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Yeast-Glyco

Nucleocytoplasmic O-glycosylation in Yeast

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Yeast-Glyco project word cloud

Explore the words cloud of the Yeast-Glyco project. It provides you a very rough idea of what is the project "Yeast-Glyco" about.

orchestrate signaling glcnacylation sugar utilize modifications mannose industry transduction discovery molecules mitochondrial entirely area demonstrating mechanism eukaryotic manipulation vital signal cellular lacks translational promise manipulate bioprocessing cycling bioproduction explore difficult nucleocytoplasmic understand protein maintains operates compartments attachment man functional cytoplasmic survive post unknown linked localization proteins cell demonstrates nuclear improvements myriad mechanisms phosphorylation dynamic found modification glycosylation ptms crosstalk hitherto enzymes regulation yeast platforms core possess mirrors biotechnology eukaryotes baker extensive removal functions responsible exhibit holds

Project "Yeast-Glyco" data sheet

The following table provides information about the project.

Coordinator	KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	https://icmm.ku.dk/english/research-groups/halim-group/
Total cost	278˙227 €
EC max contribution	278˙227 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-GF
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	278˙227.00
2	THE ROCKEFELLER UNIVERSITY NOT FOR PROFIT CORPORATION THE ROCKEFELLER UNIVERSITY NOT FOR PROFIT CORPORATION Organization address address: YORK AVENUE 1230 city: NEW YORK postcode: 10065 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	partner	0.00

Map

Project objective

Signal transduction via post-translational modifications (PTMs) of proteins maintains essential cellular processes in all eukaryotes. Similar to protein phosphorylation, O-GlcNAcylation is a vital signaling mechanism that involves the dynamic cycling of sugar molecules on proteins and these PTMs exhibit extensive crosstalk for regulation of core cellular processes. The only eukaryotic cell type that lacks both signaling mechanisms is yeast and it has been difficult to understand how yeast survive without the essential functions of O-GlcNAcylation. This proposal is based on our discovery demonstrating that baker’s yeast has an O-linked mannose (O-Man) glycosylation system that operates in nuclear, cytoplasmic and mitochondrial compartments. The localization of these O-Man modifications on yeast proteins mirrors that of O-GlcNAcylation found in higher eukaryotes and this discovery demonstrates that yeast possess a hitherto unknown signaling mechanism involved a myriad of cellular processes. This research project aims to explore when and where yeast utilize the nucleocytoplasmic O-Man signaling system and to understand the functional consequences of this novel modification. In addition, the project aims to identify and characterize the enzymes responsible for the attachment and removal of nucleocytoplasmic O-Man modifications in order to enable manipulation of the system for improvements in yeast-based bioproduction and bioprocessing platforms. The project will open an entirely new area of research by bringing novel knowledge on how yeast orchestrate cellular signaling and advance our understanding on how essential cellular processes are controlled in eukaryotes. This holds promise to bring unique opportunities to manipulate yeast for improvements and open for wide applications in industry and biotechnology.

Publications

List of publications.
year	authors and title	journal	last update
2019	Ida Signe Bohse Larsen, Yoshiki Narimatsu, Henrik Clausen, Hiren J Joshi, Adnan Halim Multiple distinct O-Mannosylation pathways in eukaryotes published pages: 171-178, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2019.03.003	Current Opinion in Structural Biology 56	2020-03-20
2017	Ida Signe Bohse Larsen, Yoshiki Narimatsu, Hiren Jitendra Joshi, Zhang Yang, Oliver J. Harrison, Julia Brasch, Lawrence Shapiro, Barry Honig, Sergey Y. Vakhrushev, Henrik Clausen, Adnan Halim Mammalian O -mannosylation of cadherins and plexins is independent of protein O -mannosyltransferases 1 and 2 published pages: 11586-11598, ISSN: 0021-9258, DOI: 10.1074/jbc.M117.794487	Journal of Biological Chemistry 292/27	2020-03-20
2017	Adnan Halim, Jan Haug Anonsen Microbial glycoproteomics published pages: 143-150, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2017.03.005	Current Opinion in Structural Biology 44	2020-03-20
2017	Ida Signe Bohse Larsen, Yoshiki Narimatsu, Hiren Jitendra Joshi, Lina Siukstaite, Oliver J. Harrison, Julia Brasch, Kerry M. Goodman, Lars Hansen, Lawrence Shapiro, Barry Honig, Sergey Y. Vakhrushev, Henrik Clausen, Adnan Halim Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins published pages: 11163-11168, ISSN: 0027-8424, DOI: 10.1073/pnas.1708319114	Proceedings of the National Academy of Sciences 114/42	2020-03-20

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