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Train2Target SIGNED

An integrated mulTidisciplinary appRoach towards a new generAtIon of aNtibiotics: Targeting function and cross-talk of bacterial Envelope proTein machineries

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

Train2Target project word cloud

Explore the words cloud of the Train2Target project. It provides you a very rough idea of what is the project "Train2Target" about.

chemical biophysics quality genetic biogenesis compounds complementary spread entire specialised hit infections train2target antimicrobials negative market whereas synthesis alternative cell altering combination pathogens sources envelope biochemical alarming druggable bacteria drug gram inhibit classes assays industry transferable valuable 2target covers job infective scientific clinicians leads multidisciplinary pharma identification strategies expertise biophysical platform ensured innovative structural smes anti microbiology imaging partnership credibility 15 variety function biotech perspective academic train leaders training skills urgently biochemistry generation interdisciplinary industrial network drugs scaffolds renowned assembly threats resistant optimized stage bacterial equip options machines limited discovery academia combat screened competitive ranging groups leaving excellence biology assemble misbalancing genetics antibacterial

Project "Train2Target" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	https://www.train2target.eu/
Total cost	3˙931˙378 €
EC max contribution	3˙931˙378 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI MILANO UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	516˙122.00
2	UNIVERSITY OF NEWCASTLE UPON TYNE UNIVERSITY OF NEWCASTLE UPON TYNE Organization address address: KINGS GATE city: NEWCASTLE UPON TYNE postcode: NE1 7RU website: http://www.ncl.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWCASTLE UPON TYNE)	participant	546˙575.00
3	UNIVERSITEIT VAN AMSTERDAM UNIVERSITEIT VAN AMSTERDAM Organization address address: SPUI 21 city: AMSTERDAM postcode: 1012WX website: www.uva.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	510˙748.00
4	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	participant	501˙120.00
5	UNION THERAPEUTICS AS UNION THERAPEUTICS AS Organization address address: TUBORG HAVNEVEJ 18 city: HELLERUP postcode: 2900 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HELLERUP)	participant	290˙081.00
6	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	273˙287.00
7	BIOVERSYS AG BIOVERSYS AG Organization address address: HOCHBERGERSTRASSE 60 C TECHNOLOGIEPARK BASEL city: BASEL postcode: 4057 website: www.bioversys.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	265˙226.00
8	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	262˙875.00
9	NAICONS SRL NAICONS SRL Organization address address: VIA GUARAGNA 3 city: SARONNO VA postcode: 20147 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SARONNO VA)	participant	258˙061.00
10	UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Organization address address: CORSO UMBERTO I, 40 city: NAPOLI postcode: 80138 website: www.unina.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (NAPOLI)	participant	258˙061.00
11	AICURIS ANTI-INFECTIVE CURES GMBH AICURIS ANTI-INFECTIVE CURES GMBH Organization address address: FRIEDRICH EBERT STRASSE 475 city: WUPPERTAL postcode: 42117 website: www.aicuris.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WUPPERTAL)	participant	249˙216.00
12	ACCELOPMENT AG ACCELOPMENT AG Organization address address: SEEFELDSTRASSE 198 city: ZUERICH postcode: 8008 website: www.accelopment.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	partner	0.00
13	Antabio SAS Antabio SAS Organization address address: Rue Pierre et Marie Curie 436 city: LABEGE postcode: 31670 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LABEGE)	partner	0.00
14	Basilea Pharmaceutica Ltd Basilea Pharmaceutica Ltd Organization address address: GRENZACHERSTRASSE 487 city: BASEL postcode: 4058 website: www.basilea.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	partner	0.00
15	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	partner	0.00
16	UNIVERSITAT BASEL UNIVERSITAT BASEL Organization address address: PETERSPLATZ 1 city: BASEL postcode: 4051 website: www.unibas.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	partner	0.00
17	ZOETIS INTERNATIONAL SERVICES SAS ZOETIS INTERNATIONAL SERVICES SAS Organization address address: AVENUE DU DOCTEUR LANNELONGUE 23-25 city: PARIS postcode: 75014 website: www.zoetis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	partner	0.00

Map

Project objective

Train2Target is a multidisciplinary European Training Network built to address the challenge of the discovery of alternative antimicrobials. Innovative strategies to deliver a next generation of drugs are urgently needed. The alarming threats and spread of multi-drug resistant bacteria is currently leaving clinicians with very limited options to combat infections especially those from Gram-negative pathogens.

