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AGORAs TERMINATED

AGeing effects on human aORta: from shApe to flowS

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AGORAs project word cloud

Explore the words cloud of the AGORAs project. It provides you a very rough idea of what is the project "AGORAs" about.

diagnostic    university    incorporated    numeric    districts    characterization    limitations    morphometric    vascular    spatial    cfd    canada    torino    utility    resonance    aneurysm    alterations    acquired    complemented    simplify    descriptors    vivo    subjects    purposes    subject    carotid    remodeling    diagnosis    technique    risk    aortic    temporal    global    encumbered    toronto    velocity    culprits    hemodynamics    computational    wall    politecnico    pcmri    interplay    cvds    cross    quantifiable    sectional    accuracy    streamline    mainly    solver    di    simulations    prognostic    ageing    successful    clinical    aorta    age    tools    hemodynamic    fluid    quantification    training    missing    dynamics    italy    dependent    consuming    shear    assimilation    resolution    assumptions    flow    synergistic    source    fellowship    dataset    aortas    data    validating    operator    accelerated    morphological    imaging    suggesting    magnetic    underlie    return    4d    overcome    toolkit    morphology    quantitative    cardiovascular    time    months    monitoring    diseases    36    contrast    stress   

Project "AGORAs" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI TORINO 

Organization address
address: CORSO DUCA DEGLI ABRUZZI 24
city: TORINO
postcode: 10129
website: www.polito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 229˙761 €
 EC max contribution 229˙761 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-05-16   to  2019-05-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 229˙761.00

Map

 Project objective

Age-related remodeling of the aorta is associated with alterations in morphology and hemodynamics . These alterations are involved and accelerated in the presence of cardiovascular diseases (CVDs), suggesting that they are the likely culprits that underlie the increased cardiovascular risk associated with ageing . However, an advanced characterization of the age-related morphological/hemodynamic alterations and on their synergistic interplay is missing, mainly because encumbered by time-consuming operator-dependent tasks. In this 36 months global fellowship (University of Toronto, Canada and Politecnico di Torino, Italy), the potential clinical utility of such a characterization will be addressed, developing tools for the quantitative assessment of the age-associated alterations in a large-scale cross-sectional dataset of aortas from subjects with successful ageing. After training on phase-contrast magnetic resonance imaging (PCMRI) technique, for each subject the 4D velocity field will be acquired. Quantitative morphometric parameters will be defined and evaluated in vivo. To investigate aortic hemodynamics, PCMRI will be complemented by computational fluid dynamics (CFD) to overcome PCMRI limitations on temporal/spatial resolution and wall shear stress quantification . The impact of CFD assumptions will be assessed by validating CFD results with PCMRI measurements. To improve CFD results accuracy, in the return phase PCMRI data will be incorporated into the numeric simulations, through the assimilation of the acquired flow fields into the CFD solver. Descriptors quantifiable in vivo and able to simplify the understanding of the complex 4D hemodynamic and of age-associated remodeling will be defined. The new tools for diagnostic/prognostic purposes will be integrated within the open-source Vascular Modelling ToolKit, to facilitate and streamline the diagnosis and monitoring of a wider range of CVDs when applied to other vascular districts (e.g. carotid, aneurysm).

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The information about "AGORAS" are provided by the European Opendata Portal: CORDIS opendata.

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