Explore the words cloud of the GCB-PRID project. It provides you a very rough idea of what is the project "GCB-PRID" about.
The following table provides information about the project.
Coordinator |
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Organization address contact info |
Coordinator Country | Germany [DE] |
Project website | https://www.translatum.tum.de/research-groups/immunopathology-and-signal-transduction/ |
Total cost | 1˙998˙066 € |
EC max contribution | 1˙998˙066 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-CoG |
Funding Scheme | ERC-COG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-09-01 to 2022-08-31 |
Take a look of project's partnership.
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1 | KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN | DE (MUENCHEN) | coordinator | 1˙998˙066.00 |
Antibodies secreted by B cells of the adaptive immune system establish an essential barrier against bacteria and viruses and their presence is the hallmark of protective vaccinations. B cells are licensed for their tasks during germinal center (GC) reactions and differentiation into antibody-secreting plasma cells. Unfortunately, B cell-derived autoantibodies and proinflammatory cytokines can cause or contribute to autoimmune diseases.
While major transcription factor networks regulating protective (or pathogenic) GCB cell responses have been identified and characterized, little is known about the post-transcriptional regulation by RNA-binding proteins (RBP), whose number rivals that of transcription factors. We postulate that RBPs exercise critical post-transcriptional control over germinal center B (GCB) and plasmacytic cell physiology and we aim to identify and molecularly characterize these regulatory mechanisms.
To this end, we will complement sophisticated genetic mouse models with novel cell culture systems. We will monitor RBP activity with fluorescent sensors and use proteomics to reveal RBPs regulating the protein abundance of critical mediators of GCB and plasmacytic cell fates. In addition, we will conduct genetic screens to uncover relevant functions of a short list of 40 RBPs, whose protein expression we found to differ significantly between GCB and mantle zone B cells. Ultimately, we will use cellular immunology and RNA biochemistry to elucidate how these RBPs exert their post-transcriptional control.
Through the integrated power of our multi-disciplinary approach we will thus pinpoint and investigate the functions of key RBPs regulating the biology of GCB and plasmacytic cells. GCB-PRID promises to uncover profoundly new insights into post-transcriptional regulation of adaptive immunity. Thereby, this groundbreaking research aims to reveal novel molecular targets for the treatment of autoimmune diseases, whose incidence is steadily on the rise.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Maike Kober-Hasslacher, Marc Schmidt-Supprian The Unsolved Puzzle of c-Rel in B Cell Lymphoma published pages: 941, ISSN: 2072-6694, DOI: 10.3390/cancers11070941 |
Cancers 11/7 | 2020-01-20 |
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The information about "GCB-PRID" are provided by the European Opendata Portal: CORDIS opendata.
High-throughput single-cell phenotypic analysis of functional antibody repertoires
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