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ANTIVIRALS SIGNED

European Training Network on Antiviral Drug Development

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ANTIVIRALS project word cloud

Explore the words cloud of the ANTIVIRALS project. It provides you a very rough idea of what is the project "ANTIVIRALS" about.

six sme companies specialised partnership disciplines smes skills education few losses possibilities herpesviruses antivirals academic perspectives supplemented viral entire spectrum leaders career limited introduce drugs courses oriented multidisciplinary clear treat industrial consists prepares unmet universities intersectoral individual therapy institutes offers economic trained complementary specialized hiv academia talented incl antiviral industry mortality research licensed experts disease pathogens 15 workshops secondments worldwide organize covers discovery training instrument conference human virus infections influenza bridging hcv gap viruses actively outstanding network esrs drug local fill broad

Project "ANTIVIRALS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.antivirals-etn.eu
Total cost	3˙837˙214 €
EC max contribution	3˙837˙214 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-03-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	510˙748.00
2	CARDIFF UNIVERSITY CARDIFF UNIVERSITY Organization address address: NEWPORT ROAD 30-36 city: CARDIFF postcode: CF24 ODE website: www.cardiff.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CARDIFF)	participant	546˙575.00
3	UNIVERSITE D'AIX MARSEILLE UNIVERSITE D'AIX MARSEILLE Organization address address: Boulevard Charles Livon 58 city: Marseille postcode: 13284 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Marseille)	participant	525˙751.00
4	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	510˙748.00
5	UNIVERSITATSKLINIKUM HEIDELBERG UNIVERSITATSKLINIKUM HEIDELBERG Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 website: www.klinikum.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	498˙432.00
6	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	402˙055.00
7	VIROVET VIROVET Organization address address: AMBACHTENLAAN 1 city: LEUVEN postcode: 3001 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	250˙560.00
8	AICURIS GMBH & CO. KG AICURIS GMBH & CO. KG Organization address address: FRIEDRICH EBERT STR 475 city: WUPPERTAL postcode: 42117 website: www.aicuris.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WUPPERTAL)	participant	249˙216.00
9	UNIVERSITAT WIEN UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	244˙061.00
10	COMPLIX LUXEMBOURG SA COMPLIX LUXEMBOURG SA Organization address address: 84 VAL FLEURI city: LUXEMBOURG postcode: 1526 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (LUXEMBOURG)	participant	99˙063.00
11	ARATANA THERAPEUTICS NV ARATANA THERAPEUTICS NV Organization address address: AMBACHTENLAAN 1 city: HEVERLEE postcode: 3001 website: www.okapi-sciences.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (HEVERLEE)	participant	0.00
12	COMPLIX NV COMPLIX NV Organization address address: AGORALAAN BUILDING A BIS BIOVILLE city: DIEPENBEEK postcode: 3590 website: www.complix.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (DIEPENBEEK)	participant	0.00
13	Virology Education Virology Education Organization address address: Biltstraat 106 city: Utrecht postcode: 3572 BJ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Utrecht)	partner	0.00

Map

Project objective

Viral infections are a major cause of disease, mortality and economic losses worldwide. Antiviral therapy is an essential instrument to control virus infections. At present, however, licensed antiviral drugs have been developed only against a limited number of viruses (e.g. HIV, HCV, influenza, herpesviruses). There is a clear and unmet need for antiviral drugs to treat infections with other important human pathogens.

Europe needs well-trained experts with multidisciplinary skills to advance the antiviral drug development field. However, few, if any, European universities or research institutes have the ability to deliver an intersectoral training programme that covers the broad spectrum of disciplines important for antiviral drug development.

The ANTIVIRALS partnership has been established to fill this gap. It consists of six outstanding European academic partners and four industrial partners (two large R&D companies, of which one is specialized in antiviral drug discovery and development, and two SMEs), and two partner organisations (incl. one SME specialised in education). All partners are leaders in their field, ensuring state-of-the-art training possibilities, and their skills are highly complementary.

