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iGOLDD

Commercialising MR-HIFU: an Image-Guided Local Drug-Delivery Platform

Total Cost €

EC-Contrib. €

Partnership

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iGOLDD project word cloud

Explore the words cloud of the iGOLDD project. It provides you a very rough idea of what is the project "iGOLDD" about.

shelved health tumour deep opportunity proof body pharmaceutical rates erc ip attrition routes powerful hifu promise human locally biotechnology technological alternative paradigm inside mr continuous boost continues invasive prepare regarding rate tissue commercialisation cancer gain companies antibody 2 exact offers team reuse clinical dollar imaging heating billion reducing model drugs surrounding magnetic precision guided moonen pharma image trials efficacy temperature industry solution 95 business alone completely market strategy mri prof platform indications definition commercialise technique precisely motion conjugates optimise correction macromolecular introduction positioning sound therapies position drug stand igoldd commercial resonance ultrasound

Project "iGOLDD" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-PoC
Funding Scheme	ERC-POC
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2018-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	150˙000.00

Map

Project objective

Reducing the high attrition rates in drug development continues to be a key challenge for the pharmaceutical industry. With average drug development costs of over $2 billion dollar and a 95% failure rate of cancer drugs in Phase I trials, a new paradigm is highly needed. iGOLDD represents a unique opportunity for the commercialisation of a powerful alternative drug-delivery solution that has the potential to locally boost the efficacy of many drugs for a range of clinical indications. Prof. Moonen and his team, as part of the ERC project Sound Pharma, have developed a powerful technology platform, based on magnetic resonance guided focused ultrasound (MR-HIFU), that can be used for high-precision image-guided drug delivery, HIFU is the only known technique capable of completely non-invasive, precisely controlled heating deep inside the human body. MRI allows continuous imaging of the tumour and surrounding health tissue for target definition. iGOLDD aims to commercialise this unique technology as a stand-alone drug delivery platform that can be widely offered to pharmaceutical and biotechnology companies to improve new or existing drugs or reuse shelved therapies. In iGOLDD we will further optimise the HIFU technology (in particular temperature control and motion correction) for drug delivery of macromolecular drugs, such as antibody-drug conjugates, to demonstrate the large potential of our drug delivery platform. In addition, we will prepare for market introduction, by defining the exact business strategy, model and positioning for commercial success. We will develop the business strategy that offers the most promise, based on the technological aspects of the project, the market needs and trends, the end-user needs and the IP-position. During this project, we will gain technical and commercial proof-of-concept, which will provide us with the necessary information regarding potential commercialisation routes.

Publications

List of publications.
year	authors and title	journal	last update
2017	Cornel Zachiu, Baudouin Denis de Senneville, Ivan D. Dmitriev, Chrit T. W. Moonen, Mario Ries A framework for continuous target tracking during MR-guided high intensity focused ultrasound thermal ablations in the abdomen published pages: 1-18, ISSN: 2050-5736, DOI: 10.1186/s40349-017-0106-y	Journal of Therapeutic Ultrasound 5/1	2019-06-13

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The information about "IGOLDD" are provided by the European Opendata Portal: CORDIS opendata.