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AGORAs TERMINATED

AGeing effects on human aORta: from shApe to flowS

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AGORAs project word cloud

Explore the words cloud of the AGORAs project. It provides you a very rough idea of what is the project "AGORAs" about.

canada    aneurysm    hemodynamic    fluid    diagnosis    ageing    cardiovascular    velocity    months    aorta    36    numeric    assumptions    stress    aortas    descriptors    italy    pcmri    alterations    dynamics    dependent    cfd    underlie    quantitative    overcome    acquired    resolution    resonance    data    diseases    diagnostic    subject    morphometric    clinical    monitoring    subjects    tools    districts    remodeling    solver    simplify    limitations    carotid    risk    encumbered    return    aortic    accuracy    4d    spatial    quantifiable    di    characterization    consuming    toolkit    time    training    wall    contrast    utility    computational    imaging    vivo    toronto    university    morphological    synergistic    purposes    incorporated    cvds    flow    simulations    assimilation    torino    morphology    global    accelerated    sectional    temporal    prognostic    age    dataset    missing    vascular    technique    culprits    interplay    magnetic    fellowship    shear    quantification    complemented    validating    hemodynamics    mainly    suggesting    operator    source    cross    streamline    successful    politecnico   

Project "AGORAs" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI TORINO 

Organization address
address: CORSO DUCA DEGLI ABRUZZI 24
city: TORINO
postcode: 10129
website: www.polito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 229˙761 €
 EC max contribution 229˙761 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-05-16   to  2019-05-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 229˙761.00

Map

 Project objective

Age-related remodeling of the aorta is associated with alterations in morphology and hemodynamics . These alterations are involved and accelerated in the presence of cardiovascular diseases (CVDs), suggesting that they are the likely culprits that underlie the increased cardiovascular risk associated with ageing . However, an advanced characterization of the age-related morphological/hemodynamic alterations and on their synergistic interplay is missing, mainly because encumbered by time-consuming operator-dependent tasks. In this 36 months global fellowship (University of Toronto, Canada and Politecnico di Torino, Italy), the potential clinical utility of such a characterization will be addressed, developing tools for the quantitative assessment of the age-associated alterations in a large-scale cross-sectional dataset of aortas from subjects with successful ageing. After training on phase-contrast magnetic resonance imaging (PCMRI) technique, for each subject the 4D velocity field will be acquired. Quantitative morphometric parameters will be defined and evaluated in vivo. To investigate aortic hemodynamics, PCMRI will be complemented by computational fluid dynamics (CFD) to overcome PCMRI limitations on temporal/spatial resolution and wall shear stress quantification . The impact of CFD assumptions will be assessed by validating CFD results with PCMRI measurements. To improve CFD results accuracy, in the return phase PCMRI data will be incorporated into the numeric simulations, through the assimilation of the acquired flow fields into the CFD solver. Descriptors quantifiable in vivo and able to simplify the understanding of the complex 4D hemodynamic and of age-associated remodeling will be defined. The new tools for diagnostic/prognostic purposes will be integrated within the open-source Vascular Modelling ToolKit, to facilitate and streamline the diagnosis and monitoring of a wider range of CVDs when applied to other vascular districts (e.g. carotid, aneurysm).

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The information about "AGORAS" are provided by the European Opendata Portal: CORDIS opendata.

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