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SmartNanoTox SIGNED

Smart Tools for Gauging Nano Hazards

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SmartNanoTox project word cloud

Explore the words cloud of the SmartNanoTox project. It provides you a very rough idea of what is the project "SmartNanoTox" about.

complete toxicity routs self careful prediction points intelligent events biology characterisation post successful nm statistical molecular vivo discrimination respiratory clear costly made mechanistic list blanket nanomaterial toxicological materials animal straightforward relate mechanism bionano consequent exposure silico nanotoxicity nanomaterials material consistent vitro identification modern representative qsars economic nanoparticle definitive tests grouping human experiments on dangers reduce computational exhaustive progress interactions interface formulate

Project "SmartNanoTox" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	http://www.smartnanotox.eu
Total cost	8˙147˙304 €
EC max contribution	7˙996˙124 € (98%)
Programme	1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies)
Code Call	H2020-NMP-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2020-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	coordinator	1˙695˙517.00
2	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Organization address address: INGOLSTADTER LANDSTRASSE 1 city: NEUHERBERG postcode: 85764 website: www.helmholtz-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NEUHERBERG)	participant	1˙058˙870.00
3	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	857˙548.00
4	INSTITUT JOZEF STEFAN INSTITUT JOZEF STEFAN Organization address address: Jamova 39 city: LJUBLJANA postcode: 1000 website: www.ijs.si contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SI (LJUBLJANA)	participant	825˙250.00
5	DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO Organization address address: LERSO PARKALLE 105 city: KOBENHAVN postcode: 2100 website: www.nrcwe.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	799˙820.00
6	INSTITUT NATIONAL DE RECHERCHE ET DE SECURITE POUR LA PREVENTION DES ACCIDENTS DU TRAVAIL ET DES MALADIES PROFESSIONNELLES ASSOCIATION INSTITUT NATIONAL DE RECHERCHE ET DE SECURITE POUR LA PREVENTION DES ACCIDENTS DU TRAVAIL ET DES MALADIES PROFESSIONNELLES ASSOCIATION Organization address address: BOULEVARD RICHARD LENOIR 65 city: PARIS postcode: 75011 website: www.inrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	799˙327.00
7	UNIVERSITE DE LORRAINE UNIVERSITE DE LORRAINE Organization address address: COURS LEOPOLD 34 city: NANCY CEDEX postcode: 54052 website: www.univ-lorraine.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (NANCY CEDEX)	participant	710˙793.00
8	STOCKHOLMS UNIVERSITET STOCKHOLMS UNIVERSITET Organization address address: UNIVERSITETSVAGEN 10 city: STOCKHOLM postcode: 10691 website: www.su.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	666˙625.00
9	VITROCELL SYSTEMS GMBH VITROCELL SYSTEMS GMBH Organization address address: FABRIK SONNTAG 3 city: WALDKIRCH postcode: 79183 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WALDKIRCH)	participant	320˙348.00
10	TYOTERVEYSLAITOS TYOTERVEYSLAITOS Organization address address: TOPELIUKSENKATU 41 B city: HELSINKI postcode: 250 website: www.ttl.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	203˙273.00
11	DASSAULT SYSTEMES BIOVIA LIMITED DASSAULT SYSTEMES BIOVIA LIMITED Organization address address: MILTON ROAD CAMBRIDGE SCIENCE PARK UNIT 334 city: CAMBRIDGE postcode: CB4 0WN website: www.accelrys.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	58˙750.00
12	STATENS ARBEIDSMILJOINSTITUTT STATENS ARBEIDSMILJOINSTITUTT Organization address address: GYDAS VEI 8 city: OSLO postcode: 363 website: www.stami.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	0.00

Map

Project objective

A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on one hand on systems biology, on another hand on statistical and other computational methods of analysis. In this project, using a comprehensive self-consistent study, which includes in-vivo, in-vitro and in-silico research, we address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling. This approach will allow us to formulate novel set of toxicological mechanism-aware end-points that can be assessed in by means of economic and straightforward tests. Using the exhaustive list of end-points and pathways for the selected nanomaterials and exposure routs, we will enable clear discrimination between different pathways and relate the toxicity pathway to the properties of the material via intelligent QSARs. If successful, this approach will allow grouping of materials based on their ability to produce the pathway-relevant key events, identification of properties of concern for new materials, and will help to reduce the need for blanket toxicity testing and animal testing in the future.