The Train 2Target research programme focuses on the assembly of the well-known bacterial cell envelope from a new perspective. Indeed it aims to inhibit novel targets in envelope biogenesis by altering the function and misbalancing the coordination of envelope assembly machines, which build and assemble the Gram-negative bacterial envelope. A wide variety of chemical classes and compounds sources will be screened using innovative biochemical, biophysical and genetic assays to identify valuable hit scaffolds to be optimized into druggable leads.

The high quality and credibility of our consortium is ensured by a strong interdisciplinary academia-industry partnership to encompass different complementary expertise ranging from microbiology, bacterial genetics, biochemistry, cell imaging, structural biology, biophysics and chemical synthesis. Our 9 academic groups are all renowned leaders in the cell envelope biogenesis field, whereas the complementary 5 SMEs and 3 Industry partners are specialised in drug discovery and development of novel anti-infective drugs. This unique combination of scientific excellence and industrial know-how in drug discovery covers the entire process from the design to the implementation of innovative antibacterial strategies and lead identification.

Train2Target also represents a unique research platform to train 15 Early Stage Researchers and equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the pharma/biotech job market.

Deliverables

List of deliverables.
SB and SAB established	Other	2020-01-24 15:00:40
Website	Websites, patent fillings, videos etc.	2020-01-24 15:00:40
Industry course	Other	2020-01-24 15:00:40

Take a look to the deliverables list in detail: detailed list of Train2Target deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Paola Sperandeo, Alessandra M. Martorana, Alessandra Polissi The lipopolysaccharide transport (Lpt) machinery: A nonconventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria published pages: 17981-17990, ISSN: 0021-9258, DOI: 10.1074/jbc.R117.802512	Journal of Biological Chemistry 292/44	2020-01-24
2018	Cedric Laguri, Alba Silipo, Alessandra M. Martorana, Paul Schanda, Roberta Marchetti, Alessandra Polissi, Antonio Molinaro, Jean-Pierre Simorre Solid State NMR Studies of Intact Lipopolysaccharide Endotoxin published pages: 2106-2113, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00271	ACS Chemical Biology 13/8	2020-01-24
2018	Katharina Peters, Manuel Pazos, Zainab Edoo, Jean-Emmanuel Hugonnet, Alessandra M. Martorana, Alessandra Polissi, Michael S. VanNieuwenhze, Michel Arthur, Waldemar Vollmer Copper inhibits peptidoglycan LD-transpeptidases suppressing Î²-lactam resistance due to bypass of penicillin-binding proteins published pages: 10786-10791, ISSN: 0027-8424, DOI: 10.1073/pnas.1809285115	Proceedings of the National Academy of Sciences 115/42	2020-01-24
2019	Nils Y. Meiresonne, Elisa Consoli, Laureen M. Y. Mertens, Anna Chertkova, Joachim Goedhart, Tanneke den Blaauwen Superfolder mTurquoise2 ox optimized for the bacterial periplasm allows high efficiency in vivo FRET of cell division antibiotic targets published pages: , ISSN: 0950-382X, DOI: 10.1111/mmi.14206	Molecular Microbiology	2020-01-24
2019	NiccolÃ² MorÃ¨, Alessandra M. Martorana, Jacob Biboy, Christian Otten, Matthias Winkle, Carlos K. Gurnani Serrano, Alejandro MontÃ³n Silva, Lisa Atkinson, Hamish Yau, Eefjan Breukink, Tanneke den Blaauwen, Waldemar Vollmer, Alessandra Polissi Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.02729-18	mBio 10/1	2020-01-24
2017	Cedric Laguri, Paola Sperandeo, Kevin Pounot, Isabel Ayala, Alba Silipo, Catherine M. Bougault, Antonio Molinaro, Alessandra Polissi, Jean-Pierre Simorre Interaction of lipopolysaccharides at intermolecular sites of the periplasmic Lpt transport assembly published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-10136-0	Scientific Reports 7/1	2020-01-24

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The information about "TRAIN2TARGET" are provided by the European Opendata Portal: CORDIS opendata.

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