ANTIVIRALS aims to introduce 15 ESRs to state-of-the-art knowledge and technology applied in antiviral drug development through both local and network-wide training activities. Individual research projects, research training workshops and intersectoral secondments will be supplemented with complementary skills courses and dissemination activities to improve career development and perspectives. The industrial partners are actively involved in the entire programme and will organize an industry-oriented conference aimed at further bridging the gap between academia and industry.

Thus, ANTIVIRALS offers talented researchers a multidisciplinary and intersectoral training programme and prepares them for a future leading role in antiviral drug development in Europe.

Deliverables

List of deliverables.
ESR weblog	Websites, patent fillings, videos etc.	2020-02-27 15:43:43
PhD Thesis Titles & Degrees	Documents, reports	2020-02-27 15:43:43
International conference	Other	2020-02-27 15:43:43
Recruitment	Other	2019-10-29 16:55:23
ANTIVIRALS website	Websites, patent fillings, videos etc.	2019-10-29 16:55:24

Take a look to the deliverables list in detail: detailed list of ANTIVIRALS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	FranÃ§ois Ferron, Lorenzo Subissi, Ana Theresa Silveira De Morais, Nhung Thi Tuyet Le, Marion Sevajol, Laure Gluais, Etienne Decroly, Clemens Vonrhein, GÃ©rard Bricogne, Bruno Canard, Isabelle Imbert Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA published pages: E162-E171, ISSN: 0027-8424, DOI: 10.1073/pnas.1718806115	Proceedings of the National Academy of Sciences 115/2	2019-11-22
2017	Charlotte E. Melia, Hilde M. van der Schaar, Heyrhyoung Lyoo, Ronald W.A.L. Limpens, Qian Feng, Maryam Wahedi, Gijs J. Overheul, Ronald P. van Rij, Eric J. Snijder, Abraham J. Koster, Montserrat BÃ¡rcena, Frank J.M. van Kuppeveld Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles published pages: 587-599, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.09.068	Cell Reports 21/3	2019-11-22
2017	Heyrhyoung Lyoo, Cristina M. Dorobantu, Hilde M. van der Schaar, Frank J.M. van Kuppeveld Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase IIIÎ² or oxysterol binding protein published pages: 86-90, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.10.006	Antiviral Research 147	2019-11-22
2017	Jih Ru Hwu, Nitesh K. Gupta, Shwu-Chen Tsay, Wen-Chieh Huang, Irina C. Albulescu, Kristina Kovacikova, Martijn J. van Hemert Bis(benzofuranâ€“thiazolidinone)s and bis(benzofuranâ€“thiazinanone)s as inhibiting agents for chikungunya virus published pages: 96-101, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.08.008	Antiviral Research 146	2019-11-22
2016	Rachel Ulferts, S. Matthijn de Boer, Lonneke van der Linden, Lisa Bauer, Hey Rhyoung Lyoo, Maria J. MatÃ©, Julie LichiÃ¨re, Bruno Canard, Daphne Lelieveld, Wienand Omta, David Egan, Bruno Coutard, Frank J. M. van Kuppeveld Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C published pages: 2627-2638, ISSN: 0066-4804, DOI: 10.1128/AAC.02182-15	Antimicrobial Agents and Chemotherapy 60/5	2019-11-22
2017	Irina C. Albulescu, Kristina Kovacikova, Ali Tas, Eric J. Snijder, Martijn J. van Hemert Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles published pages: 230-236, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.04.016	Antiviral Research 143	2019-11-22
2017	Tassini S, Sun L, Lanko K, Crespan E, Langron E, Falchi F, Kissova M, Armijos-Rivera JI, Delang L, Mirabelli C, Neyts J, Pieroni M, Cavalli A, Costantino G, Maga G, Vergani P, Leyssen P, Radi M Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases. published pages: 1400-1416, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01521	J Med Chem 60(4)	2019-11-22