Deliverables

List of deliverables.
Position paper on predictive in vitro models	Documents, reports	2020-02-25 11:41:07
Establishment of a stakeholder advisory board	Websites, patent fillings, videos etc.	2020-02-25 11:41:06
List of NMs	Documents, reports	2020-02-25 11:41:06
Research data management plan	Open Research Data Pilot	2020-02-25 11:41:07
Labelled NPs for tracking within cells and tissues	Documents, reports	2020-02-25 11:41:06
List of nanomaterials and respective doses to be tested as TP benchmark	Documents, reports	2020-02-25 11:41:06
Development of the data portal	Websites, patent fillings, videos etc.	2020-02-25 11:41:06
PMFs and binding free energies for interaction of NM with building blocks of biomolecules	Documents, reports	2020-02-25 11:41:06
Isolation and archiving of biological samples for subsequent analysis	Documents, reports	2020-02-25 11:41:06
In vivo samples for transcriptomics studies (instillation)	Documents, reports	2020-02-25 11:41:06
Identify and score the pathological outcome of the in vivo exposures	Documents, reports	2020-02-25 11:41:06
Report of end-localization of NPs within relevant cells	Documents, reports	2020-02-25 11:41:06

Take a look to the deliverables list in detail: detailed list of SmartNanoTox deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Hana Majaron, BoÅ¡tjan Kokot, Aleksandar SebastijanoviÄ‡, Carola Voss, Rok Podlipec, Patrycja Zawilska, Trine Berthing, Carolina Ballester LÃ³pez, Pernille HÃ¸gh Danielsen, Claudia Contini, Mikhail Ivanov, Ana KriÅ¡elj, Petra ÄŒotar, Qiaoxia Zhou, Jessica Ponti, Vadim Zhernovkov, Matthew Schneemilch, Zahra Manel Doumandji, Mojca PuÅ¡nik, Polona Umek, Stane Pajk, Olivier Joubert, Otmar Schmid, Izto From the roundabout of molecular events to nanomaterial-induced chronic inflammation prediction published pages: , ISSN: 1943-0264, DOI: 10.1101/2020.02.27.966036	BioRxiv	2020-04-24
2020	Martin Thomas Horsch, Christoph Niethammer, Gianluca Boccardo, Paola Carbone, Silvia Chiacchiera, Mara Chiricotto, Joshua D. Elliott, Vladimir Lobaskin, Philipp Neumann, Peter Schiffels, Michael A. Seaton, Ilian T. Todorov, Jadran Vrabec, Welchy Leite Cavalcanti Semantic Interoperability and Characterization of Data Provenance in Computational Molecular Engineering published pages: 1313-1329, ISSN: 0021-9568, DOI: 10.1021/acs.jced.9b00739	Journal of Chemical & Engineering Data 65/3	2020-04-24
2020	Niels Hadrup, Vadim Zhernovkov, Nicklas Raun Jacobsen, Carola Voss, Maximilian Strunz, Meshal Ansari, Herbert B. Schiller, Sabina Halappanavar, Sarah S. Poulsen, Boris Kholodenko, Tobias Stoeger, Anne Thoustrup Saber, Ulla Vogel Acute Phase Response as a Biological Mechanism-of-Action of (Nano)particle-Induced Cardiovascular Disease published pages: 1907476, ISSN: 1613-6810, DOI: 10.1002/smll.201907476	Small	2020-04-24
