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PIGYVAX SIGNED

Making a yeast-based candidate vaccine against Porcine Epidemic Diarrhea Virus (PEDV)

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PIGYVAX project word cloud

Explore the words cloud of the PIGYVAX project. It provides you a very rough idea of what is the project "PIGYVAX" about.

vaccine gaining yeast practical protein immunogenicity pigyvax convenient vaccines candidates sows researcher transferred presenting orally antigen accessory spike frantz succumbing adjuvant biotec cells create certified expertise causing microorganism immune return fruits initiate protect thailand pedv pathogen farms recognition industry utilize pasteur ribonucleoprotein globally disease rendering protective piglets pig rnp s1 auto measles safe pathogenesis pastoris monomeric passively express multimerization swine fused nanoparticles animal stimulate host reduces complementation feeds platform phanramphoei successful institut dr

Project "PIGYVAX" data sheet

The following table provides information about the project.

Coordinator	INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.pigsdontcry.com and https
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-06-13 to 2018-06-12

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	coordinator	185˙076.00

Map

Project objective

PIGYVAX aims to create pig vaccine candidates against PEDV, a pathogen of swine causing significant challenges to the swine industry globally. This project will utilize yeast-based vaccine carrying nanoparticles of measles ribonucleoprotein (RNP) fused with PEDV spike protein (S1). The multimerization of monomeric S1 antigen through RNP will increase immunogenicity due to better recognition of antigen presenting cells. As the yeast delivery system has strong auto-adjuvant properties, the vaccine does not require complementation with accessory adjuvant, which reduces the cost of vaccine production. Moreover, P. pastoris yeast, commonly present on fruits, is a certified safe microorganism for animal feeds rendering it a most practical and convenient way to deliver vaccines to large-scale farms. Therefore, we aim to use this vaccine platform to express S1 antigen of PEDV and deliver it orally to stimulate a protective immune response against PEDV in sows, which will be passively transferred to fully protect piglets from succumbing to the disease. In this project, Dr. Phanramphoei Frantz will utilize her knowledge on pathogenesis of PEDV and the yeast-RNP platform while gaining expertise on vaccine study and development from the host institute. This will initiate a successful collaboration project between Institut Pasteur and BIOTEC (Thailand) to where the experienced researcher will return after the project.

Publications

List of publications.
year	authors and title	journal	last update
2018	Phanramphoei N. Frantz, Samaporn Teeravechyan, FrÃ©dÃ©ric Tangy Measles-derived vaccines to prevent emerging viral diseases published pages: , ISSN: 1286-4579, DOI: 10.1016/j.micinf.2018.01.005	Microbes and Infection	2019-06-13

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The information about "PIGYVAX" are provided by the European Opendata Portal: CORDIS opendata.