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READCELL SIGNED

System for the efficient and non-invasive harvesting and RElease of ADherent CELLs controlled by light

Total Cost €

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EC-Contrib. €

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Partnership

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 READCELL project word cloud

Explore the words cloud of the READCELL project. It provides you a very rough idea of what is the project "READCELL" about.

shape    gold    release    preliminary    nanostructured    poses    point    locations    nanoparticles    attached    turn    found    certain    external    basis    market    performed    types    contained    least    environment    manual    automated    immobilized    biopharmaceutical    million    source    enzymatic    adhesion    energy    driving    submitted    ing    recovery    coming    modifications    patterns    immobilising    harsh    localised    manually    geometrical    invasive    successful    idea    biopharmaceuticals    electromagnetic    suspension    mainly    surface    therapy    share    adherent    interaction    annual    device    imbalance    harvest    enzymes    size    damaging    biochemical    rate    proof    patent    disrupting    cells    cell    cultured    interacts    contaminating    hydrolyzing    automation    volumetric    introducing    150    hyperthermal    treatment    nature    culture    valued    lags    introduce    risk    productivity    radiation    attack    experiments    efficient    euros    exposure   

Project "READCELL" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙940 €
 EC max contribution 149˙940 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2017-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 149˙940.00

Map

 Project objective

The Biopharmaceuticals market is currently valued at about 150,000 million euros with an annual growth rate of 6 %. Biopharmaceutical products are mainly obtained from cells cultured in contained systems. Adherent cells represent an important share of the cell types used in production processes and are the major source of cell therapy products. Productivity of current processes for adherent cells culture lags behind those based on suspension cells and the reasons for this imbalance are to be found mainly on the low volumetric productivity and automation of current processes for adherent cells culture. Recovery of cells from the surface they are attached to, the so-called cell harvest is commonly performed by disrupting the interaction of the cells with the support by manually introducing hydrolyzing enzymes into the culture device. These enzymes attack the cell at the adhesion point driving them into suspension for further recovery. Due to the manual nature of the cell harvest step, the exposure of cells to the external environment during the enzymatic treatment and the harsh biochemical conditions, this is one of the least efficient steps in the production process and poses an important risk of damaging and contaminating the culture. The idea proposed in this project for Proof of Concept will turn the cell harvest step into an automated, non-invasive and efficient step in the cell culture process. To achieve this goal we will introduce nanostructured modifications in the cell culture support by immobilising gold nanoparticles of defined size and shape, in certain geometrical patterns. The resulting cell culture support interacts with low energy electromagnetic radiation coming from an external and non-invasive source, creating localised hyperthermal effects at the locations of the immobilized nanoparticles and leading to the release of growing cells. Results of successful preliminary experiments are the basis of a recently submitted patent application.

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The information about "READCELL" are provided by the European Opendata Portal: CORDIS opendata.

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