Krinsky, Ron Kleiner, Gal Shenbach, Josh E. Schroeder, Jeny Shklover, Janna Shainsky-Roitman, Avi Schroeder Tailoring the lipid composition of nanoparticles modulates their cellular uptake and affects the viability of triple negative breast cancer cells published pages: 331-341, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.06.025 |
Journal of Controlled Release 307 | 2019-08-29 |
2018 |
Dana da Silva, Maya Kaduri, Maria Poley, Omer Adir, Nitzan Krinsky, Janna Shainsky-Roitman, Avi Schroeder Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems published pages: 9-14, ISSN: 1385-8947, DOI: 10.1016/j.cej.2018.01.010 |
Chemical Engineering Journal 340 | 2019-04-18 |
2016 |
Nitzan Krinsky, Maya Kaduri, Janna Shainsky-Roitman, Mor Goldfeder, Eran Ivanir, Itai Benhar, Yuval Shoham, Avi Schroeder A Simple and Rapid Method for Preparing a Cell-Free Bacterial Lysate for Protein Synthesis published pages: e0165137, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0165137 |
PLOS ONE 11/10 | 2019-06-19 |
2016 |
Zvi Yaari, Dana da Silva, Assaf Zinger, Evgeniya Goldman, Ashima Kajal, Rafi Tshuva, Efrat Barak, Nitsan Dahan, Dov Hershkovitz, Mor Goldfeder, Janna Shainsky Roitman, Avi Schroeder Theranostic barcoded nanoparticles for personalized cancer medicine published pages: 13325, ISSN: 2041-1723, DOI: 10.1038/ncomms13325 |
Nature Communications 7 | 2019-06-19 |
2017 |
Evgeniya Goldman, Assaf Zinger, Dana da Silva, Zvi Yaari, Ashima Kajal, Dikla Vardi-Oknin, Mor Goldfeder, Josh E. Schroeder, Janna Shainsky-Roitman, Dov Hershkovitz, Avi Schroeder Nanoparticles target early-stage breast cancer metastasis in vivo published pages: 43LT01, ISSN: 0957-4484, DOI: 10.1088/1361-6528/aa8a3d |
Nanotechnology 28/43 | 2019-06-19 |
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The information about "BARCODE DIAGNOSTICS" are provided by the European Opendata Portal: CORDIS opendata.
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