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MAIT SIGNED

Evolutionary conserved T cells specific for a microbial metabolite: deciphering their development in the thymus and mapping their interactions with the gut microbiota in vivo.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MAIT project word cloud

Explore the words cloud of the MAIT project. It provides you a very rough idea of what is the project "MAIT" about.

polyclonal    dysbiosis    conservation    metabolite    thymus    mucosal    technologies    mr1    remained    anti    scarcity    presented    frequency    ligands    obesity    subset    mhc    mechanisms    15    mouse    model    molecule    expand    bounds    strain    modified    microbiota    flora    50    building    tools    play    adaptive    pathologies    acquired    differentiation    overcome    interactions    indicating    abundant    guarantee    commensal    re    permanently    biological    host    me    lineage    express    conserved    immune    memory    implicated    transcriptomic    tcr    free    phenotype    vivo    elucidate    diabetes    expertise    transfer    bacteria    class    transgenic    germ    microbial    map    inter    blood    mucosa    first    liver    ago    admittedly    integrate    ib    ms    ibd    species    microbes    acquire    insights    colonization    models    maits    commensals    creation    cells    mice    antigens    invariant    leads    limited    recognizing    infers    periphery    expansion    lab    specificity    competitiveness    human    laboratory    gut    semi    evolutionary    peripheral   

Project "MAIT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://science.institut-curie.org/research/integrated-biology/u932-immunity-and-cancer/team-lantz/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Mucosal Associated Invariant T cells (MAITs) represent an evolutionary conserved subset that express a semi-invariant TCR recognizing a new class of microbial metabolite antigens presented by the MHC class Ib molecule, MR1. In addition to their wide anti-microbial specificity, the high inter-species conservation of both MR1 and invariant TCR infers an important biological role for MAITs. MAITs are abundant in human blood (1-8 % of T cells), mucosa and liver (20-50%). After development in the thymus, MAITs reach the periphery where they acquire a memory phenotype and expand in a process that requires a commensal flora, indicating that MAITs play a role in host-commensals interactions. Admittedly MAITs blood frequency is modified in several pathologies in which dysbiosis of the gut microbiota has been implicated such as IBD, MS, type 2 diabetes and obesity. MAITs were first described over 15 years ago by the Host lab, but the understanding of their development has remained limited because of their scarcity in laboratory mice. Here we will overcome this challenge by using a new mouse strain with increased frequency of polyclonal MAITs. Using my expertise acquired in the US and building on unique tools, we will: 1) Define MAITs lineage: we will use a transcriptomic approach together with dedicated transgenic mouse models to determine how MAITs selection leads to their specific differentiation program in the thymus. 2) Elucidate the mechanisms of MAITs peripheral expansion: we will use germ-free mice and modified bacteria to map the in vivo availability of MAITs ligands upon colonization with commensal microbes. The proposal will provide insights into an evolutionary conserved model of interactions between the adaptive immune system and the gut microbiota. By enabling me to permanently re-integrate the EU, this project will also guarantee transfer of technologies and creation of new bounds between the US and the EU, and will increase the EU competitiveness.

 Publications

year authors and title journal last update
List of publications.
2017 Olivier Lantz, François Legoux
MAIT cells: an historical and evolutionary perspective
published pages: , ISSN: 0818-9641, DOI: 10.1111/imcb.1034
Immunology and Cell Biology 2019-06-13

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