NanoPokers SIGNED
Deciphering cell heterogeneity in tumors using arrays of nanowires to controllably poke single cells in longitudinal studies
Total Cost €
0EC-Contrib. €
0Partnership
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Project "NanoPokers" data sheet
The following table provides information about the project.
| Coordinator |
LUNDS UNIVERSITET
Organization address contact info |
| Coordinator Country | Sweden [SE] |
| Project website | https://portal.research.lu.se/portal/en/persons/christelle-prinz |
| Total cost | 2˙621˙251 € |
| EC max contribution | 2˙621˙251 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-09-01 to 2022-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | LUNDS UNIVERSITET | SE (LUND) | coordinator | 2˙621˙251.00 |
Map
Project objective
Cancer is responsible for 20% of all deaths in Europe. Current cancer research is based on cell ensemble measurements or on snapshot studies of individual cells. However, cancer is a systemic disease, involving many cells that interact and evolve over time in a complex manner, which cell ensemble studies and snapshot studies cannot grasp. It is therefore crucial to investigate cancer at the single cell level and in longitudinal studies (over time). Despite the recent developments in micro- and nanotechnologies, combined with live cell imaging, today, there is no method available that meets the crucial need for global monitoring of individual cell responses to stimuli/perturbation in real-time. This project addresses this crucial need by combining super resolution live-cell imaging and the development of sensors, as well as injection devices based on vertical nanowire arrays. The devices will penetrate multiple single cells in a fully controlled manner, with minimal invasiveness.
The objectives of the project are: 1) To develop nanowire based-tools in order to gain controlled and reliable access to the cell interior with minimal invasiveness. 2) Developing mRNA sensing and biomolecule injection capabilities based on nanowires. 3) Performing longitudinal single cell studies in tumours, including monitoring gene expression in real time, under controlled cell perturbation.
By enabling global, long term monitoring of individual tumour cells submitted to controlled stimuli, the project will open up new horizons in Biology and in Medical Research. It will enable ground-breaking discoveries in understanding the complexity of molecular events underlying the disease. This cross-disciplinary project will lead to paradigm-shifting research, which will enable the development of optimal treatment strategies. This will be applicable, not only for cancer, but also for a broad range of diseases, such as diabetes and neurodegenerative diseases.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Mercy Lard, Heiner Linke, Christelle N Prinz Biosensing using arrays of vertical semiconductor nanowires: mechanosensing and biomarker detection published pages: 214003, ISSN: 0957-4484, DOI: 10.1088/1361-6528/ab0326 |
Nanotechnology 30/21 | 2020-03-25 |
| 2018 |
Zhen Li, Sofia Kamlund, Till Ryser, Mercy Lard, Stina Oredsson, Christelle N. Prinz Single cell analysis of proliferation and movement of cancer and normal-like cells on nanowire array substrates published pages: 7042-7049, ISSN: 2050-7518, DOI: 10.1039/c8tb02049c |
Journal of Materials Chemistry B 6/43 | 2020-03-25 |
| 2018 |
Damiano Verardo, Frida W. Lindberg, Nicklas Anttu, Cassandra S. Niman, Mercy Lard, Aleksandra P. Dabkowska, Tommy Nylander, Alf MÃ¥nsson, Christelle N. Prinz, Heiner Linke Nanowires for Biosensing: Lightguiding of Fluorescence as a Function of Diameter and Wavelength published pages: 4796-4802, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b01360 |
Nano Letters 18/8 | 2020-03-25 |
| 2017 |
Joanna Oracz, Karl Adolfsson, Volker Westphal, Czesław Radzewicz, Magnus T. Borgström, Steffen J. Sahl, Christelle N. Prinz, Stefan W. Hell Ground State Depletion Nanoscopy Resolves Semiconductor Nanowire Barcode Segments at Room Temperature published pages: 2652-2659, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b00468 |
Nano Letters 17/4 | 2020-03-25 |
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