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SpheriCal

Reference Certification and Commercialisation of “Universal” Mass Spectrometry Calibration Standards

Total Cost €

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EC-Contrib. €

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Partnership

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 SpheriCal project word cloud

Explore the words cloud of the SpheriCal project. It provides you a very rough idea of what is the project "SpheriCal" about.

material    biomedical    nature    miss    discovery    recorded    fingerprint    medicine    positives    insufficient    validation    resolution    cover    peak    data    clinically    experiments    lucrative    time    cutting    environmental    commercialize    organic    esi    reinforce    calibrants    species    industries    maldi    instrumentation    synthetic    components    biochemistry    spherical    reg    infection    preparation    techniques    additional    regular    monitoring    lack    techno    runs    edge    bacterial    bacteria    reference    analytical    attempting    drug    molecules    false    limiting    building    regulatory    absolute    throughput    technique    economic    spectrometers    strict    markets    certified    consuming    clinical    drift    overcome    ionization    diagnostics    pf    feasibility    status    standards    polymers    ms    biological    efficiency    6month    im    calibration    accurately    crm    spectrometry    electrospray    misleading    confirm    trials    disadvantages    accurate    microbiology    critically    mass    successful    analytes    continuous    shortcomings    poor    assignment    raw    biomolecules    preliminary    prominence    exhibits    media    benchmark    small   

Project "SpheriCal" data sheet

The following table provides information about the project.

Coordinator
POLYMER FACTORY SWEDEN AB 

Organization address
address: TEKNIKRINGEN 48 1 TR
city: STOCKHOLM
postcode: 114 28
website: www.polymerfactory.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://www.polymerfactory.com/horizon-2020
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-1
 Funding Scheme SME-1
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLYMER FACTORY SWEDEN AB SE (STOCKHOLM) coordinator 50˙000.00

Map

 Project objective

Mass spectrometry (MS) is an established benchmark analytical technique to analyse biomolecules, organic molecules and synthetic polymers. MS techniques such as MALDI, IM-MS and ESI (electrospray ionization) are widely used in a range of fields such as biochemistry, clinical microbiology, medicine and drug discovery. Its prominence in these fields is due to the ability to accurately measure the absolute mass, and therefore species present, in complex analytes such as raw biological media, in high throughput experiments. For example, MALDI is used clinically to identify the nature of bacterial infection through the unique biological fingerprint of each bacteria type.

Critically, due to small and continuous changes in the various system components, data recorded exhibits a significant drift over time and between analysis runs, leading to peak miss-assignment and misleading data such as false positives. Therefore, mass spectrometers require regular calibration with a set of known standards in order to provide accurate and meaningful data. Without accurate calibration, MS instrumentation will not produce reliable data, limiting the advancement and efficiency of biomedical and clinical industries and environmental monitoring organizations. Existing calibrants have disadvantages such as time-consuming preparation, poor resolution, cover an insufficient mass range and lack Certified Reference Material (CRM) status.

To overcome these shortcomings of the existing calibrants, PF aim to commercialize a set of cutting-edge synthetic calibration standards called SpheriCal®. We are now attempting to reinforce SpheriCal® as a calibration system with CRM status – allowing access to additional lucrative markets such as clinical diagnostics and other markets with strict regulatory requirements.

Building upon successful development and validation through preliminary end-user trials, through this 6month Phase 1 project we aim to confirm the techno-economic feasibility of SpheriCal

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The information about "SPHERICAL" are provided by the European Opendata Portal: CORDIS opendata.

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