2017	Lisa Bauer, Heyrhyoung Lyoo, Hilde M van der Schaar, Jeroen RPM Strating, Frank JM van Kuppeveld Direct-acting antivirals and host-targeting strategies to combat enterovirus infections published pages: 1-8, ISSN: 1879-6257, DOI: 10.1016/j.coviro.2017.03.009	Current Opinion in Virology 24	2019-11-22
2017	Kristina Lanko, Kristel Eggermont, Abdulsamie Patel, Suzanne Kaptein, Leen Delang, Catherine M. Verfaillie, Johan Neyts Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals published pages: 82-86, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.07.010	Antiviral Research 145	2019-11-22
2016	Cristina M. Dorobantu, Lucian Albulescu, Heyrhyoung Lyoo, Mirjam van Kampen, Raffaele De Francesco, Volker Lohmann, Christian Harak, Hilde M. van der Schaar, Jeroen R. P. M. Strating, Alexander E. Gorbalenya, Frank J. M. van Kuppeveld Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIÎ± and Oxysterol-Binding Protein published pages: e00068-16, ISSN: 2379-5042, DOI: 10.1128/mSphere.00068-16	mSphere 1/3	2019-11-22
2017	Jeroen RPM Strating, Frank JM van Kuppeveld Viral rewiring of cellular lipid metabolism to create membranous replication compartments published pages: 24-33, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2017.02.005	Current Opinion in Cell Biology 47	2019-11-07
2019	Susan Schuster, Gijs J. Overheul, Lisa Bauer, Frank J. M. van Kuppeveld, Ronald P. van Rij No evidence for viral small RNA production and antiviral function of Argonaute 2 in human cells published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-50287-w	Scientific Reports 9/1	2019-11-07
2019	Vladimira Horova, Heyrhyoung Lyoo, Bartosz RÃ³Å¼ycki, Dominika Chalupska, Miroslav Smola, Jana Humpolickova, Jeroen R. P. M. Strating, Frank J. M. van Kuppeveld, Evzen Boura, Martin Klima Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites published pages: e1007962, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007962	PLOS Pathogens 15/8	2019-10-03
2019	Liang Sun, Hyunwook Lee, Hendrik Jan Thibaut, Kristina Lanko, Eva Rivero-Buceta, Carol Bator, Belen Martinez-Gualda, Kai Dallmeier, Leen Delang, Pieter Leyssen, Federico Gago, Ana San-FÃ©lix, Susan Hafenstein, Carmen Mirabelli, Johan Neyts Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid published pages: e1007760, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007760	PLOS Pathogens 15/5	2019-10-03
2019	Jim Baggen, Yue Liu, Heyrhyoung Lyoo, Arno L. W. van Vliet, Maryam Wahedi, Jost W. de Bruin, Richard W. Roberts, Pieter Overduin, Adam Meijer, Michael G. Rossmann, Hendrik Jan Thibaut, Frank J. M. van Kuppeveld Bypassing pan-enterovirus host factor PLA2G16 published pages: 3171, ISSN: 2041-1723, DOI: 10.1038/s41467-019-11256-z	Nature Communications 10/1	2019-10-03
2019	Natacha S. Ogando, Francois Ferron, Etienne Decroly, Bruno Canard, Clara C. Posthuma, Eric J. Snijder The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.01813	Frontiers in Microbiology 10	2019-10-03
2018	Mike Bray, Graciela Andrei, Ester Ballana, Kara Carter, David Durantel, Brian Gentry, Zlatko Janeba, Jennifer Moffat, Clasien J. Oomen, Bart Tarbet, Eva Riveira-MuÃ±oz, JosÃ©. A. EstÃ© Meeting report: 31st International Conference on Antiviral Research published pages: 88-102, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.08.002	Antiviral Research 158	2019-10-03
2019	Ana S. Ferreira-Ramos, Changqing Li, CÃ©cilia Eydoux, Jean Marie Contreras, Christophe Morice, Gilles QuÃ©rat, Alba Gigante, MarÃa-JesÃºs PÃ©rez PÃ©rez, Marie-Louise Jung, Bruno Canard, Jean-Claude Guillemot, Etienne Decroly, Bruno Coutard Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay published pages: 59-69, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2019.01.003	Antiviral Research 163	2019-10-03