2020	Fernando LuÃs Barroso da Silva, Paolo Carloni, David Cheung, Grazia Cottone, Serena Donnini, E. Allen Foegeding, Muhammad Gulzar, Jean Christophe Jacquier, Vladimir Lobaskin, Donal MacKernan, Zeynab Mohammad Hosseini Naveh, Ravi Radhakrishnan, Erik E. Santiso Understanding and Controlling Food Protein Structure and Function in Foods: Perspectives from Experiments and Computer Simulations published pages: 365-387, ISSN: 1941-1413, DOI: 10.1146/annurev-food-032519-051640	Annual Review of Food Science and Technology 11/1	2020-04-24
2019	Doumandji Zahra, Safar Ramia, Lovera-Leroux MÃ©lanie, Nahle Sara, Cassidy Hilary, Matallanas David, Rihn Bertrand, Ferrari Luc, Joubert Olivier Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles published pages: , ISSN: 0742-2091, DOI: 10.1007/s10565-019-09484-6	Cell Biology and Toxicology	2020-02-25
2019	Pernille HÃ¸gh Danielsen, Kristina Bram Knudsen, Janez Å trancar, Polona Umek, Tilen KokliÄ, Maja Garvas, Esa Vanhala, Sauli Savukoski, Yaobo Ding, Anne Mette Madsen, Nicklas Raun Jacobsen, Ingrid Konow Weydahl, Trine Berthing, Sarah SÃ¸s Poulsen, Otmar Schmid, Henrik Wolff, Ulla Vogel Effects of physicochemical properties of TiO2 nanomaterials for pulmonary inflammation, acute phase response and alveolar proteinosis in intratracheally exposed mice published pages: 114830, ISSN: 0041-008X, DOI: 10.1016/j.taap.2019.114830	Toxicology and Applied Pharmacology	2020-02-25
2019	M. Schneemilch, N. Quirke Free energy of adhesion of lipid bilayers on titania surfaces published pages: 134707, ISSN: 0021-9606, DOI: 10.1063/1.5120810	The Journal of Chemical Physics 151/13	2020-02-25
2019	David Power, Ian Rouse, Stefano Poggio, Erik Brandt, Hender Lopez, Alexander Lyubartsev, Vladimir Lobaskin A multiscale model of protein adsorption on a nanoparticle surface published pages: 84003, ISSN: 0965-0393, DOI: 10.1088/1361-651x/ab3b6e	Modelling and Simulation in Materials Science and Engineering 27/8	2020-02-25
2019	Vadim Zhernovkov, Tapesh Santra, Hilary Cassidy, Oleksii Rukhlenko, David Matallanas, Aleksandar Krstic, Walter Kolch, Vladimir Lobaskin, Boris N Kholodenko An integrative computational approach for a prioritization of key transcription regulators associated with nanomaterial-induced toxicity published pages: , ISSN: 1096-6080, DOI: 10.1093/toxsci/kfz151	Toxicological Sciences	2020-02-25
2019	M. Schneemilch, N. Quirke Erratum: â€œFree energy of adhesion of lipid bilayers on silica surfacesâ€ [J. Chem. Phys. 148, 194704 (2018)] published pages: 229901, ISSN: 0021-9606, DOI: 10.1063/1.5111197	The Journal of Chemical Physics 150/22	2020-02-25
2019	Laurent GatÃ©, Kristina Bram Knudsen, Carole Seidel, Trine Berthing, LaÃ«titia ChÃ©zeau, Nicklas Raun Jacobsen, Sarah Valentino, HÃ¥kan Wallin, SÃ©bastien Bau, Henrik Wolff, Sylvie SÃ©billaud, MylÃ¨ne Lorcin, StÃ©phane Grossmann, StÃ©phane Viton, HervÃ© Nunge, Christian Darne, Ulla Vogel, FrÃ©dÃ©ric Cosnier Pulmonary toxicity of two different multi-walled carbon nanotubes in rat: Comparison between intratracheal instillation and inhalation exposure published pages: 17-31, ISSN: 0041-008X, DOI: 10.1016/j.taap.2019.05.001	Toxicology and Applied Pharmacology 375	2020-02-25

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