Opendata, web and dolomites

GCB-PRID SIGNED

Post-transcriptional Regulation of Germinal Center B Cell Responses in Immunity and Disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 GCB-PRID project word cloud

Explore the words cloud of the GCB-PRID project. It provides you a very rough idea of what is the project "GCB-PRID" about.

post    sophisticated    rbp    networks    exert    thereby    abundance    little    cellular    proteomics    power    antibody    autoimmune    bacteria    pathogenic    promises    significantly    culture    functions    plasma    fluorescent    insights    genetic    mouse    elucidate    binding    cells    conduct    pinpoint    groundbreaking    found    immunity    prid    postulate    critical    proteins    screens    proinflammatory    biology    molecularly    mantle    germinal    mediators    transcriptional    list    licensed    exercise    complement    profoundly    secreting    hallmark    gc    cytokines    gcb    autoantibodies    models    ultimately    reactions    sensors    monitor    plasmacytic    expression    regulation    immune    immunology    molecular    differentiation    mechanisms    regulatory    biochemistry    unfortunately    incidence    regulating    fates    transcription    rbps    steadily    differ    cell    barrier    protein    rivals    secreted    viruses    uncover    protective    adaptive    antibodies    reveal    disciplinary    vaccinations    physiology    diseases    zone    center    rna    treatment   

Project "GCB-PRID" data sheet

The following table provides information about the project.

Coordinator
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN 

Organization address
address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675
website: http://www.med.tu.muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.translatum.tum.de/research-groups/immunopathology-and-signal-transduction/
 Total cost 1˙998˙066 €
 EC max contribution 1˙998˙066 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN DE (MUENCHEN) coordinator 1˙998˙066.00

Map

 Project objective

Antibodies secreted by B cells of the adaptive immune system establish an essential barrier against bacteria and viruses and their presence is the hallmark of protective vaccinations. B cells are licensed for their tasks during germinal center (GC) reactions and differentiation into antibody-secreting plasma cells. Unfortunately, B cell-derived autoantibodies and proinflammatory cytokines can cause or contribute to autoimmune diseases.

While major transcription factor networks regulating protective (or pathogenic) GCB cell responses have been identified and characterized, little is known about the post-transcriptional regulation by RNA-binding proteins (RBP), whose number rivals that of transcription factors. We postulate that RBPs exercise critical post-transcriptional control over germinal center B (GCB) and plasmacytic cell physiology and we aim to identify and molecularly characterize these regulatory mechanisms.

To this end, we will complement sophisticated genetic mouse models with novel cell culture systems. We will monitor RBP activity with fluorescent sensors and use proteomics to reveal RBPs regulating the protein abundance of critical mediators of GCB and plasmacytic cell fates. In addition, we will conduct genetic screens to uncover relevant functions of a short list of 40 RBPs, whose protein expression we found to differ significantly between GCB and mantle zone B cells. Ultimately, we will use cellular immunology and RNA biochemistry to elucidate how these RBPs exert their post-transcriptional control.

Through the integrated power of our multi-disciplinary approach we will thus pinpoint and investigate the functions of key RBPs regulating the biology of GCB and plasmacytic cells. GCB-PRID promises to uncover profoundly new insights into post-transcriptional regulation of adaptive immunity. Thereby, this groundbreaking research aims to reveal novel molecular targets for the treatment of autoimmune diseases, whose incidence is steadily on the rise.

 Publications

year authors and title journal last update
List of publications.
2019 Maike Kober-Hasslacher, Marc Schmidt-Supprian
The Unsolved Puzzle of c-Rel in B Cell Lymphoma
published pages: 941, ISSN: 2072-6694, DOI: 10.3390/cancers11070941
Cancers 11/7 2020-01-20

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GCB-PRID" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GCB-PRID" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

RECON (2019)

Reprogramming Conformation by Fluorination: Exploring New Areas of Chemical Space

Read More  

MOBETA (2020)

Motor cortical beta bursts for movement planning and evaluation: Mechanisms, functional roles, and development

Read More  

Back2theFuture (2020)

Back to the Future: Future expectations and actions in late medieval and early modern Europe, c.1400-c.1830

Read More