2019	Lisa Bauer, Roberto Manganaro, Birgit Zonsics, Jeroen R. P. M. Strating, Priscila El Kazzi, Moira Lorenzo Lopez, Rachel Ulferts, Clara van Hoey, Maria J. MatÃ©, Thierry Langer, Bruno Coutard, Andrea Brancale, Frank J. M. van Kuppeveld Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner published pages: 1609-1623, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.9b00179	ACS Infectious Diseases 5/9	2019-10-03
2019	Ji-seong Yoon, Gyudong Kim, Dnyandev B. Jarhad, Hong-Rae Kim, Young-Sup Shin, Shuhao Qu, Pramod K. Sahu, Hea Ok Kim, Hyuk Woo Lee, Su Bin Wang, Yun Jeong Kong, Tong-Shin Chang, Natacha S. Ogando, Kristina Kovacikova, Eric J. Snijder, Clara C. Posthuma, Martijn J. van Hemert, Lak Shin Jeong Design, Synthesis, and Anti-RNA Virus Activity of 6â€²-Fluorinated-Aristeromycin Analogues published pages: 6346-6362, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00781	Journal of Medicinal Chemistry 62/13	2019-10-03
2018	Pietro Scaturro, Alexey Stukalov, Darya A. Haas, Mirko Cortese, Kalina Draganova, Anna PÅ‚aszczyca, Ralf Bartenschlager, Magdalena GÃ¶tz, Andreas Pichlmair An orthogonal proteomic survey uncovers novel Zika virus host factors published pages: 253-257, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0484-5	Nature 561/7722	2019-09-20
2019	Heyrhyoung Lyoo, Hilde M. van der Schaar, Cristina M. Dorobantu, Huib H. Rabouw, Jeroen R. P. M. Strating, Frank J. M. van Kuppeveld ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB published pages: , ISSN: 2150-7511, DOI: 10.1128/mBio.02742-18	mBio 10/1	2019-09-20
2019	Anna PÅ‚aszczyca, Pietro Scaturro, Christopher John Neufeldt, Mirko Cortese, Berati Cerikan, Salvatore Ferla, Andrea Brancale, Andreas Pichlmair, Ralf Bartenschlager A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle published pages: e1007736, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007736	PLOS Pathogens 15/5	2019-09-20
2018	C. E. Melia, H. M. van der Schaar, A. W. M. de Jong, H. R. Lyoo, E. J. Snijder, A. J. Koster, F. J. M. van Kuppeveld, M. BÃ¡rcena The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles published pages: e00420-18, ISSN: 2150-7511, DOI: 10.1128/mbio.00420-18	mBio 9/2	2019-08-06
2018	Lanko, Kristina; Ma, Yipeng; Delang, Leen; Mirabelli, Carmen; Neyts, Johan Antiviral effects of selected nucleoside analogs against human parechoviruses A1 and A3 published pages: , ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.12.009	Lirias 1	2019-08-06
2018	Angelica Corcuera, Katharina Stolle, Stefan Hillmer, Stefan Seitz, Ji-Young Lee, Ralf Bartenschlager, Alexander Birkmann, Andreas Urban Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro published pages: 135-142, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.07.011	Antiviral Research 158	2019-05-22
2018	Lisa Bauer, Salvatore Ferla, Sarah A. Head, Shridhar Bhat, Kalyan K. Pasunooti, Wei Q. Shi, Lucian Albulescu, Jun O. Liu, Andrea Brancale, Frank J.M. van Kuppeveld, Jeroen R.P.M. Strating Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP) published pages: 55-63, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.05.010	Antiviral Research 156	2019-05-22
2018	Maximilian MÃ¼nster, Anna PÅ‚aszczyca, Mirko Cortese, Christopher Neufeldt, Sarah Goellner, Gang Long, Ralf Bartenschlager A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy published pages: 368, ISSN: 1999-4915, DOI: 10.3390/v10070368	Viruses 10/7	2019-05-22

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The information about "ANTIVIRALS" are provided by the European Opendata Portal: CORDIS opendata.