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GolgiBiosSys SIGNED

Identification and characterisation of plant Golgi biosynthetic multiprotein systems

Total Cost €

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EC-Contrib. €

0

Partnership

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 GolgiBiosSys project word cloud

Explore the words cloud of the GolgiBiosSys project. It provides you a very rough idea of what is the project "GolgiBiosSys" about.

skills    amount    proteins    independent    throughput    firstly    organic    earth    little    auxiliary    lipid    cooperative    conjunction    interactions    composition    organisation    knockout    action    presented    humanity    molecular    thirdly    data    biosynthetic    proteomic    academic    lines    sub    deepen    bioenergy    separation    glycosylation    performed    immunoprecipitation    apparatus    structures    quantitative    pivotal    organelle    insights    cell    complexes    food    experimental    membrane    industries    fibre    carbohydrate    protein    performs    technique    biomaterial    yield    localisation    map    carbon    model    precise    accomplishment    polysaccharides    least    validated    proteome    assignment    gain    fuel    myself    docking    expertise    renewable    researcher    secondly    abundant    stoichiometries    leadership    governed    recalcitrant    biochemical    interaction    measured    functions    biosynthesis    multiprotein    material    enzymes    golgi    arrangement    orchestrated    thought    biosphere    secretion    relevance    functional    organisational   

Project "GolgiBiosSys" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 187˙419.00

Map

 Project objective

The Golgi apparatus is a system of organised membrane structures that performs pivotal cell functions: biosynthesis and secretion of polysaccharides, protein and lipid glycosylation. The relevance of this organelle is measured by the amount of biomaterial produced by its activity. The highly abundant polysaccharides account for at least a third of all renewable organic carbon on Earth and are of great importance to the biosphere and to humanity, providing food, fibre and fuel. The functionality of the Golgi is thought to be governed by molecular organisational features, as the precise arrangement of its membrane proteins. Each of the numerous biosynthetic pathways performed in the Golgi requires the cooperative and orchestrated action and interaction of several different enzymes and auxiliary proteins. Currently very little is known about the composition and sub-Golgi localisation of such multiprotein systems. Firstly, a comprehensive insight into the interaction map of the Golgi proteome is needed. I propose to develop and apply a technique that will allow high-throughput assignment of membrane protein interactions, and identify stoichiometries. An experimental design is presented based on separation of membrane protein complexes in conjunction with state of the art quantitative proteomic approaches. Secondly, the results will be validated on selected multiprotein systems by immunoprecipitation and functional biochemical studies on knockout lines. Thirdly, the data will be used to model the interactions by protein-protein docking. The accomplishment of this project will provide new insights into the organisation and activity of the biosynthetic systems. Such insight is of great value to the production of specific polysaccharides, tailored to yield less recalcitrant material for the bioenergy and carbohydrate industries. Through this work I aim to deepen my academic expertise, gain technical and leadership skills and to establish myself as an independent researcher.

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The information about "GOLGIBIOSSYS" are provided by the European Opendata Portal: CORDIS opendata.

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