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SCAMPICITY SIGNED

cAMP-dependend plasticity of striatal projection neurons in health and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SCAMPICITY project word cloud

Explore the words cloud of the SCAMPICITY project. It provides you a very rough idea of what is the project "SCAMPICITY" about.

protocols    spn    data    inhibits    dendritic    inform    secondly    look    structural    unknown    spiny    cell    sufficient    spines    drug    transient    symptoms    health    neurons    potentiated    disease    dspns    da    subgroups    notion    d2    aberrant    transmission    disorder    responsiveness    elevate    unravel    mediated    alone    groups    vivo    cascade    reveal    unraveling    activates    unpublished    spns    activation    pd    precise    potentially    receptor    opposite    model    optogenetic    weakening    express    parkinson    camp    animal    d1    signaling    dopamine    leads    messenger    motor    combat    presumably    caused    striatal    plasticity    coupled    interrupted    subsequent    altered    synaptic    projection    neurodegenerative    relates    suggest    synapse    death    resolution    treatments    induce    untested    corticostriatal    preferentially    striatum    strategies    ispns    lack    ask    spatiotemporal    tools    lastly    divide    levels   

Project "SCAMPICITY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF 

Organization address
address: Martinistrasse 52
city: HAMBURG
postcode: 20251
website: www.uke.uni-hamburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) coordinator 174˙806.00

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 Project objective

The project aims to reveal the so far unknown role of cAMP in structural and synaptic plasticity of striatal spiny projection neurons (SPNs) in health and disease. Striatal SPNs divide into two subgroups: the dSPNs and iSPNs. While dSPNs preferentially express the D1 dopamine (DA) receptor, iSPNs express the D2 receptor. Both are coupled to the cAMP second messenger cascade, however the D1-receptor activates and the D2-receptor inhibits it. DA has therefore opposite effects on the two SPN groups, both mediated by cAMP. Parkinson’s disease (PD) is the second most common neurodegenerative disorder. It is characterized by typical motor symptoms caused by the death of DA neurons and the subsequent lack of DA in the striatum. A long-standing but untested notion in the field is that loss of DA leads to aberrant cAMP levels and signaling in SPNs. The project will look at the role of cAMP in SPN synaptic and structural plasticity. We will use novel optogenetic tools that allow cell-type specific activation of cAMP, with high spatiotemporal resolution. Focusing on corticostriatal synaptic transmission, we want to ask if transient activation of cAMP alone is sufficient to induce plasticity (e.g. strengthening or weakening) of this synapse. Secondly, we will use known plasticity protocols and test if precise activation of cAMP can interrupted or potentiated them. Unpublished data suggest that in vivo drug treatments that presumably elevate cAMP in SPNs induce structural plasticity, i.e. loss of dendritic spines. Following this we will unravel if cell-type specific activation of cAMP is sufficient to induce structural changes and how this relates to synaptic plasticity. Lastly, we will test the long-standing notion that cAMP levels and the responsiveness of the cascade are altered in an animal model of PD. This project will advance our understanding of how SPNs work by unraveling cAMP’s role in plasticity, and potentially inform future strategies to combat PD.

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The information about "SCAMPICITY" are provided by the European Opendata Portal: CORDIS opendata.

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